Comparative Study between Extent of Necrosis and Organ Failure Rates in Acute Pancreatitis

Mo1322 Impact of Naso-Jejunal Fluid Resuscitation in Predicted Severe Acute Pancreatitis on Necrosis, Organ Failure and Intra-Abdominal Pressure; a Randomised Comparative Study With Intravenous Ringer's Lactate

Gastroenterology ◽

10.1016/s0016-5085(14)62237-x ◽

2014 ◽

Vol 146 (5) ◽

pp. S-619

Author(s):

Vishal Sharma ◽

Ravi Sharma ◽

Surinder S. Rana ◽

Vinita Chaudhary ◽

Rajesh Gupta ◽

...

Keyword(s):

Acute Pancreatitis ◽

Comparative Study ◽

Organ Failure ◽

Severe Acute Pancreatitis ◽

Fluid Resuscitation ◽

Abdominal Pressure ◽

Ringer’S Lactate

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The role of soluble urokinase plasminogen activator receptor as an early biomarker of severity and organ failure in patients with acute pancreatitis

10.26226/morressier.57c5383fd462b80296c9bd2a ◽

2016 ◽

Author(s):

Amir Soleimani

Keyword(s):

Acute Pancreatitis ◽

Organ Failure ◽

Plasminogen Activator ◽

Urokinase Plasminogen Activator ◽

Urokinase Plasminogen Activator Receptor ◽

Early Biomarker ◽

Plasminogen Activator Receptor

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Early on‐demand drainage or standard management for acute pancreatitis patients with acute necrotic collections and persistent organ failure: a pilot randomized controlled trial

Journal of Hepato-Biliary-Pancreatic Sciences ◽

10.1002/jhbp.915 ◽

2021 ◽

Author(s):

Lu Ke ◽

Xiaowu Dong ◽

Tao Chen ◽

Gordon S. Doig ◽

Gang Li ◽

...

Keyword(s):

Acute Pancreatitis ◽

Randomized Controlled Trial ◽

Organ Failure ◽

Controlled Trial ◽

On Demand ◽

Randomized Controlled ◽

Persistent Organ Failure ◽

Standard Management ◽

Pilot Randomized Controlled Trial

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Accuracy of angiopoietin-2 for predicting organ failure in patients with acute pancreatitis: a systematic review and meta-analysis

Journal of International Medical Research ◽

10.1177/0300060520986708 ◽

2021 ◽

Vol 49 (2) ◽

pp. 030006052098670

Author(s):

Yongcai Lv ◽

Yanhua Yao ◽

Qi Liu ◽

Jingjing Lei

Keyword(s):

Acute Pancreatitis ◽

Organ Failure ◽

Meta Analysis ◽

Characteristic Curve ◽

Diagnostic Odds Ratio ◽

Cochrane Library ◽

Case Control Studies ◽

Likelihood Ratios ◽

Summary Receiver Operating Characteristic ◽

Angiopoietin 2

Objective Our aim was to assess the accuracy of angiopoietin-2 (Ang-2) as a prognostic marker for acute pancreatitis (AP) with organ failure (OF). Methods We undertook a systematic search of the PubMed, Cochrane Library, Embase, Chinese Journals Full-text, Wanfang, China Biology Medicine disc, and Weipu databases to identify eligible cohort studies on the predictive value of Ang-2 for AP with OF. The main outcome measures were sensitivity and specificity. The effects were pooled using a bivariate mixed-effects model. Results Six articles with seven case-control studies (n = 650) were included. Pooled sensitivity, specificity, and positive and negative likelihood ratios with 95% confidence intervals (CI) for AP with OF were 0.93 (95%CI: 0.75–0.99), 0.85 (95%CI: 0.75–0.92), 6.40 (95%CI: 3.36–12.19), and 0.08 (95%CI: 0.02–0.36), respectively. The area under the summary receiver operating characteristic curve was 0.95 (95%CI: 0.92–0.96), and the diagnostic odds ratio was 83.18 (95%CI: 11.50–623.17). Subgroup analysis showed that admission time of AP onset (< or ≥24 hours) was a source of overall heterogeneity. Sensitivity analysis supported this finding. Conclusion Ang-2 had high diagnostic accuracy for AP with OF; the best prediction of Ang-2 may be 24 to 72 hours after onset of AP.

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SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study

Gut ◽

10.1136/gutjnl-2020-323364 ◽

2021 ◽

pp. gutjnl-2020-323364

Author(s):

Sanjay Pandanaboyana ◽

John Moir ◽

John S Leeds ◽

Kofi Oppong ◽

Aditya Kanwar ◽

...

Keyword(s):

Acute Pancreatitis ◽

Hospital Stay ◽

Organ Failure ◽

Collaborative Study ◽

Length Of Hospital Stay ◽

Secondary Outcome ◽

Icu Admission ◽

Local Complications ◽

Persistent Organ Failure ◽

Increased Risk

ObjectiveThere is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.DesignA prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups.Results1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p<0.001). Unadjusted analysis showed that SARS-CoV-2-positive patients with AP were more likely to require ICU admission (OR 5.21, p<0.001), local complications (OR 2.91, p<0.001), persistent organ failure (OR 7.32, p<0.001), prolonged hospital stay (OR 1.89, p<0.001) and a higher 30-day mortality (OR 6.56, p<0.001). Adjusted analysis showed length of stay (OR 1.32, p<0.001), persistent organ failure (OR 2.77, p<0.003) and 30-day mortality (OR 2.41, p<0.04) were significantly higher in SARS-CoV-2 co-infection.ConclusionPatients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality.

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Sequential Organ Failure Assessment (SOFA) Score Is Superior to Classical Prognostic Indices in Prediction of Severity, Intensive Care Unit Admissions and Mortality in Acute Pancreatitis

HPB ◽

10.1016/j.hpb.2020.11.116 ◽

2021 ◽

Vol 23 ◽

pp. S48-S49

Author(s):

S. Baey ◽

T. Tan ◽

S.K. Gunasekaran ◽

S.P. Junnarkar ◽

J.K. Low ◽

...

Keyword(s):

Intensive Care Unit ◽

Acute Pancreatitis ◽

Intensive Care ◽

Sequential Organ Failure Assessment ◽

Organ Failure ◽

Sofa Score ◽

Failure Assessment ◽

Prognostic Indices

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Accuracy of conventional and novel scoring systems in predicting severity and outcomes of acute pancreatitis: a retrospective study

Lipids in Health and Disease ◽

10.1186/s12944-021-01470-4 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Qing Wu ◽

Jie Wang ◽

Mengbin Qin ◽

Huiying Yang ◽

Zhihai Liang ◽

...

Keyword(s):

Acute Pancreatitis ◽

Organ Failure ◽

Scoring System ◽

Characteristic Curve ◽

Failure Prediction ◽

Scoring Systems ◽

Mortality Prediction ◽

Severity Prediction ◽

Index Of Severity ◽

Glasgow Score

Abstract Background Recently, several novel scoring systems have been developed to evaluate the severity and outcomes of acute pancreatitis. This study aimed to compare the effectiveness of novel and conventional scoring systems in predicting the severity and outcomes of acute pancreatitis. Methods Patients treated between January 2003 and August 2020 were reviewed. The Ranson score (RS), Glasgow score (GS), bedside index of severity in acute pancreatitis (BISAP), pancreatic activity scoring system (PASS), and Chinese simple scoring system (CSSS) were determined within 48 h after admission. Multivariate logistic regression was used for severity, mortality, and organ failure prediction. Optimum cutoffs were identified using receiver operating characteristic curve analysis. Results A total of 1848 patients were included. The areas under the curve (AUCs) of RS, GS, BISAP, PASS, and CSSS for severity prediction were 0.861, 0.865, 0.829, 0.778, and 0.816, respectively. The corresponding AUCs for mortality prediction were 0.693, 0.736, 0.789, 0.858, and 0.759. The corresponding AUCs for acute respiratory distress syndrome prediction were 0.745, 0.784, 0.834, 0.936, and 0.820. Finally, the corresponding AUCs for acute renal failure prediction were 0.707, 0.734, 0.781, 0.868, and 0.816. Conclusions RS and GS predicted severity better than they predicted mortality and organ failure, while PASS predicted mortality and organ failure better. BISAP and CSSS performed equally well in severity and outcome predictions.

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IL-6 and APACHE II predict development of organ failure in acute pancreatitis: Prospective cohort study

Pancreatology ◽

10.1016/j.pan.2017.07.212 ◽

2017 ◽

Vol 17 (4) ◽

pp. S62

Author(s):

Rajendra Kumar Jain ◽

Saransh Jain ◽

Soumya Jagannath Mahapatra ◽

Shallu Midha ◽

Baibaswata Nayak ◽

...

Keyword(s):

Acute Pancreatitis ◽

Cohort Study ◽

Organ Failure ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Apache Ii

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Assessment of Prophylactic Carbapenem Antibiotics Administration for Severe Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis

Digestion ◽

10.1159/000520892 ◽

2022 ◽

pp. 1-9

Author(s):

Daxin Guo ◽

Wei Dai ◽

Jingyi Shen ◽

Mengting Zhang ◽

Yetan Shi ◽

...

Keyword(s):

Acute Pancreatitis ◽

Organ Failure ◽

Severe Acute Pancreatitis ◽

Pancreatic Pseudocyst ◽

Meta Analysis ◽

Fluid Collection ◽

Cochrane Library ◽

Intensive Care Unit Treatment ◽

Significant Difference ◽

And Control

Background: The effectiveness of prophylactic antibiotics in severe acute pancreatitis (SAP) remains a debatable issue. This meta-analysis aimed to determine the efficacy of prophylactic carbapenem antibiotics in SAP. Methods: This meta-analysis of prophylactic carbapenem antibiotics for SAP was conducted in PubMed, EMBASE, Web of Science, MEDLINE, and Cochrane Library up to February 2021. The related bibliographies were manually searched. The primary outcomes involved infected pancreatic or peripancreatic necrosis, mortality, complications, infections, and organ failure. Results: Seven articles comprised 5 randomized controlled trials and 2 retrospective observational studies, including 3,864 SAP participants. Prophylactic carbapenem antibiotics in SAP were associated with a statistically significant reduction in the incidence of infections (odds ratio [OR]: 0.27; p = 0.03) and complications (OR: 0.48; p = 0.009). Nevertheless, no statistically significant difference was demonstrated in the incidence of infected pancreatic or peripancreatic necrosis (OR: 0.74; p = 0.24), mortality (OR: 0.69; p = 0.17), extrapancreatic infection (OR: 0.64, p = 0.54), pulmonary infection (OR: 1.23; p = 0.69), blood infection (OR: 0.60; p = 0.35), urinary tract infection (OR: 0.97; p = 0.97), pancreatic pseudocyst (OR: 0.59; p = 0.28), fluid collection (OR: 0.91; p = 0.76), organ failure (OR: 0.63; p = 0.19), acute respiratory distress syndrome (OR: 0.80; p = 0.61), surgical intervention (OR: 0.97; p = 0.93), dialysis (OR: 2.34; p = 0.57), use of respirator or ventilator (OR: 1.90; p = 0.40), intensive care unit treatment (OR: 2.97; p = 0.18), and additional antibiotics (OR: 0.59; p = 0.28) between the experimental and control groups. Conclusions: It is not recommended to administer routine prophylactic carbapenem antibiotics in SAP.

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