Oxidative Coupling: A Tranquil Approach for Determination of Selexipag by Visible Spectrophotometry

2018 ◽  
Vol 34 (6) ◽  
pp. 3112-3117 ◽  
Author(s):  
Giri Prasad Gorumutchu ◽  
Venkata Nadh Ratnakaram
Keyword(s):  
Regression Analysis ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Spectrophotometric Method ◽  
Calibration Curve ◽  
Oxidative Coupling ◽  
Coupling Reaction ◽  
Oxidative Coupling Reaction ◽  
Pulmonary Arterial

The present study is a first report on development of a spectrophotometric method for determination of selexipag (used to cure pulmonary arterial hypertension) in bulk and tablet formulation and its validation. The basis of the proposed method is formation of a chromophore (of λ max 600 nm) in presence of acidic ferric chloride by oxidative coupling reaction between selexipag and MBTH (3-methylbenzo-thiazolin-2-one hydrazone) solution. Regression analysis (r > 0.999) shows that the plotted calibration curve exhibits good linearity in the studied range of concentration (5 – 30 μg mL-1). As per the existing guidelines of ICH, various parameters of the method were tested for validation. Low values of R.S.D. (< 2 %) were observed indicating that the proposed method is reproducible, accurate and precise.

scholarly journals Spectrophotmetric Micro determination of promrthazine hydrochloride in pharmaceutical

2021 ◽  
Vol 2 (3) ◽  
pp. 471-476
Author(s):  
Baghdad Science Journal
Keyword(s):  
Spectrophotometric Method ◽  
Oxidative Coupling ◽  
Coupling Reaction ◽  
Oxidative Coupling Reaction ◽  
Sensitive Spectrophotometric Method

a simple accurate and sensitive spectrophotometric method for the determination of promethazine HCI has been developed the method is based on the oxidative coupling reaction of promethazine

scholarly journals Spectrophotmetric Micro determination of promrthazine hydrochloride in pharmaceutical

2005 ◽  
Vol 2 (3) ◽  
pp. 471-476
Author(s):  
Baghdad Science Journal
Keyword(s):  
Spectrophotometric Method ◽  
Oxidative Coupling ◽  
Coupling Reaction ◽  
Oxidative Coupling Reaction ◽  
Sensitive Spectrophotometric Method

a simple accurate and sensitive spectrophotometric method for the determination of promethazine HCI has been developed the method is based on the oxidative coupling reaction of promethazine

scholarly journals Spectrophotometric method for the determination of benzocaine by cerium ammonium sulphate with promethazine hydrochloride in pure and phar-maceuticals preparation

2019 ◽  
Vol 10 (2) ◽  
pp. 1420-1423 ◽  
Author(s):  
Amal H. Mhemeed
Keyword(s):  
Ammonium Sulphate ◽  
Spectrophotometric Method ◽  
Oxidative Coupling ◽  
Pharmaceutical Preparation ◽  
Coupling Reaction ◽  
Molar Absorptivity ◽  
Oxidative Coupling Reaction ◽  
Promethazine Hydrochloride ◽  
Cerium Ammonium

Easy, the accurate, sensitive spectrophotometric method used to determine Benzocaine in a pure and pharmaceutical preparation. The proposed method depends on using Promethazine hydrochloride as a reagent. Where it depends on oxidative coupling reaction of benzocaine by cerium ammonium sulphate with promethazine hydrochloride in the presence of hydrochloric acid to form green dye product, lmax 615 nm. Beers law is obeyed in the concentration of (5 –300 µg.ml-1). The molar absorptivity is (1.77 * 10 3) L.mol -1.cm-1, a sandal sensitivity of (0.0098) µq.cm-2 and RSD (± 0.56 %). The method gave a successful determination for benzocaine in a pharmaceutical preparation.

scholarly journals SPECTROPHTOTOMETRIC DETERMINATION OF PURE SULFAMETHOXAZOLE IN PHARMACEUTICAL PREPARATIONS BY OXIDATIVE COUPLING REACTION

2021 ◽  
Vol 13 (1) ◽  
pp. 65-76
Author(s):  
Noor M. Ghaib Allah1 ◽  
Keyword(s):  
Correlation Coefficient ◽  
Spectrophotometric Method ◽  
Oxidative Coupling ◽  
Sulfonic Acid ◽  
Pharmaceutical Preparations ◽  
Coupling Reaction ◽  
Potassium Iodate ◽  
Oxidative Coupling Reaction ◽  
Sensitive Spectrophotometric Method

A new, simple, rapid and sensitive spectrophotometric method for the determination of sulfamethoxazole in both pure form and pharmaceutical preparations has been reported.The adapted technique based on utilization 4-aminobenzene sulfonic acid as a new modern chromogenic through an oxidative coupling reaction with sulfamethoxazole and potassium iodate in basic media to form orange soluble dye product with absorption maxima at 490 nm. Subject to Beer's law in the range 2–32μg mL-1. The values of molarabsorption coefficient (ε) and correlation coefficient were found to be 9.118 × 103 and0.9999 respectively whereas the Sandels index was 0. 02778 µg.cm-2

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