Solubility of Nifedipine by Shake Flask UV-Spectrometry; Review of Safety Concerns in Pregnancy

Nifedipine is chemically dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, a dihydropyridine derivative used frequently as anti-hypertensive. It is a L- type calcium channel blocker (CCB). Few analogical discrepancies were found between Nifedipine’s clinical output report and chemical analysis of solubility. The ambition of this research is to conduct a re-check and proper quantification of partition co-efficient (logP) of Nifedipine and clarify the discrepancy and rectify if any mistake has been done in recent past. The method used is the “gold standard” shake-flask method followed by analysis through UV-scpectrophotmetry.

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M3, a 1,4-Dihydropyridine Derivative and Mixed L-/T-Type Calcium Channel Blocker, Attenuates Isoproterenol-Induced Toxicity in Male Wistar Rats

Cardiovascular Toxicology ◽

10.1007/s12012-020-09587-1 ◽

2020 ◽

Vol 20 (6) ◽

pp. 627-640

Author(s):

Oluwafemi Ezekiel Kale ◽

Miyase Gözde Gündüz ◽

Babafemi Tosin Ogunbiyi ◽

Temitope Funmi Ogundare ◽

Martins Ekor ◽

...

Keyword(s):

Calcium Channel ◽

Calcium Channel Blocker ◽

Wistar Rats ◽

Channel Blocker ◽

Dihydropyridine Derivative ◽

Male Wistar Rats

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Effects of a Novel Dihydropyridine Derivative Calcium Channel Blocker, NKY-722, on Regional Hemodynamics, and Its Influences on the Effects of Endothelin in Anesthetized Rats.

Hypertension Research ◽

10.1291/hypres.17.29 ◽

1994 ◽

Vol 17 (1) ◽

pp. 29-34 ◽

Cited By ~ 3

Author(s):

Hakuo Takahashi ◽

Shohei Nakamura ◽

Hiroaki Shirahase ◽

Masato Nishimura ◽

Tadashi Nakanishi ◽

...

Keyword(s):

Calcium Channel ◽

Calcium Channel Blocker ◽

Channel Blocker ◽

Anesthetized Rats ◽

Regional Hemodynamics ◽

Dihydropyridine Derivative

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Successful management of refractory hypertension with dual calcium channel blocker therapy: case presentation

Archives of Family Medicine ◽

10.1001/archfami.6.5.503 ◽

1997 ◽

Vol 6 (5) ◽

pp. 503-505

Author(s):

K. Geurian

Keyword(s):

Calcium Channel ◽

Calcium Channel Blocker ◽

Channel Blocker ◽

Successful Management ◽

Refractory Hypertension ◽

Case Presentation ◽

Blocker Therapy

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Chronic treatment by the calcium channel blocker ± PN 200-110 in the rat counteracts the stimulations of pituitary weight, prolactin release and pituitary C-kinase activity induced by a chronic estradiol treatment, in vivo

Acta Endocrinologica ◽

10.1530/acta.0.1220403 ◽

1990 ◽

Vol 122 (3) ◽

pp. 403-408

Author(s):

Ph. Touraine ◽

P. Birman ◽

F. Bai-Grenier ◽

C. Dubray ◽

F. Peillon ◽

...

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Calcium Channel ◽

Calcium Channel Blocker ◽

Channel Blocker ◽

Plasma Prolactin ◽

Estradiol Treatment ◽

Kinase C ◽

Protein Kinase C Activity

Abstract In order to investigate whether a calcium channel blocker could modulate the protein kinase C activity in normal and estradiol pretreated rat pituitary, female Wistar rats were treated or not (controls) with ± PN 200-110 (3 mg · kg−1 · day−1, sc) for 8 days or with estradiol cervical implants for 8 or 15 days, alone or in combination with PN 200-110 the last 8 days. Estradiol treatment induced a significant increase in plasma prolactin levels and pituitary weight. PN 200-110 administered to normal rats did not modify these parameters, whereas it reduced the effects of the 15 days estradiol treatment on prolactin levels (53.1 ± 4.9 vs 95.0 ±9.1 μg/l, p<0.0001) and pituitary weight (19.9 ± 0.4 vs 23.0 ± 0.6 mg, p <0.001), to values statistically comparable to those measured after 8 days of estradiol treatment. PN 200-110 alone did not induce any change in protein kinase C activity as compared with controls. In contrast, PN 200-110 treatment significantly counteracted the large increase in soluble activity and the decrease in the particulate one induced by estradiol between day 8 and day 15. We conclude that PN 200-110 opposed the stimulatory effects of chronic in vivo estradiol treatment on plasma prolactin levels and pituitary weight and that this regulation was related to a concomitant modulation of the protein kinase C activity.

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Effects of an Antihypertensive Combination in Japanese Hypertensive Outpatients Based on the Long-Acting Calcium Channel Blocker Benidipine on Vascular and Renal Events: A Sub-Analysis of the COPE Trial

Current Hypertension Reviews ◽

10.2174/1573402116666200129130151 ◽

2020 ◽

Vol 16 ◽

Author(s):

Seiji Umemoto ◽

Toshio Ogihara ◽

Masunori Matsuzaki ◽

Hiromi Rakugi ◽

Kazuyuki Shimada ◽

...

Keyword(s):

Blood Pressure ◽

Calcium Channel ◽

Calcium Channel Blocker ◽

Channel Blocker ◽

Rank Test ◽

Vascular Events ◽

Treatment Groups ◽

Β Blocker ◽

The Difference ◽

Long Acting

Background: In the trial known as COPE (Combination Therapy of Hypertension to Prevent Cardiovascular Events) three benidipine (a calcium channel blocker; CCB) regimens were compared. Hypertensive Japanese outpatients aged 40–85 years (n=3,293) who did not achieve the target blood pressure of <140/90 mmHg with benidipine 4 mg/day were treated with the diuretic thiazide (n=1,094) or a β-blocker (n=1,089) or an additional angiotensin receptor blocker (ARB; n=1,110). A significantly higher incidence of hard cardiovascular composite endpoints and of fatal or non-fatal strokes was observed in the benidipine-β-blocker group compared to the benidipine-thiazide group. Objective and Methods: We further evaluated the treatment effects of the three benidipine-based regimens on vascular and renal events in a sub-analysis of the COPE patients. Results: A total of 10 vascular events (0.8 per 1,000 person-years) including one aortic dissection (0.1 per 1,000 person-years) and nine cases of peripheral artery disease (0.8 per 1,000 person-years) were documented, as was a total of seven renal events (0.6 per 1,000 person-years). No significant differences in vascular and renal events were revealed among the three treatment groups: vascular events p=0.92 renal events p=0.16 log-rank test. Conclusions: Blood pressure-lowering therapy with benidipine combined with an ARB, β-blocker, or thiazide was similarly effective in the prevention of vascular and renal events in hypertensive outpatients, although there is no enough these events to compare the difference in the three treatment groups.

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