Structure-activity relationships of acetylcholinesterase inhibitors: Donepezil hydrochloride for the treatment of Alzheimer’s Disease

1999 ◽  
Vol 71 (11) ◽  
pp. 2031-2037 ◽  
Author(s):  
H. Sugimoto
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Acetylcholinesterase Inhibitors ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Donepezil Hydrochloride

scholarly journals Structure–activity relationships of sulfonamides derived from carvacrol and their potential for the treatment of Alzheimer's disease

2020 ◽  
Vol 11 (2) ◽  
pp. 307-316
Author(s):  
Márcia Maria de Souza ◽  
Marina Corrêa Andreolla ◽  
Thaís Cecília Ribeiro ◽  
Ana Elisa Gonçalves ◽  
Alex Rogério Medeiros ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Target ◽  
Structure Activity Relationships ◽  
Structure Activity

We investigated the potential of sulfonamides derived from carvacrol as candidates for treatment of Alzheimer's disease. The results are very promising for the molecular target investigated as well as for the phenotypic assays.

Computational Studies on Acetylcholinesterase Inhibitors: From Biochemistry to Chemistry

2020 ◽  
Vol 20 (14) ◽  
pp. 1403-1435 ◽  
Author(s):  
Kiran Bagri ◽  
Ashwani Kumar ◽  
Manisha ◽  
Parvin Kumar
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Level ◽  
Acetylcholinesterase Inhibitors ◽  
Quantitative Structure Activity Relationship ◽  
Structural Features ◽  
Computational Studies ◽  
Disease Treatment ◽  
Pharmacophore Modelling ◽  
Structure Activity

Acetylcholinesterase inhibitors are the most promising therapeutics for Alzheimer’s disease treatment as these prevent the loss of acetylcholine and slows the progression of the disease. The drugs approved for the management of Alzheimer’s disease by the FDA are acetylcholinesterase inhibitors but are associated with side effects. Consistent and stringent efforts by the researchers with the help of computational methods opened new ways of developing novel molecules with good acetylcholinesterase inhibitory activity. In this manuscript, we reviewed the studies that identified the essential structural features of acetylcholinesterase inhibitors at the molecular level as well as the techniques like molecular docking, molecular dynamics, quantitative structure-activity relationship, virtual screening, and pharmacophore modelling that were used in designing these inhibitors.

Synthesis and structure–activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: high affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment

2021 ◽  
Author(s):  
William L. Neumann ◽  
Karin E. Sandoval ◽  
Shirin Mobayen ◽  
Mahsa Minaeian ◽  
Stephen G. Kukielski ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Somatostatin Receptor ◽  
Disease Treatment ◽  
Structure Activity Relationships ◽  
High Affinity ◽  
Structure Activity

3,4,5-Trisubstituted-1,2,4-triazole somatostatin receptor-4 agonist SAR.

Novel aspects in structure–activity relationships of profiled 1-aza-9-oxafluorenes as inhibitors of Alzheimer's disease-relevant kinases cdk1, cdk5 and gsk3β

MedChemComm ◽  
2012 ◽  
Vol 3 (11) ◽  
pp. 1413 ◽  
Author(s):  
Volkmar Tell ◽  
Kazem Ahmed Mahmoud ◽  
Kanin Wichapong ◽  
Christoph Schächtele ◽  
Frank Totzke ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Structure Activity Relationships ◽  
Structure Activity
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