scholarly journals Vitamin D and Calcium Supplementation Prevents Osteoporotic Fractures in Elderly Community Dwelling Residents: A Pragmatic Population-Based 3-Year Intervention Study

2003 ◽  
Vol 19 (3) ◽  
pp. 370-378 ◽  
Author(s):  
Erik Roj Larsen ◽  
Leif Mosekilde ◽  
Anders Foldspang
Keyword(s):  
Vitamin D ◽  
Intervention Study ◽  
Calcium Supplementation ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
Community Dwelling

scholarly journals Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

2011 ◽  
Vol 164 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Renate T de Jongh ◽  
Paul Lips ◽  
Kelly J Rijs ◽  
Natasja M van Schoor ◽  
Mark H H Kramer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Mortality Risk ◽  
Dna Analysis ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
Vdr Polymorphism ◽  
Hydroxyvitamin D ◽  
Increased Risk ◽  
Haplotype 1

ContextVitamin D receptor (VDR) polymorphisms are associated with a variety of diseases, which may translate into an effect on mortality.ObjectiveTo investigate the associations betweenVDRgene variants and mortality among older people.DesignThe analyses were conducted in a population-based, prospective cohort of the Longitudinal Aging Study Amsterdam. Adequate DNA analysis was performed in 923 men and women (≥65 years). We aimed to assess the associations between mortality and the VDR polymorphismFokI, three haplotypes of theCdx2andGATApolymorphisms, and three haplotypes of theBsmI,ApaI, andTaqIpolymorphisms.ResultsDuring the median follow-up of 10.7 years, 480 participants deceased (51%). Homozygosity for theCdx2–GATAhaplotype 1 allele was associated with a 30% higher mortality risk compared to the absence of alleles (hazard ratios (HR) 1.30, 95% confidence intervals (CI) 1.01–1.68). Adjustment for cardiovascular risk factors and 25-hydroxyvitamin D levels did not affect this HR. The number of copies of theCdx2–GATAhaplotype 1 allele was associated, although not significantly, with an increased risk of osteoporotic fractures (0 copies=reference, HR, 95% CI: 1 copy 2.01, 0.99–4.07 and 2 copies 1.81, 0.87–4.18). After adjustment for osteoporotic fractures, homozygosity for theCdx2–GATAhaplotype 1 allele was no longer associated with higher mortality risk (HR 1.08, 95% CI 0.83–1.41).ConclusionsTheCdx2–GATAhaplotype 1 allele was related to increased mortality risk, which may be partly explained by osteoporotic fractures. As the biological mechanism is uncertain and this study size is limited, our results should be interpreted as hypothesis generating.

Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals

2008 ◽  
Vol 20 (2) ◽  
pp. 315-322 ◽  
Author(s):  
M. Pfeifer ◽  
B. Begerow ◽  
H. W. Minne ◽  
K. Suppan ◽  
A. Fahrleitner-Pammer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Muscle Function ◽  
Calcium Supplementation ◽  
Community Dwelling ◽  
Older Individuals

scholarly journals 25-Hydroxyvitamin D and Risk of Osteoporotic Fractures: Mendelian Randomization Analysis in 2 Large Population-Based Cohorts

2020 ◽  
Vol 66 (5) ◽  
pp. 676-685 ◽  
Author(s):  
Yunus Çolak ◽  
Shoaib Afzal ◽  
Børge G Nordestgaard
Keyword(s):  
Vitamin D ◽  
Mendelian Randomization ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
Hydroxyvitamin D ◽  
Mendelian Randomization Analysis ◽  
Hazard Ratios ◽  
Increased Risk ◽  
25 Hydroxyvitamin D ◽  
Randomization Analysis

Abstract Background Whether low plasma 25-hydroxyvitamin D concentrations cause osteoporotic fractures is unclear. We tested the hypothesis that low plasma 25-hydroxyvitamin D concentrations are associated with increased risk of osteoporotic fractures using a Mendelian randomization analysis. Methods We genotyped 116 335 randomly chosen white Danish persons aged 20–100 years in 2 population-based cohort studies for plasma 25-hydroxyvitamin D decreasing genotypes in CYP2R1 (rs117913124 and rs12794714), DHCR7 (rs7944926 and rs11234027), GEMIN2 (rs2277458), and HAL (rs3819817); 35 833 had information on plasma 25-hydroxyvitamin D. We assessed risk of total, osteoporotic, and anatomically localized fractures from 1981 through 2017. Information on fractures and vital status was obtained from nationwide registries. Results During up to 36 years of follow-up, we observed 17 820 total fractures, 10 861 osteoporotic fractures, and 3472 fractures of hip or femur. Compared with individuals with 25-hydroxyvitamin D ≥ 50nmol/L, multivariable adjusted hazard ratios (95% CIs) for total fractures were 1.03 (0.97–1.09) for individuals with 25–49.9 nmol/L, 1.19 (1.10–1.28) for individuals with 12.5–24.9 nmol/L, and 1.39 (1.21–1.60) for individuals with 25-hydroxyvitamin D < 12.5 nmol/L. Corresponding hazard ratios were 1.07 (1.00–1.15), 1.25 (1.13–1.37), and 1.49 (1.25–1.77) for osteoporotic fractures and 1.09 (0.98–1.22), 1.37 (1.18–1.57), and 1.41 (1.09–1.81) for fractures of hip or femur, respectively. Hazard ratios per 1 increase in vitamin D allele score, corresponding to 3.0% (approximately 1.6 nmol/L) lower 25-hydroxyvitamin D concentrations, were 0.99 (0.98–1.00) for total fractures, 0.99 (0.97–1.00) for osteoporotic fractures, and 0.98 (0.95–1.00) for fractures of hip or femur. Conclusions Low plasma 25-hydroxyvitamin D concentrations were associated with osteoporotic fractures; however, Mendelian randomization analysis provided no evidence supporting a causal role for vitamin D in the risk for osteoporotic fractures.

Fracture Liaison Services - Polish Experience. Methods of Secondary Prevention of Osteoporotic Fractures

2016 ◽  
Vol 18 (6) ◽  
pp. 569-581 ◽  
Author(s):  
Jarosław Amarowicz ◽  
Edward Czerwiński ◽  
Katarzyna Zając ◽  
Anna Kumorek
Keyword(s):  
Vitamin D ◽  
Health Systems ◽  
Musculoskeletal Diseases ◽  
Calcium Supplementation ◽  
Osteoporotic Fractures ◽  
Quality Of Data ◽  
Clinical Criteria ◽  
Fracture Liaison Services ◽  
Number Of Patients ◽  
Fracture Liaison

Background. Fragility fractures are a major challenge to health systems around the world. The risk of a subsequent fracture may increase even 11-fold after one’s first fracture event. A coordinator-based system (Fracture Liaison Services) was established in Poland in order to fill the gap in the care of patients with osteoporotic fractures. In the past years, the FLS has become a crucial part of orthopaedic facilities worldwide, bringing benefits to patients and savings to health systems’ budgets. Material and methods. In 2015, the European Foundation of Osteoporosis and Musculoskeletal Diseases (EFOM) implemented the FLS in Poland under the name “System Zapobiegania Złamaniom (SZZ)”. It was established in 16 centres in different parts of Poland. During the preparation phase, 42 healthcare professionals from 17 sites participated in courses organized by EFOM. Results. A total of 1,579 patients were included in the SZZ, with a total of 746 DXA scans performed in that group. Patients were educated about osteoporotic fractures, including the methods of prevention (causes of fractures, problem of falls, vitamin D and calcium supplementation). The number of patients receiving antiresorptive treatment increased by 74.1%. The percentage of patients taking vitamin D and calcium supplements increased by an average of 10.8%. Although all the participating patients had suffered a fragility fracture, only 42% fulfilled the WHO clinical criteria for osteoporosis. Conclusions. 1. The implementation of the Fracture Liaison Service concept in Poland is possible and beneficial for the patients and healthcare system. 2. The current WHO definition of osteoporosis might be insufficient. 3. The use of an integrated database in different facilities, in terms of fracture epidemiology, significantly improves the quality of data being collected.

scholarly journals Association Between Vitamin D, Frailty, and Progression of Frailty in Community-Dwelling Older Women

2019 ◽  
Vol 104 (12) ◽  
pp. 6139-6147 ◽  
Author(s):  
David Buchebner ◽  
Patrik Bartosch ◽  
Linnea Malmgren ◽  
Fiona E McGuigan ◽  
Paul Gerdhem ◽  
...  
Keyword(s):  
Vitamin D ◽  
Older Women ◽  
Healthy Aging ◽  
Oldest Old ◽  
Frailty Index ◽  
Population Based ◽  
Community Dwelling ◽  
Increased Risk ◽  
And Function

Abstract Context Vitamin D (25OHD) is involved in many physiological functions that decline with age, contributing to frailty and increased risk for negative health outcomes. Whether 25OHD is a long-term risk marker for frailty over a longer time and whether it is consistent with advancing age is unclear. Objective To investigate the association between 25OHD and frailty in older women followed for 10 years. Design and Setting Prospective, population-based, cohort study in Malmö, Sweden. Participants Community-dwelling women, age 75 years (N = 1044) with reassessments at ages 80 (n = 715) and 85 (n = 382) years. Methods Frailty was quantified using a 10-variable frailty index. Women were categorized as 25OHD insufficient (<50 nmol/L) or sufficient (≥50 nmol/L). Results At ages 75 and 80 years, women with insufficient 25OHD were frailer than women with sufficient 25OHD (0.23 vs 0.18, P < 0.001; and 0.32 vs 0.25, P = 0.001, respectively). At age 80 years, 25OHD insufficiency was associated with subsequent frailty 5 years later (0.41 vs 0.32; P = 0.011). Accelerated progression of frailty was not associated with lower 25OHD levels, and 25OHD level >75 nmol/L was not additionally beneficial with regard to frailty. No association between 25OHD and frailty was observed at age 85 years. Within the frailty index, variables associated with 25OHD were related to muscle strength and function. Conclusion In this study, 25OHD insufficiency was associated with increased frailty in all but the oldest old. This study supports the value of maintaining sufficient 25OHD levels for healthy aging.

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