Synthetic approaches to [5,6]-benzannulated spiroketal natural products
2011 ◽
Vol 84
(6)
◽
pp. 1379-1390
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Keyword(s):
Studies toward the synthesis of three biologically active [5,6]-benzannulated spiroketal natural products are described. The first total synthesis of paecilospirone is reported, employing a late-stage, pH-neutral spiroketalization. A formal synthesis of γ-rubromycin is described, where the spiroketal moiety is formed by delicate manipulation of the electronic properties of the spirocyclization precursor. Finally, model work toward the total synthesis of berkelic acid is summarized, introducing a novel Horner–Wadsworth–Emmons/oxa-Michael (HWE/oxa-M) cascade to access the spiroketal precursor.
Expedient Access to Enantiopure Cyclopentanic Natural Products: Total Synthesis of (-)-Cyclonerodiol
2015 ◽
Vol 10
(1)
◽
pp. 1934578X1501000
2007 ◽
Vol 79
(2)
◽
pp. 163-172
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Keyword(s):
2013 ◽
Vol 8
(7)
◽
pp. 1934578X1300800
◽
1999 ◽
Vol 57
(9)
◽
pp. 736-748
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Keyword(s):
Keyword(s):
1988 ◽
Vol 46
(7)
◽
pp. 693-703
◽