Analgesic, anti-inflammatory and ulcerogenic studies of meloxicam solid dispersion prepared with polyethylene glycol 6000

2006 ◽  
Vol 28 (7) ◽  
pp. 419 ◽  
Author(s):  
S.G.V. Kumar ◽  
D.N. Mishra
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersion ◽  
Anti Inflammatory ◽  
Polyethylene Glycol 6000

Central composite designed solid dispersion for dissolution enhancement of fluvastatin sodium by kneading technique

2020 ◽  
Vol 11 (5) ◽  
pp. 313-328
Author(s):  
Sukhbir Singh ◽  
Neelam Sharma ◽  
Gurpreet Kaur
Keyword(s):  
Polyethylene Glycol ◽  
Drug Release ◽  
Central Composite Design ◽  
Solid Dispersion ◽  
Aqueous Solubility ◽  
Dissolution Enhancement ◽  
Saturation Solubility ◽  
Polyethylene Glycol 6000 ◽  
Central Composite

Aim: This research is focused on enhancing aqueous solubility and dissolution of fluvastatin sodium (FSS) through solid dispersion (FSS-SD) production using polyethylene glycol 6000 and polyvinyl pyrollidone K-30 by kneading technique. Methodology & results: Central composite design explored the influence of polyethylene glycol 6000 and polyvinyl pyrollidone K-30 on T50% and Q90. The aqueous saturation solubility of FSS (8.7 ± 1.12 μg/ml) was amplified 20-fold in FSS-SD (179 ± 4.16 μg/ml). Cumulative drug release from FSS and optimized FSS-SD were 27.49 and 87.4% within 90 min, respectively. Conclusion: FSS-SD production using kneading technique offers great prospective in maximizing FSS's solubility and dissolution.

scholarly journals KARAKTERISASI FISIKOKIMIA DAN LAJU DISOLUSI DISPERSI PADAT IBUPROFEN DENGAN PEMBAWA POLIETILENGLIKOL 6000

2015 ◽  
Vol 4 (1) ◽  
pp. 25
Author(s):  
Erizal Zaini ◽  
Rahmi x Rahmi Nofita ◽  
Salman ◽  
Irna Kurniati
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Polarized Light ◽  
Water Soluble ◽  
Dissolution Rates ◽  
Hot Stage Microscopy ◽  
Enhanced Dissolution ◽  
Water Soluble Compound ◽  
Polyethylene Glycol 6000

 Solid dispersions of the antiinflamation drug ibuprofen and polyethylene glycol 6000 (PEG 6000) were prepared by the melting method in order to increase the dissolution rates of this poorly water-soluble compound. The temperature/composition phase diagram of binary system was analyzed by termal analysis hot-stage microscopy, showing an eutectic formation. Polarized light hot stage microscopy and X-ray-powder diffraction confirmed, that solid dispersion technique decrease the crystalliny of ibuprofen after melting and solidifying of a 4/6 (w/w) mixture of ibuprofen and polyethylene glycol 6000 respectively, which the results enhanced dissolution rates compared to the physical mixtures and ibuprofen intact. However, no such chemical interactions in the solid state were confirmed by FTIR spectra which showed the presence of ibuprofen crystalline in solid dispersion.   

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