The effect of incorporation of indomethacin with polyethylene glycol 6000 in a solid dispersion on itsin vivo properties in the rat

1984 ◽  
Vol 15 (3-4) ◽  
pp. 367-370 ◽  
Author(s):  
Peter N. C. Elliott ◽  
James L. Ford ◽  
Kelvin K. C. Chan
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersion ◽  
Polyethylene Glycol 6000

Central composite designed solid dispersion for dissolution enhancement of fluvastatin sodium by kneading technique

2020 ◽  
Vol 11 (5) ◽  
pp. 313-328
Author(s):  
Sukhbir Singh ◽  
Neelam Sharma ◽  
Gurpreet Kaur
Keyword(s):  
Polyethylene Glycol ◽  
Drug Release ◽  
Central Composite Design ◽  
Solid Dispersion ◽  
Aqueous Solubility ◽  
Dissolution Enhancement ◽  
Saturation Solubility ◽  
Polyethylene Glycol 6000 ◽  
Central Composite

Aim: This research is focused on enhancing aqueous solubility and dissolution of fluvastatin sodium (FSS) through solid dispersion (FSS-SD) production using polyethylene glycol 6000 and polyvinyl pyrollidone K-30 by kneading technique. Methodology & results: Central composite design explored the influence of polyethylene glycol 6000 and polyvinyl pyrollidone K-30 on T50% and Q90. The aqueous saturation solubility of FSS (8.7 ± 1.12 μg/ml) was amplified 20-fold in FSS-SD (179 ± 4.16 μg/ml). Cumulative drug release from FSS and optimized FSS-SD were 27.49 and 87.4% within 90 min, respectively. Conclusion: FSS-SD production using kneading technique offers great prospective in maximizing FSS's solubility and dissolution.

scholarly journals KARAKTERISASI FISIKOKIMIA DAN LAJU DISOLUSI DISPERSI PADAT IBUPROFEN DENGAN PEMBAWA POLIETILENGLIKOL 6000

2015 ◽  
Vol 4 (1) ◽  
pp. 25
Author(s):  
Erizal Zaini ◽  
Rahmi x Rahmi Nofita ◽  
Salman ◽  
Irna Kurniati
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Polarized Light ◽  
Water Soluble ◽  
Dissolution Rates ◽  
Hot Stage Microscopy ◽  
Enhanced Dissolution ◽  
Water Soluble Compound ◽  
Polyethylene Glycol 6000

 Solid dispersions of the antiinflamation drug ibuprofen and polyethylene glycol 6000 (PEG 6000) were prepared by the melting method in order to increase the dissolution rates of this poorly water-soluble compound. The temperature/composition phase diagram of binary system was analyzed by termal analysis hot-stage microscopy, showing an eutectic formation. Polarized light hot stage microscopy and X-ray-powder diffraction confirmed, that solid dispersion technique decrease the crystalliny of ibuprofen after melting and solidifying of a 4/6 (w/w) mixture of ibuprofen and polyethylene glycol 6000 respectively, which the results enhanced dissolution rates compared to the physical mixtures and ibuprofen intact. However, no such chemical interactions in the solid state were confirmed by FTIR spectra which showed the presence of ibuprofen crystalline in solid dispersion.   

scholarly journals PENGARUH PENAMBAHAN POLIETILEN GLIKOL 6000 PADA TABLET IBUPROFEN DISPERSI PADAT TERHADAP ABSORBSI IBUPROFEN SECARA IN SITU

2021 ◽  
Vol 3 (3) ◽  
pp. 211-222
Author(s):  
Antetti Tampubolon
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersion ◽  
Male Rats ◽  
In Situ Methods ◽  
In Situ Absorption ◽  
Polyethylene Glycol 6000 ◽  
Drug Solution

Drug absorption can be decided by various methods, namely in vitro methods, in situ methods, and in vivo methods. The in situ method is a procedure that is very close to the in vivo method. The aim of this study was to identify the effect of accumulation of polyethylene glycol 6000 (PEG 6000) on solid dispersion of ibuprofen tablets on the in-situ absorption of the drug. This research was conducted through an experiment to determine the effect of adding polyethylene glycol 6000 to the absorption of ibuprofen in situ by flowing the solution from solid dispersion ibuprofen tablets, solutions from generic ibuprofen tablets and standard ibuprofen solutions. The solid dispersion system was carried out by melting ibuprofen and polyethylene glycol 6000 in a ratio of 1:05. The drug solution was flowed through the lumen of the small intestine of male rats. Unabsorbed ibuprofen was measured by an ultraviolet spectrophotometer at a wavelength of 225.5 nm. Next, the absorbed level of ibuprofen was calculated. The results showed that ibuprofen from solid dispersion tablets was absorbed more than ibuprofen from generic tablets and standard ibuprofen. It can be concluded that polyethylene glycol 6000 has an effect on the absorption of ibuprofen in situ.

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