scholarly journals A Newly Improved Modified Method Development and Validation of Bromofenac Sodium Sesquihydrate in Bulk Drug Manufacturing

2016 ◽  
Vol 32 (5) ◽  
pp. 2297-2315
Author(s):  
Sunil V ◽  
Useni Mallu ◽  
I. Viswanath ◽  
D. Balasubramanyam ◽  
G. Murthy
Keyword(s):  
Method Development ◽  
Modified Method ◽  
Drug Manufacturing ◽  
Method Development And Validation ◽  
Bulk Drug ◽  
Development And Validation

Method development and validation: quantitation of telmisartan bulk drug and its tablet formulation by 1 H NMR spectroscopy

2017 ◽  
Vol 55 (7) ◽  
pp. 634-638 ◽  
Author(s):  
Yashwantsinh Jadeja ◽  
Bhagyawanti Chomal ◽  
Madhavi Patel ◽  
Hetal Jebaliya ◽  
Ranjan Khunt ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Method Development ◽  
Tablet Formulation ◽  
H Nmr ◽  
Method Development And Validation ◽  
Bulk Drug ◽  
Development And Validation

scholarly journals Method development and validation for simultaneous estimation of methotrexate and curcumin in Bulk Drug by using RP-HPLC

2019 ◽  
Vol 9 (6-s) ◽  
pp. 127-135
Author(s):  
Amar Deep Ankalgi ◽  
Nitin Kumar Chaudhary ◽  
Pooja Kaushal ◽  
Mahendra Singh Ashawat
Keyword(s):  
Method Development ◽  
Hplc Method ◽  
Simultaneous Estimation ◽  
Rp Hplc ◽  
Economic Method ◽  
Ich Guidelines ◽  
Method Development And Validation ◽  
Bulk Drug ◽  
Natural Herb ◽  
Development And Validation

Curcumin is the natural herb that shows effect in the treatment of cancer and rheumatoid arthritis and methotrexate is well known anticancer and anti-rheumatoid drug. Literature survey reveals that there was no method available for the selected drug combination. So, here an attempt has been made to develop simple, rapid and economic method for simultaneous estimation of methotrexate and curcumin in bulk drug by using RP-HPLC method. The percentage assay from optimized method was found to be 99.68% and 99.76% for methotrexate and curcumin respectively.  The proposed method was validated for  linearity, accuracy, precision and robustness according to ICH guidelines and were found to be   within the standard range. Keywords: RP- HPLC, methotrexate, Linearity, anticancer

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