Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals

2008 ◽  
Vol 20 (2) ◽  
pp. 315-322 ◽  
Author(s):  
M. Pfeifer ◽  
B. Begerow ◽  
H. W. Minne ◽  
K. Suppan ◽  
A. Fahrleitner-Pammer ◽  
...  
Keyword(s):  
Vitamin D ◽  
Muscle Function ◽  
Calcium Supplementation ◽  
Community Dwelling ◽  
Older Individuals

Long-term strength training for community-dwelling people over 75: impact on muscle function, functional ability and life style

2006 ◽  
Vol 100 (5) ◽  
pp. 535-542 ◽  
Author(s):  
Paolo Capodaglio ◽  
Maria Capodaglio Edda ◽  
Marco Facioli ◽  
Francesco Saibene
Keyword(s):  
Strength Training ◽  
Functional Ability ◽  
Life Style ◽  
Muscle Function ◽  
Community Dwelling ◽  
Term Strength

scholarly journals Vitamin D and Physical Activity Status: Associations With Five-Year Changes in Body Composition and Muscle Function in Community-Dwelling Older Adults

2015 ◽  
Vol 100 (2) ◽  
pp. 670-678 ◽  
Author(s):  
David Scott ◽  
Peter R. Ebeling ◽  
Kerrie M. Sanders ◽  
Dawn Aitken ◽  
Tania Winzenberg ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Vitamin D ◽  
Body Composition ◽  
Body Fat ◽  
Muscle Function ◽  
Community Dwelling ◽  
Accelerometer Data ◽  
High Vitamin ◽  
Community Dwelling Older Adults

Abstract Context: High vitamin D and physical activity (PA) levels are independently associated with improved body composition and muscle function in older adults. Objective: The objective of this study was to investigate the interaction of 25-hydroxyvitamin D (25OHD) and PA status in maintenance of body composition and muscle function in older adults. Design and Setting: This was a 5-year prospective population-based study of Australian community-dwelling older adults. Participants: Participants in the study included 615 community-dwelling volunteers aged 50 years old or older [61.4 ± 6.9 (mean ± SD) y; 48% female] randomly selected from electoral rolls and categorized according to baseline serum 25OHD (≥ or <50 nmol/L) and PA (≥ or <10 000 pedometer determined steps/d) levels as follows: high 25OHD and high PA (VitD+PA+); high 25OHD and low PA (VitD+PA−); low 25OHD and high PA (VitD-PA+); and low 25OHD and low PA (VitD-PA−). A subset of 518 participants completed accelerometer assessments during follow-up. Main Outcome Measures: Changes in dual-energy X-ray absorptiometry-assessed body composition and lower-limb muscle function were measured. Results: VitD+PA+ had significantly smaller increases in body fat over 5 years compared with other groups (all P < .05). Higher baseline pedometer-determined PA resulted in declines in total body fat (β = −.23 kg per 100 steps/d, P = .001) over 5 years for participants with high 25OHD but not those with low 25OHD (P > .05). Among participants with accelerometer data, these associations were generally mediated by higher levels of moderate/vigorous PA. Conclusions: High vitamin D status appears to enhance PA-related declines in body fat during aging, but the mechanism may be greater amounts of outdoor moderate/vigorous PA rather than a direct effect of 25OHD.

scholarly journals Fibroblast Growth Factor-23 and the Long-Term Risk of Hospital-Associated AKI among Community-Dwelling Older Individuals

2013 ◽  
Vol 9 (2) ◽  
pp. 239-246 ◽  
Author(s):  
Jeremiah R. Brown ◽  
Ronit Katz ◽  
Joachim H. Ix ◽  
Ian H. de Boer ◽  
David S. Siscovick ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Community Dwelling ◽  
Fibroblast Growth ◽  
Older Individuals

scholarly journals Prevention of falls in old people – a review

2013 ◽  
Vol 23 (3) ◽  
pp. 206-222 ◽  
Author(s):  
Magnus K. Karlsson ◽  
Caroline Karlsson ◽  
Maria Cöster ◽  
Håkan Magnusson ◽  
Björn E. Rosengen
Keyword(s):  
Vitamin D ◽  
Older People ◽  
Fall Risk ◽  
Risk Groups ◽  
Vitamin D Supplementation ◽  
Community Dwelling ◽  
Older Individuals ◽  
Surgical Interventions ◽  
Healthy Community ◽  
Training Modalities

SummaryPhysical training, if including specific different training modalities, reduces the fall risk in healthy community-dwelling older people, as does a home hazards modification programme. Vitamin D supplementation in older individuals with low levels of vitamin D, adjustment of psychotropic medication, and structured modification of multi-pharmacy are all drug-focused programmes that reduce the number of falls. Anti-slip shoe devices during icy conditions for older people who walk outdoors and multifaceted podiatry in patients with specific foot disability reduce the fall risk. First eye cataract surgery and pacemakers in patients with cardio-inhibitory carotid sinus hypersensitivity are surgical interventions that reduce the fall risk. Multi-factorial preventive programmes that include training, both individually designed and generally prescribed, also reduce the fall frequency. With this in mind, we ought to initiate fall preventive programmes in older people, especially in high- risk groups, to reduce the number of falls and fallers in society.

scholarly journals Endocrinopathies Following Allogeneic Stem Cell Transplantation: 10 Years Follow-up in 402 Patients

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 4600-4600
Author(s):  
Maria Teresa Lupo Stanghellini ◽  
Giovanni Vita ◽  
Andrea Assanelli ◽  
Francesca Lorentino ◽  
Fabio Serpenti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Median Time ◽  
Allogeneic Stem Cell Transplantation ◽  
Calcium Supplementation ◽  
Specific Treatment ◽  
Oral Vitamin

Abstract Introduction Allogeneic stem cell transplantation (allo-HCT) survivors are at a defined relevant risk of developing long-term complications: the prevalence of chronic health conditions approaches 75% among HCT survivors. The endocrine system is one of the most frequent targets of complications, providing justification for a long-term and continuous follow-up (LTFU) to assure a timely and appropriate treatment. The aim of our study is to evaluate the incidence of endocrinopathies in survivors in respect of sex, age, donor type, conditioning regimen and GvHD occurrence. Methods A standardized LTFU is applied at our center. We here analyze data consecutively collected in an Institutional database, starting from 2006, including 402 adult patients (pts) who underwent an allo-HCT between 1992 and 2016 at our Institution. A written consent was given by pts allowing the use of medical records for research in accordance with the Declaration of Helsinki. We considered for the analysis pts with an overall survival >/=1y. We reviewed pts chapters with a focus on occurrence, management and treatment of diabetes, thyroid disfunctions, dyslipidemia and osteopenia / osteoporosis: diagnosis and follow-up were performed according to guidelines for long-term HCT survivors. Results With a median follow-up of 7y (r 2-25y) 328 pts were evaluable; donor was a match unrelated donor in 107 cases, HLA identical sibling in 88, haploidentical relative in 129 and cord blood in 4. The 5y-incidence of diabetes type 2 was 3%, with a median time after allo-HCT of 1138 days (r 5-4181 days); 13/22 developed diabetes after diagnosis of GvHD (median time 884 days, r 30-3753 days). All pts received indication for diet modification, 11 pts were treated with insulin and 8 pts with metformin. Thyroid disfunction was documented in 38 pts (5y-incidence 8,5%): 2 pts were diagnosed with hyperthyroidism and treated with methimazole or radioiodine treatment. Hypothyroidism was documented in 36 pts (median time after allo-HSCT 799 days, r 65-5021 days). Thirteen pts developed hypothyroidism following the diagnosis of GvHD (median time 1236 days, r 166-3540 days). Only 2 pts did not receive a specific treatment, while all the others received substitutive therapy with levothyroxine. Furthermore 1 pt was diagnosed with a papillary thyroid cancer. The 5y-incidende of dyslipidemia was 30% with a median time after allo-HSCT of 1433 days (r 366-7629), 47 pts developed dyslipidemia after the diagnosis of GVHD (median time 1425 days, r 134-7403 days). Diet-therapy was recommended to all the pts, 29 pts received a statin-based pharmacological treatment, 20 pts a polyenoic-fatty-acids based treatment, while a nutraceutical compound was given in 13 pts. Osteopenia was documented in 120 pts (median time after allo-HSCT 994 days, range 31-6605 days) with a 5y-incidence of 36%. Seventy-nine pts presented osteopenia after diagnosis of GvHD (median time after GvHD diagnosis 707 days, r 13-6379 days). Eight pts did not receive a specific treatment. Two pts received treatment with biphosphonates plus oral vitamin D and calcium supplementation, the 110 remaining pts received oral vitamin D +/- calcium supplementation only. Sixty-four pts developed osteoporosis (median time after allo-HSCT 1000 days, r 60-8836 days), the 5y-incidence was 26%. Forty-four pts developed osteoporosis following the diagnosis of GvHD (median time 724 days, r 28-8280 days). Only 4 pts did not receive any specific therapy; 31 pts received therapy with bisphosphonates, 2 pts denosumab and 27 pts oral vitamin D and calcium supplementation. In univariate analysis no relationship between host sex, age at transplant, TBI exposure, donor or history of GvHD and development of diabetes, thyroid disfunction and dyslipidemia was outlined. Otherwise, osteopenia development was strongly associated with GvHD occurrence and osteoporosis was strongly associated with age, sex and GvHD occurrence (table 1). Conclusions Allo-HCT survivors are at relevant risk of endocrinopathies after transplantation, providing justification for specific monitoring to individualize treatment and follow-up. Of note, classical transplant-related variables are not enough to justify the occurrence of endocrinological disfunction: a further deeper evaluation of a misdiagnosed donor-mediated autoimmune predisposition will be essential. Disclosures Bonini: Intellia Therapeutics: Research Funding.

scholarly journals Physical Activity and Cumulative Long-Term Care Cost among Older Japanese Adults: A Prospective Study in JAGES

2021 ◽  
Vol 18 (9) ◽  
pp. 5004
Author(s):  
Hiroshi Hirai ◽  
Masashige Saito ◽  
Naoki Kondo ◽  
Katsunori Kondo ◽  
Toshiyuki Ojima
Keyword(s):  
Physical Activity ◽  
Long Term Care ◽  
Evaluation Study ◽  
Community Dwelling ◽  
Older Individuals ◽  
Term Care ◽  
Cumulative Cost ◽  
Classical Linear Regression ◽  
The Impact

This study aimed to determine the impact of physical activity on the cumulative cost of long-term care insurance (LTCI) services in a cohort of community-dwelling people (65 years and older) in Japan. Using cohort data from the Japan Gerontological Evaluation Study (JAGES) on those who were functionally independent as of 2010/11, we examined differences in the cumulative cost of LTCI services by physical activity. We followed 38,875 participants with LTCI service costs for 59 months. Physical activity was assessed by the frequency of going out and time spent walking. We adopted a generalized linear model with gamma distribution and log-link function, and a classical linear regression with multiple imputation. The cumulative LTCI costs significantly decreased with the frequency of going out and the time spent walking after adjustment for baseline covariates. LTCI’s cumulative cost for those who went out once a week or less was USD 600 higher than those who went out almost daily. Furthermore, costs for those who walked for less than 30 min were USD 900 higher than those who walked for more than 60 min. Physical activity among older individuals can reduce LTCI costs, which could provide a rationale for expenditure intervention programs that promote physical activity.

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