scholarly journals The impact of social safety net scholarships program to school dropout rates in Indonesia: The intention-to-treat analysis

2017 ◽  
Vol 51 (4) ◽  
pp. 303-316 ◽  
Author(s):  
Bayu Kharisma ◽  
Elan Satriawan ◽  
Lincolin Arsyad
Keyword(s):  
School Dropout ◽  
Safety Net ◽  
Dropout Rates ◽  
Social Safety Net ◽  
Intention To Treat ◽  
The Impact ◽  
Treat Analysis

Caught in the Net: The Impact of Changes to Canadian Employment Insurance Legislation on Part-time Workers

2003 ◽  
Vol 2 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Norene Pupo ◽  
Ann Duffy
Keyword(s):  
Labour Force ◽  
Safety Net ◽  
Social Safety Net ◽  
Employment Insurance ◽  
The Social ◽  
Canadian Context ◽  
Insurance Programme ◽  
Part Time ◽  
Industrialised Countries ◽  
The Impact

Throughout Western highly industrialised countries, there has been a marked shift toward more conservative social policies signalling a dismantling of the welfare state as part of the process of globalisation. This paper examines the aetiology of the (un)employment insurance programme in the Canadian context. Recently, legislators have tightened eligibility rules, lowered earnings replacement rates and altered coverage requirements. While these changes signal a shredding of the social safety net, they differentially impact on certain segments of the population. Despite official pronouncements of fairness, employment insurance changes intensify the subordination women experience in the paid labour force.

Abstract 17169: The Impact of Renal Function on Outcomes With Edoxaban in the ENGAGE AF-TIMI 48 Trial

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Erin A Bohula ◽  
Robert P Giugliano ◽  
Christian T Ruff ◽  
Julia F Kuder ◽  
Sabina A Murphy ◽  
...  
Keyword(s):  
Renal Function ◽  
Clinical Outcome ◽  
Factor Xa ◽  
Intention To Treat ◽  
Significant Difference ◽  
Prevention Of Thromboembolic Events ◽  
Treatment Analysis ◽  
Net Clinical Benefit ◽  
The Impact ◽  
Treat Analysis

Background: Edoxaban (edox), an oral factor Xa inhibitor with 50% renal clearance, was non-inferior to warfarin for prevention of thromboembolic events and significantly reduced bleeding in pts with AF. However, a detailed analysis of the impact of creatinine clearance (CrCl) on clinical outcomes with edox has not been described. Purpose: We evaluated the safety, efficacy and net clinical outcome of edox vs warfarin (warf) across the range of baseline CrCl in the ENGAGE AF-TIMI 48 trial. Methods: 14,071 AF pts at moderate-to-high risk of stroke were randomized to edox 60mg QD or warf. Severe renal dysfunction (CrCl<30ml/min) was exclusionary and a CrCl 30-50 resulted in a 50% dose reduction of edox (30mg QD). Endpoints of stroke or systemic embolism (SSE), ISTH major bleeding (MB) and the primary net clinical outcome of SSE/MB and all-cause mortality (ACM) were evaluated by intention-to-treat analysis by the pre-specified singular CrCl cutpoint of 50ml/min and additional exploratory cutpoints. Results: The relative risk of SSE with edox vs warf in the pre-specified analysis in those with CrCl≤50 (HR 0.87, 0.65-1.18) was similar to those with CrCl>50 (HR 0.87, 0.72-1.04; p-int=0.94). Evaluation by more granular, exploratory cutpoints demonstrated higher rates of SSE (Fig 1a; p-int<0.001) and ischemic stroke (p-int=0.05) with edox vs warf in the upper range of CrCl, but lower rates of bleeding were observed at all levels of CrCl with edox (Fig 1a; p-int=0.39). For the net clinical outcome (SSE/MB/ACM), there was no significant difference between edox and warf at higher levels of renal function due to the preserved effect on bleeding and mortality (Fig 1b; p-int 0.17). An on-treatment analysis with plasma drug levels will be shown. Conclusion: While there is a trend towards decreasing efficacy with increasing CrCl for edox compared to well-managed warfarin, the overall safety and net clinical benefit of edox compared to warfarin is consistent across renal function groups.

Effectiveness, Safety, and Costs of Dolutegravir/Abacavir/Lamivudine Single-Tablet Regimen in a Real-Life Cohort of HIV-1 Adult Infected Patients

2020 ◽  
Vol 54 (7) ◽  
pp. 633-643
Author(s):  
Carmen Guadalupe Rodriguez-Gonzalez ◽  
Esther Chamorro-de-Vega ◽  
Cristina Ortega-Navarro ◽  
Roberto Alonso ◽  
Ana Herranz-Alonso ◽  
...  
Keyword(s):  
Cox Regression ◽  
Real Life ◽  
Pill Burden ◽  
Intention To Treat ◽  
Real Life Data ◽  
Single Tablet Regimen ◽  
Study Population ◽  
The Impact ◽  
Hiv 1 ◽  
Treat Analysis

Background: Real-life data on single-tablet regimen (STR) dolutegravir/abacavir/lamivudine (DTG/ABC/3TC) is scarce, and concerns about DTG neuropsychiatric adverse events (NP-AEs) have recently arisen. Objective: To explore the effectiveness and safety, in particular NP-AEs, of DTG/ABC/3TC in a cohort of HIV-1 adult infected patients. Pill burden, adherence to this STR, and the impact of switching on costs were also evaluated. Methods: This was an observational, retrospective study. The study population included antiretroviral therapy (ART)-naive and treatment-experienced (TE) patients who started DTG/ABC/3TC between February 1, 2016, and October 31, 2016. Effectiveness and safety were analyzed at week 48 (W48) by intention-to-treat analysis. The Cox regression model was used to investigate predictors of DTG/ABC/3TC discontinuation. Results: A total of 253 patients were included (44 ART naïve, 209 TE). At W48, the proportion of patients with virological suppression was 72.7% (95% CI = 58.4-87.0) in ART-naive patients, 85.6% (95% CI = 80.3-90.9) in previously suppressed TE patients, and 86.4% (95% CI = 65.1-97.1) in previously not suppressed TE patients. The rate of protocol-defined virological failure was 4.3%. The incidence of AEs was higher in the subgroup of ART-naive patients (56.1% vs 39.0%), with a rate of interruptions for this reason of 13.6% and 7.6%, respectively. The incidence of NP-AEs was 20.6%, with 3.9% of patients requiring discontinuation. Patients who had switched from a raltegravir-containing regimen discontinued DTG/ABC/3TC because of AEs more frequently (relative risk = 2.83; 95% CI = 1.04-7.72; P = 0.041) in the multivariate analysis. After switching to DTG/ABC/3TC, the median pill burden was reduced from 3 to 1 and the proportion of patients with an adherence <90%, from 20.1% to 12.0%. The annual per-patient ART costs increased by €48 (0.6% increase). Conclusion and Relevance: DTG/ABC/3TC is an effective strategy as first-line and switching ART. Our data suggest a worse tolerance in ART-naive patients, although the rate of discontinuation resulting from NP-AEs was relatively low. In the short-term, the adherence was slightly improved without significant changes in costs.

scholarly journals Potential of an Electronic Health Record-Integrated Patient Portal for Improving Care Plan Concordance during Acute Care

2019 ◽  
Vol 10 (03) ◽  
pp. 358-366 ◽  
Author(s):  
Anuj K. Dalal ◽  
Patricia Dykes ◽  
Lipika Samal ◽  
Kelly McNally ◽  
Eli Mlaver ◽  
...  
Keyword(s):  
Electronic Health Record ◽  
Acute Care ◽  
Transitions Of Care ◽  
Care Plan ◽  
Health Record ◽  
Patient Portal ◽  
Intention To Treat ◽  
Electronic Health ◽  
The Impact ◽  
Treat Analysis

Background Care plan concordance among patients and clinicians during hospitalization is suboptimal. Objective This article determines whether an electronic health record (EHR)-integrated patient portal was associated with increased understanding of the care plan, including the key recovery goal, among patients and clinicians in acute care setting. Methods The intervention included (1) a patient portal configured to solicit a single patient-designated recovery goal and display the care plan from the EHR for participating patients; and (2) an electronic care plan for all unit-based nurses that displays patient-inputted information, accessible to all clinicians via the EHR. Patients admitted to an oncology unit, including their nurses and physicians, were enrolled before and after implementation. Main outcomes included mean concordance scores for the overall care plan and individual care plan elements. Results Of 457 and 283 eligible patients approached during pre- and postintervention periods, 55 and 46 participated in interviews, respectively, including their clinicians. Of 46 postintervention patients, 27 (58.7%) enrolled in the patient portal. The intention-to-treat analysis demonstrated a nonsignificant increase in the mean concordance score for the overall care plan (62.0–67.1, adjusted p = 0.13), and significant increases in mean concordance scores for the recovery goal (30.3–57.7, adjusted p < 0.01) and main reason for hospitalization (58.6–79.2, adjusted p < 0.01). The on-treatment analysis of patient portal enrollees demonstrated significant increases in mean concordance scores for the overall care plan (61.9–70.0, adjusted p < 0.01), the recovery goal (30.4–66.8, adjusted p < 0.01), and main reason for hospitalization (58.3–81.7, adjusted p < 0.01), comparable to the intention-to-treat analysis. Conclusion Implementation of an EHR-integrated patient portal was associated with increased concordance for key care plan components. Future efforts should be directed at improving concordance for other care plan components and conducting larger, randomized studies to evaluate the impact on key outcomes during transitions of care. Clinical Trials Identifier NCT02258594.

Intention-to-treat analysis of liver transplantation for hepatocellular carcinoma: The impact of pre-existing diabetes mellitus

2018 ◽  
Vol 39 (2) ◽  
pp. 361-370 ◽  
Author(s):  
Zhiwei Li ◽  
Zhenzhen Gao ◽  
Jie Xiang ◽  
Jie Zhou ◽  
Sheng Yan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Intention To Treat ◽  
The Impact ◽  
Treat Analysis

scholarly journals Heterogeneity in the Impact of Economic Cycles and the Great Recession: Effects within and across the Income Distribution

2015 ◽  
Vol 105 (5) ◽  
pp. 154-160 ◽  
Author(s):  
Marianne Bitler ◽  
Hilary Hoynes
Keyword(s):  
Great Recession ◽  
Safety Net ◽  
Family Type ◽  
Social Safety Net ◽  
Demographic Groups ◽  
Economic Cycles ◽  
The Great Recession ◽  
The Social ◽  
Race Ethnicity ◽  
The Impact

In this paper, we examine the effects of economic cycles on low-to moderate-income families. We use variation across states and over time to estimate the effects of cycles on the distribution of income, using fine gradations of the household income-to-poverty ratio. We also explore how the effects of cycles affect the risk of falling into poverty across demographic groups, focusing on age, race/ethnicity, and family type. We conclude by testing to see whether these relationships have changed in the Great Recession. We discuss the results in light of the changes in the social safety net in recent decades.

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