scholarly journals Aggregate organ failure rates among dengue patients in Malaysia: Five years' risk analysis (2010–2015)

2017 ◽  
Vol 7 (12) ◽  
pp. 806-808
Author(s):  
Tahir Mehmood Khan ◽  
◽  
Yee Chang Soh ◽  
Siang Fei Yeoh ◽  
Learn-Han Lee ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Organ Failure ◽  
Failure Rates

scholarly journals Risk Analysis for Initial Needs (RAIN): Improving a Time Zero Startup Plan through Resource Based Auditing (RBA) and a Launch Focused Strategy

10.28945/3844 ◽  
2017 ◽  
Vol 1 ◽  
pp. 081-095
Author(s):  
Gilbert Gonzalez
Keyword(s):  
Economic Growth ◽  
Risk Analysis ◽  
Business Plan ◽  
Time Frame ◽  
Business Failure ◽  
Planning Model ◽  
Failure Rates ◽  
Government Programs ◽  
Time Zero ◽  
The Creation

Using the Risk Analysis for Initial Needs (RAIN) planning model and its resource-based audit (RBA) tool to support the creation of a time zero startup business plan will improve the perceived value of the startup plan to founders and stakeholders by identifying gaps between the needs and availability of the needed resources at time zero. The case has been made that successful startups are beneficial to all stakeholders in the community, while startups that fail to sustain create significant costs, both actual and opportunity, for both themselves and the community. Depending on the source and the time frame referenced, emerging business failure rates range from 50% to 80% (BLS, 2016). This figure demonstrates the disappointing inefficiency of startups. What is not clear is whether the high failure rate, which has come to be accepted, is necessary. The creation of RAIN was motivated by the desire to seek a solution to the business problem of continuously high failure rates through improved startup business planning. RAIN improves the startup business plan by replacing traditional environmental auditing with resource-based auditing (RBA), and focusing on sustainability and scalability during the post-launch Incubation period. Using the RAIN startup planning model at time zero and throughout the early stages of the business lifecycle should improve sustainability and encourage founders to embrace developing and using startup plans. Experts agree that entrepreneurial enterprises are creators of economic growth. In fact, a recent study by Guzman and Stern looked at the attributable growth for a community based on the quality of the startups (Guzman & Stern, 2016). It was found that “a doubling of the entrepreneurial quality predicts an increase of 6.8% in GDP in 11 years” (Frick, 2016). This study emphasizes the need for more successes, rather than more startups. “We’ve long known that new businesses matter to the economy and that it’s a small group of fast-growing firms that matter most, because of the jobs and innovation they bring” (Frick, 2016). Founders, investors, creditors, incubators, government programs, and entrepreneurial education programs all benefit from improving the sustainability rate of startups. These benefits include job creation, debt default minimization, and expanded economic growth through the multiplier effect of the surviving business entity (Guzman & Stern, 2016). Improving the success rate of new businesses through improved time zero planning will have positive consequences for the community and economy.

Risk analysis of sternal wound infection after coronary bypass grafting

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
J Schönebeck ◽  
B Reiter ◽  
O Haye ◽  
D Böhm ◽  
M Ismail ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Wound Infection ◽  
Coronary Bypass ◽  
Bypass Grafting ◽  
Sternal Wound Infection ◽  
Coronary Bypass Grafting

Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis

1994 ◽  
Vol 71 (06) ◽  
pp. 768-772 ◽  
Author(s):  
Gerhard Dickneite ◽  
Jörg Czech
Keyword(s):  
Septic Shock ◽  
Klebsiella Pneumoniae ◽  
Organ Failure ◽  
Therapeutic Effect ◽  
Disseminated Intravascular Coagulation ◽  
Post Infection ◽  
Thrombin Inhibitor ◽  
Bolus Administration ◽  
Bacterial Burden ◽  
Recombinant Hirudin

SummaryRats which were infected with the gramnegative pathogen Klebsiella pneumoniae develop disseminated intravascular coagulation (DIC), multi-organ failure (MOF) and finally die in a septic shock. We investigated the therapeutic effect of antibiotic (tobramycin) treatment combined with the infusion of the highly specific thrombin inhibitor rec. hirudin. Although administration of 2 mg/kg tobramycin alone leads to a decrease of the bacterial burden, DIC could not be prevented. Infusion of rec. hirudin (0.25 mg/kg x h) for 4 h (start of treatment 1 h post infection), in addition to a bolus administration of tobramycin, led to an amelioration of DIC parameters as fibrinogen, thrombin-antithrombin complex (TAT) and platelets. Serum transaminase levels (GOT, GPT) as a marker of MOF were significantly improved by rec. hirudin, the T50 value increased from 17 h in the tobramycin group to 42 h in the tobramycin + rec. hirudin giuup, muilality rates were 90% or 60%, respectively. Combination of heparin (10011/kg x h) and tobramycin was not effective on survival.

Sign in / Sign up

Export Citation Format

Share Document