scholarly journals Effects of the Oxadiazine Insecticide, Indoxacarb, on Voltage-Gated Sodium Channels in Dorsal Unpaired Median Neurons Isolated from the American Cockroach, Periplaneta americana(Linnaeus)(Orhoptera: Blattidae).

2003 ◽  
Vol 47 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Yuji Tsurubuchi ◽  
Yoshiaki Kono
Keyword(s):  
Sodium Channels ◽  
Periplaneta Americana ◽  
American Cockroach ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
Dorsal Unpaired Median

The effects of huwentoxin-I on the voltage-gated sodium channels of rat hippocampal and cockroach dorsal unpaired median neurons

Peptides ◽  
2012 ◽  
Vol 34 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Meichi Wang ◽  
Mingqiang Rong ◽  
Yucheng Xiao ◽  
Songping Liang
Keyword(s):  
Sodium Channels ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
Dorsal Unpaired Median

A Possible Explanation for a Neurotoxic Effect of the Anticancer Agent Oxaliplatin on Neuronal Voltage-Gated Sodium Channels

2001 ◽  
Vol 85 (5) ◽  
pp. 2293-2297 ◽  
Author(s):  
Françoise Grolleau ◽  
Laurence Gamelin ◽  
Michèle Boisdron-Celle ◽  
Bruno Lapied ◽  
Marcel Pelhate ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Calcium Ions ◽  
Periplaneta Americana ◽  
Sodium Current ◽  
Current Amplitude ◽  
Patch Clamp Technique ◽  
Electrophysiological Properties ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
Whole Cell Patch Clamp

Oxaliplatin, a new widely used anticancer drug, displays frequent, sometimes severe, acute sensory neurotoxicity accompanied by neuromuscular signs that look like the symptoms observed in tetany and myotonia. The whole cell patch-clamp technique was employed to investigate the oxaliplatin effects on the electrophysiological properties of short-term cultured dorsal unpaired median (DUM) neurons isolated from the CNS of the cockroach Periplaneta americana. Within the clinical concentration range, oxaliplatin (40–500 μM), applied intracellularly, decreased the amplitude of the voltage-gated sodium current resulting in a reduction of half the amplitude of the action potential. For comparison, two other platinum derivatives, cisplatin and carboplatin, were found to be ineffective at reducing the sodium current amplitude. In addition, we compared the oxaliplatin action to those of its metabolites dichloro-diaminocyclohexane platinum (dach-Cl2-platin) and oxalate. Oxalate (500 μM) was found to be effective, like oxaliplatin, at reducing the inward sodium current amplitude, whereas dach-Cl2-platin (500 μM) failed to change the current amplitude. Interestingly, the effect of oxalate or oxaliplatin could be mimicked by using intracellularly applied 10 mM bis-( o-aminophenoxy)- N,N,N′,N′-tetraacetic acid (BAPTA), known as chelator of calcium ions. We concluded that oxaliplatin was capable of altering the voltage-gated sodium channels through a pathway involving calcium ions probably immobilized by its metabolite oxalate. The medical interest of preventing acute neurotoxic side effects of oxaliplatin by infusing Ca2+ and Mg2+ is discussed.

Voltage-Gated Sodium Channels and Pain

2004 ◽  
Vol 3 (6) ◽  
pp. 441-456 ◽  
Author(s):  
T. Priestley
Keyword(s):  
Sodium Channels ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels

Structural pharmacology of voltage-gated sodium channels

2021 ◽  
pp. 166967
Author(s):  
Sigrid Noreng ◽  
Tianbo Li ◽  
Jian Payandeh
Keyword(s):  
Sodium Channels ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels

scholarly journals Erratum to: Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?

2020 ◽  
Author(s):  
Zhi-mei Li ◽  
Li-xia Chen ◽  
Hua Li
Keyword(s):  
Open Access ◽  
Sodium Channels ◽  
Voltage Gated ◽  
Internet Portal ◽  
Creative Commons ◽  
Link Type ◽  
Voltage Gated Sodium Channels

The article “Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go?”, written by Zhi-mei LI, Li-xia CHEN, Hua LI, was originally published electronically on the publisher’s internet portal on December 2019 without open access. With the author(s)’ decision to opt for Open Choice, the copyright of the article is changed to © The Author(s) 2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The original article has been corrected.Corresponding authors: Li-xia CHEN, Hua LI

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