Expression of Neural Cell Adhesion Molecule (NCAM) and Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Aganglionic Bowel of Hirschsprung's Disease

Author(s):  
Jung Tak Oh ◽  
Airi Han ◽  
Suk Woo Son ◽  
Seung Hoon Choi ◽  
Seok Joo Han ◽  
...  
1992 ◽  
Vol 16 (3) ◽  
pp. 307-315 ◽  
Author(s):  
Kalpana Patel ◽  
Graham Frost ◽  
Rosalind Rossell ◽  
Barry Pizer ◽  
Adrian Gee ◽  
...  

2011 ◽  
Vol 232 (2) ◽  
pp. 318-328 ◽  
Author(s):  
Bunmi Ojo ◽  
Payam Rezaie ◽  
Paul L. Gabbott ◽  
Thelma R. Cowely ◽  
Nikolay I. Medvedev ◽  
...  

1989 ◽  
Vol 169 (6) ◽  
pp. 2233-2238 ◽  
Author(s):  
L L Lanier ◽  
R Testi ◽  
J Bindl ◽  
J H Phillips

Neural cell adhesion molecule (N-CAM) is a membrane glycoprotein expressed on neural and muscle tissues that is involved in homotypic adhesive interactions. We have demonstrated that N-CAM also is expressed on hematopoietic cells, and is recognized by the anti-Leu-19 mAb. Leu-19 is preferentially expressed on NK cells and T lymphocytes that mediate MHC-unrestricted cytotoxicity, but is also present on some myeloid leukemia cell lines. On NK cells, T cells, the KG1a.5 hematopoietic cell line, and a neuroblastoma cell line, Leu-19 is a approximately 140-kD polypeptide with N-linked carbohydrates and abundant sialic acid residues. Sequential immunoprecipitation and peptide mapping demonstrated that the Leu-19 and N-CAM molecules expressed on leukocyte and neuroblastoma cell lines are similar structures. These findings suggest that the Leu-19 antigen on leukocytes may be involved in cell adhesion, analogous to the function on N-CAM on neural cells.


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