scholarly journals Potentiometric Membrane Sensors for Levamisole Determination

2016 ◽  
Vol 6 (2) ◽  
pp. 7-14 ◽  
Author(s):  
Natalia Zubenya ◽  
Natalia Zubenya ◽  
Zholt Kormosh ◽  
Diana Saribekova ◽  
Diana Saribekova ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Thermal Analysis ◽  
Pharmaceutical Preparations ◽  
Ion Pair ◽  
Theoretical Interpretation ◽  
Pvc Membrane ◽  
Direct Potentiometry ◽  
Nernstian Slope ◽  
Three Stages ◽  
Selective Sensor

The ion pair (IP) of levamisole with BiI4 - (SbI4 - ) for the levamisole-selective sensor with a PVC membrane containing - ions were developed. Thermal behavior of obtained IP was investigated by differential thermal analysis that would show the thermal stability and the character of the decomposition of the complex. The thermolysis of Lev+BiI4 - IP undergoes three stages that fit a theoretical interpretation. The linearity ranges of levamisole sensors function are 7.9 ×10-6 – 1×10-1 (7.9 ×10-5 – 1×10-1 ) M. The Nernstian slope of 50.6 – 53.4 mV pC−1 and detection limit of 5.0 × 10−5 – 1.5 × 10−4) M. The working range of pH is 2.8 – 6.0. The efficiency of the use of electrodes for levamisole content control in pharmaceutical preparations was shown by direct potentiometry and potentiometric titration methods.

A Novel Potentiometric PVC-membrane Cysteamine-Selective Electrode Based on Cysteamine-Phosphomolybdate Ion-Pair

2020 ◽  
Vol 16 (2) ◽  
pp. 168-175 ◽  
Author(s):  
Merve Tumur ◽  
Gulsah Saydan Kanberoglu ◽  
Fatih Coldur
Keyword(s):  
Analytical Methods ◽  
Pharmaceutical Preparations ◽  
Life Time ◽  
Ion Pair ◽  
Pharmaceutical Formulation ◽  
Pvc Membrane ◽  
Selective Electrode ◽  
Potentiometric Response ◽  
Drug Quality Control

Background: Cysteamine is used as an orphan drug in the treatment of cystinosis to prevent long-term cystine accumulation in lysosomes. Dosing in cysteamine treatment is extremely important and overdose may cause some side effects. Up to now, various analytical methods have been used for cysteamine determination. Many of these methods require sophisticated instruments, expert operators, time-consuming measurement procedures and manipulation steps, expensive supplies and long analysis time. Aims and Objective: The present study deals with the development of a potentiometric PVC-membrane cysteamine-selective electrode based on an ion-pair of cysteamine and its application in a pharmaceutical formulation. Methods: Cysteamine (Cys)-Phosphomolybdate (PM) ion-pair was synthesized by mixing the equal volumes of 10-2 M Cysteamine HCl and sodium phosphomolybdate aqueous solutions. The obtained precipitate was used as ionophore in the structure of PVC-membrane. Results and Discussion: The electrode exhibited a linear response in the concentration range of 1.0×10- 1-1.0×10-5 M cysteamine with a slope of 51,7 mV per decade and detection limit of 1.0×10-5 M. The potentiometric response of the electrode was very rapid (5 s), adequately repeatable, stable and selective. pH working range and life-time of the electrode were also determined as 3.0-7.0 and 25 days, respectively. Conclusion: A PVC-membrane cysteamine selective electrode was easily prepared. Cysteamine determination in a pharmaceutical formulation was performed. Analysis results indicated that it can be successfully used in drug quality control laboratories for routine analysis of cysteamine in pharmaceutical preparations alternative to more sophisticated, expensive and time-consuming analytical methods.

scholarly journals Preparation, Characterization, and Analytical Application of Ramipril Membrane-Based Ion-Selective Electrode

2009 ◽  
Vol 2009 ◽  
pp. 1-7 ◽  
Author(s):  
Hassan Arida ◽  
Mona Ahmed ◽  
Abdallah Ali
Keyword(s):  
Pharmaceutical Formulations ◽  
Ion Pair ◽  
Pvc Membrane ◽  
Ion Selective Electrodes ◽  
Selective Electrode ◽  
Response Sensitivity ◽  
Direct Potentiometry ◽  
Plasticized Pvc ◽  
Electrochemical Evaluation

The fabrication and electrochemical evaluation of two PVC membrane-based Ion-Selective electrodes responsive for ramipril drug have been proposed. The sensitive membranes were prepared using ramipril-phosphomolibdate and ramipril-tetraphenylborate ion-pair complexes as electroactive sensing materials in plasticized PVC support. The electrodes based on these materials provide near-Nernestian response (sensitivity of53±0.5–54±0.5 mV/concentration decade) covering the concentration range of1.0×10-2–1.0×10-5 molL−1with a detection limit of3.0×10-6–4.0×10-6 molL−1. The suggested electrodes have been successfully used in the determination of ramipril drug in some pharmaceutical formulations using direct potentiometry with average recovery of >96% and mean standard deviation of <3% (n=5).

scholarly journals Thiocyanate Ion-Selective PVC Membrane Electrode

2010 ◽  
Vol 5 (1) ◽  
pp. 73-77
Author(s):  
Mihail Revenco ◽  
Mariana Martin ◽  
Waell Abu Dayyih
Keyword(s):  
Pvc Membrane ◽  
Indicator Electrode ◽  
Membrane Electrode ◽  
Thiocyanate Ion ◽  
Pvc Membrane Electrode ◽  
Wide Ph Range ◽  
Nernstian Slope ◽  
Ph Range ◽  
Discriminating Ability ◽  
Selective Sensor

A potentiometric selective sensor based on trinuclear chromium(III) complex as a novel ionophore for the thiocyanateselective electrode is reported. The sensor displays a near Nernstian slope of 57 ± 2 mV per decade, over a wide pH range 3 - 11. The working concentration range of the electrode is 1.10-5 – 1.10-1 mol/l with a detection limit of 5.10-6 mol/l. The sensor has a response time of 20 s and can be used for at least 6 months without any considerable fluctuation of the potential. The selectivity coefficients determined at using the fixed interference method indicate a good discriminating ability towards other anions. The prepared sensor was applied as an indicator electrode in the titration of thiocyanate with Ag+.

scholarly journals ION-SELECTIVE ELECTRODE FOR DETERMINATION OF METFORMIN IN PHARMACEUTICAL PREPARATIONS

2020 ◽  
pp. 124-129
Author(s):  
Геннадий Иванович Мантров ◽  
Мариана Александровна Феофанова ◽  
Егор Максимович Грачев
Keyword(s):  
Pharmaceutical Preparations ◽  
Ion Pair ◽  
Ion Selective Electrode ◽  
Selective Electrode ◽  
Electroactive Materials ◽  
Direct Potentiometry

Описана конструкция и электроаналитические характеристики ионселективного электрода (ИСЭ) для количественного определения метформина. В качестве электродноактивных соединений в ИСЭ были использованы ионные ассоциаты метформина с фосфорновольфрамовой(ФВК), фосфорномолибденовой(ФМК) и кремний вольфрамовой кислотами (КВК). Проведено потенциометрическое определение метформина в фармацевтических препаратах. The construction and electroanalytical characteristics of ion-selective electrode (ISE) for metformin are described. Ion pair of metformin with heteropolyacids were tested as electroactive materials for ionometric sensor controls. The ISE was used for direct potentiometry of metformin.

scholarly journals Etoricoxib selective sensor based on uracil-5,6-diamino-2-thio hydrochloride as neutral carrier for potentiometric analysis in pharmaceutical preparations

2016 ◽  
Vol 6 (2) ◽  
pp. 187
Author(s):  
Salwa Fares Rassi
Keyword(s):  
Direct Determination ◽  
Pharmaceutical Preparations ◽  
Ion Pair ◽  
Average Recovery ◽  
Relative Standard ◽  
Potentiometric Analysis ◽  
Long Lifetime ◽  
Excellent Stability ◽  
Selective Sensor

<em><span>A construction and electrochemical behavior of novel potentiometric membrane sensor responsive to the etoricoxib was described. The sensor was based on the ion-pair complex of etoricoxib (ET) with Uracil-5,6-diamino-2-thio hydrochloride UDTH (ET-UDTH) as exchange sites in a PVC matrix with different plasticizers dibutylphthalate (DBP) (electrode B) tri-n-butylphosphate (TBP) (electrode C), and dioctylphthalate (DOP) (electrode A). The electrodes exhibited near-Nernstian response for ET-UDTH over the concentration range 0.051-40.042 mM. The electrode offered significant advantages including long lifetime (about 2 months), excellent stability and reproducibility, good response time (10-25 s), and wide pH working range (pH 5-12). Selectivity coefficients of ET related to a number of interfering cation and some organic compounds were investigated, and there were negligible interference caused by most of the investigated species. The direct determination of 0.5-10 mM of ET showed an average recovery of 99.03-101.75% and a mean relative standard deviation 0.40-1.88. The results were obtained by determination of ET in tablets using the proposed electrodes which were comparable favorably with those obtained by spectrophotometric method</span></em>

Study of thermal stability of n-type skutterudites Sr0.07Ba0.07Yb0.07Co4Sb12 by differential thermal analysis and Knudsen effusion method

Calphad ◽  
2021 ◽  
Vol 73 ◽  
pp. 102258
Author(s):  
František Zelenka ◽  
Jakub Strádal ◽  
Pavel Brož ◽  
Jan Vřešťál ◽  
Jiří Buršík ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Thermal Analysis ◽  
Differential Thermal Analysis ◽  
Knudsen Effusion ◽  
Knudsen Effusion Method ◽  
Effusion Method ◽  
Thermal Stability Of

scholarly journals Potentiometric Surfactant Sensor Based on 1,3-Dihexadecyl-1H-benzo[d]imidazol-3-ium for Anionic Surfactants in Detergents and Household Care Products

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3627
Author(s):  
Nikola Sakač ◽  
Dubravka Madunić-Čačić ◽  
Dean Marković ◽  
Lucija Hok ◽  
Robert Vianello ◽  
...  
Keyword(s):  
Anionic Surfactants ◽  
Negative Impact ◽  
Ion Pair ◽  
Two Phase ◽  
Potentiometric Response ◽  
Titration Curves ◽  
Signal Change ◽  
Nernstian Slope ◽  
Good Agreement

A 1,3-dihexadecyl-1H-benzo[d]imidazol-3-ium-tetraphenylborate (DHBI-TPB) ion-pair implemented in DHBI-TPB surfactant sensor was used for the potentiometric quantification of anionic surfactants in detergents and commercial household care products. The DHBI-TPB ion-pair was characterized by FTIR spectroscopy and computational analysis which revealed a crucial contribution of the C–H∙∙∙π contacts for the optimal complex formation. The DHBI-TPB sensor potentiometric response showed excellent analytical properties and Nernstian slope for SDS (60.1 mV/decade) with LOD 3.2 × 10−7 M; and DBS (58.4 mV/decade) with LOD 6.1 × 10−7 M was obtained. The sensor possesses exceptional resistance to different organic and inorganic interferences in broad pH (2–10) range. DMIC used as a titrant demonstrated superior analytical performances for potentiometric titrations of SDS, compared to other tested cationic surfactants (DMIC > CTAB > CPC > Hyamine 1622). The combination of DHBI-TPB sensor and DMIC was successfully employed to perform titrations of the highly soluble alkane sulfonate homologues. Nonionic surfactants (increased concentration and number of EO groups) had a negative impact on anionic surfactant titration curves and a signal change. The DHBI-TPB sensor was effectively employed for the determination of technical grade anionic surfactants presenting the recoveries from 99.5 to 101.3%. The sensor was applied on twelve powered samples as well as liquid-gel and handwashing home care detergents containing anionic surfactants. The obtained results showed good agreement compared to the outcomes measured by ISE surfactant sensor and a two-phase titration method. The developed DHBI-TPB surfactant sensor could be used for quality control in industry and has great potential in environmental monitoring.

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