scholarly journals Sustainable Synthesis of Gold Nanoparticles and its Antidiabetic Activity of Anacardium Occidentale

2021 ◽  
Vol 37 (2) ◽  
pp. 374-379
Author(s):  
A. Leema Rose ◽  
F. Janeeta Priya ◽  
S. Vidhya
Keyword(s):  
Gold Nanoparticles ◽  
Antioxidant Activities ◽  
Spherical Shape ◽  
Building Blocks ◽  
Anacardium Occidentale ◽  
Antidiabetic Activity ◽  
Root Extract ◽  
Sem Image ◽  
Absorbance Peak ◽  
Aqueous Root Extract

Nanoparticles are being considered as elemental building blocks of nanotechnology. The green synthesis of gold nanoparticles using the aqueous root extract of Anacardium occidentale by bio-reduction of Auric chloride solution was investigated in the current study. The synthesized gold nanoparticles were characterized using UV-Visible spectroscopy, Fourier Transform Infrared spectroscopy and Scanning Electron Microscope. In UV, the absorbance peak was observed at 531nm, FTIR spectrum shows the wavelength range from 464.27 cm-1 to 3364.51cm-1 and SEM image showed that gold nanoparticles are in spherical shape. Then, the biosynthesized gold nanoparticles examined for the antidiabetic and antioxidant activities and the result outcome with better percentage of potential.

scholarly journals Antidiabetic activity of Pseudarthria viscida aqueous root extract in neonatal streptozotocin-induced NIDDM rats

2012 ◽  
Vol 22 (5) ◽  
pp. 1079-1084 ◽  
Author(s):  
Rajendran Kuppusamy ◽  
Annie Shirwaikar ◽  
Kishore G. Sam ◽  
Srinivasan K. Kaitheri
Keyword(s):  
Antidiabetic Activity ◽  
Root Extract ◽  
Aqueous Root Extract

scholarly journals Antidiabetic activity of aqueous root extract of Ichnocarpus frutescens in streptozotocin-nicotinamide induced type-II diabetes in rats

2008 ◽  
Vol 40 (1) ◽  
pp. 19 ◽  
Author(s):  
Rakesh Barik ◽  
Sanjay Jain ◽  
Deep Qwatra ◽  
Amit Joshi ◽  
GirrajSharan Tripathi ◽  
...  
Keyword(s):  
Type Ii Diabetes ◽  
Antidiabetic Activity ◽  
Root Extract ◽  
Type Ii ◽  
Ichnocarpus Frutescens ◽  
Aqueous Root Extract

Evaluation of in-vitro and in-vivo antidiabetic, antilipidemic and antioxidant potentials of aqueous root extract of Strophanthus hispidus DC (Apocynaceae)

2019 ◽  
Vol 16 (3) ◽  
Author(s):  
Muyiwa Samuel Fageyinbo ◽  
Abidemi James Akindele ◽  
Sunday Oluwaseun Adenekan ◽  
Esther Oluwatoyin Agbaje
Keyword(s):  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Diabetic Control ◽  
Antidiabetic Activity ◽  
Root Extract ◽  
Peak Reduction ◽  
Aqueous Root Extract

Abstract Background Antidiabetic activity of aqueous root extract of Strophanthus hispidus (SHP) was evaluated based on its folklore used in traditional medicine for the treatment of diabetes. Objectives: This study aimed to investigate the in-vitro and in-vivo antidiabetic potential of the aqueous root extract of SHP. Methods SHP (50, 100 and 200 mg/kg p.o.), glibenclamide (5 mg/kg p.o.), normal saline (10 mL/kg; diabetic control) and distilled water (10 mL/kg; normal control) were administered once daily for 28 days, with the measurement of fasting blood glucose level at 7 days interval. Blood samples were collected on day 28 for serum biochemical (albumin, total protein [TP], creatinine, alanine transaminase [ALT], aspartate transaminase [AST], alkaline phosphatase [ALP], triglycerides [TG], total cholesterol [TC], high-density lipoprotein [HDL], low-density lipoprotein [LDL], bilirubin and urea) and hematological assays. The in-vitro antidiabetic activity was investigated using α-amylase and α-glucosidase enzymes inhibitory assays. Results SHP produced a day-dependent reduction in glucose level. Peak reduction (82.94 %; p < 0.05) was produced at the dose of 100 mg/kg. SHP significantly (p < 0.05) increased the level of HDL and TP but significantly (p < 0.05) reduced the levels of TG, LDL, TC, AST, ALT, ALP, bilirubin, creatinine and urea compared with diabetic control rats. Furthermore, SHP significantly (p < 0.05) increased the level of catalase, superoxide dismutase and reduced glutathione compared to diabetic control rats. SHP significantly (p < 0.05) inhibited α-amylase and α-glucosidase enzymes compared with acarbose. Conclusion The findings in this study showed that SHP possesses beneficial antidiabetic activity.

scholarly journals GOLD NANOPARTICLES ENCAPSULATED IN A POLYMERIC MATRIX OF SODIUM ALGINATE

2016 ◽  
Vol 73 (2) ◽  
pp. 134
Author(s):  
Oana Lelia POP ◽  
Loredana Florina LEOPOLD ◽  
Olivia Dumitrita RUGINA ◽  
Zortia DIACONEASA ◽  
Ioana OPREA ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Confocal Microscopy ◽  
Sodium Alginate ◽  
Spherical Shape ◽  
Building Blocks ◽  
In Vitro Cytotoxicity ◽  
In Vitro Tests ◽  
Biologically Relevant ◽  
Cell Functions

Plasmonic nanoparticles can be used as building blocks for the design of multifunctional systems based on polymeric capsules. The use of functionalised particles in therapeutics and imaging and understanding their effect on the cell functions are among the current challenges in nanobiotechnology and nanomedicine. The aim of the study was to manufacture and characterize polymeric microstructures by encapsulating plasmonic gold nanoparticles in biocompatible matrix of sodium alginate. The gold nanoparticles were obtained by reduction of tetracluoroauric acid with sodium citrate. To characterize the microcapsules, UV-Vis and FTIR spectroscopy, optical and confocal microscopy experiments were performed. In vitro cytotoxicity tests on HFL-1 cells were also performed. The capsules have spherical shape and 120 μm diameter. The presence of encapsulated gold nanoparticles is also shown by confocal microscopy. In vitro tests show that the microcapsules are not cytotoxic upon 24 h of cells exposure to microcapsules concentrations ranging from 2.5 to 25 capsules per cell. The obtained microcapsules of sodium alginate loaded with plasmonic gold nanoparticles could potentially be considered as release systems for biologically relevant molecules.

Protective activities of the aqueous root extract of Harungana madagascariensis in acute and repeated acetaminophen hepatotoxic rats

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
AA Adeneye ◽  
JA Olagunju ◽  
SO Elias ◽  
OD Olatunbosun ◽  
AO Mustafa ◽  
...  
Keyword(s):  
Root Extract ◽  
Aqueous Root Extract

Assessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Gamze Göger ◽  
Muhammed Allak ◽  
Ali Şen ◽  
Fatih Göger ◽  
Mehmet Tekin ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Essential Oil ◽  
Antioxidant Activities ◽  
Antimicrobial Activities ◽  
Antidiabetic Activity ◽  
Gram Negative Bacteria ◽  
Inhibitory Effects ◽  
Dicaffeoylquinic Acid ◽  
Anti Inflammatory ◽  
Phytochemical Profiles

Abstract Phytochemical profiles of essential oil (EO), fatty acids, and n-hexane (CAH), diethyl ether (CAD), ethyl acetate (CAE) and methanol extracts (CAM) of Cota altissima L. J. Gay (syn. Anthemis altissima L.) were investigated as well as their antioxidant, anti-inflammatory, antidiabetic and antimicrobial activites. The essential oil was characterized by the content of acetophenone (35.8%) and β-caryophyllene (10.3%) by GC-MS/FID. Linoleic and oleic acid were found as main fatty acids. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, isorhamnetin glucoside, quercetin and quercetin glucoside by LC-MS/MS. Antioxidant activities of the extracts were determined by scavenging of DPPH and ABTS free radicals. Also, the inhibitory effects on lipoxygenase and α-glucosidase enzymes were determined. Antimicrobial activity was evaluated against Gram positive, Gram negative bacteria and yeast pathogens. CAM showed the highest antioxidant activity against DPPH and ABTS radicals with IC50 values of 126.60 and 144.40 μg/mL, respectively. In the anti-inflammatory activity, CAE demonstrated the highest antilipoxygenase activity with an IC50 value of 105.40 μg/mL, whereas, CAD showed the best inhibition of α-glucosidase with an IC50 value of 396.40 μg/mL in the antidiabetic activity. CAH was effective against Staphylococcus aureus at MIC = 312.5 µg/mL. This is the first report on antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of C. altissima.

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