Anti-corrosion coating in desulphurization flue of one wet flue gas desulfurization equipment (FGD) (model 1 and model 2) was designed and studied according to environmental and technical parameters of a coal-fired power plant. And relevant design requirements were confirmed. Application results showed that polyureas has wear and high temperature physical properties, so that it can be used in flue desulfurization equipment for anticorrosion. When the construction of a thickness of 2.0 mm, the high-temperature polyureas protective coating appearance smooth, EDM(electric discharge machining) 100% pass rate, adhesion 10.8 MPa, at 160 °C environment still had outstanding performance, that make sure it could reach its design life of the flue based on estimating the corrosion margin.