scholarly journals Osteoporosis in Men and Women: A Story About Bone Mineral Density Thresholds and Hip Fracture Risk

2002 ◽  
Vol 17 (12) ◽  
pp. 2231-2236 ◽  
Author(s):  
Chris E. D. H. de Laet ◽  
Marjolein Van Der Klift ◽  
Albert Hofman ◽  
Huibert A. P. Pols
Keyword(s):  
Bone Mineral Density ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Mineral Density ◽  
Men And Women ◽  
Hip Fracture Risk ◽  
Osteoporosis In Men

Added value of bone mineral density in hip fracture risk scores

Bone ◽  
1999 ◽  
Vol 25 (3) ◽  
pp. 369-374 ◽  
Author(s):  
H Burger ◽  
C.E.D.H de Laet ◽  
A.E.A.M Weel ◽  
A Hofman ◽  
H.A.P Pols
Keyword(s):  
Bone Mineral Density ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Added Value ◽  
Risk Scores ◽  
Mineral Density ◽  
Hip Fracture Risk

scholarly journals The association of red blood cell n-3 and n-6 fatty acids with bone mineral density and hip fracture risk in the women's health initiative

2013 ◽  
Vol 28 (3) ◽  
pp. 505-515 ◽  
Author(s):  
Tonya S Orchard ◽  
Steven W Ing ◽  
Bo Lu ◽  
Martha A Belury ◽  
Karen Johnson ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Fatty Acids ◽  
Hip Fracture ◽  
Blood Cell ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Red Blood Cell ◽  
Mineral Density ◽  
Hip Fracture Risk ◽  
Health Initiative

A nomogram for predicting lifetime hip fracture risk from radius bone mineral density and age

Bone ◽  
1993 ◽  
Vol 14 (6) ◽  
pp. 843-846 ◽  
Author(s):  
V.J. Suman ◽  
E.J. Atkinson ◽  
W.M. O'fallon ◽  
D.M. Black ◽  
L.J. Melton III
Keyword(s):  
Bone Mineral Density ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Mineral Density ◽  
Hip Fracture Risk

Lifetime fracture risk: An approach to hip fracture risk assessment based on bone mineral density and age

1988 ◽  
Vol 41 (10) ◽  
pp. 985-994 ◽  
Author(s):  
L. Joseph^Melton ◽  
Stephen H. Kan ◽  
Heinz W. Wahner ◽  
B. Lawrence Riggs
Keyword(s):  
Bone Mineral Density ◽  
Risk Assessment ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Fracture Risk Assessment ◽  
Mineral Density ◽  
Hip Fracture Risk

scholarly journals Weight loss since early adulthood, later life risk of fracture hospitalizations, and bone mineral density: a prospective cohort study of 0.5 million Chinese adults

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Zewei Shen ◽  
◽  
Canqing Yu ◽  
Yu Guo ◽  
Zheng Bian ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Weight Loss ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Early Adulthood ◽  
Broadband Ultrasound Attenuation ◽  
Later Life ◽  
Mineral Density

Abstract Summary In a Chinese population from both urban and rural areas, weight loss of ≥ 5 kg from early adulthood to midlife was associated with a higher risk of hip fracture and lower BMD in later life. Introduction This study investigates the association of the long-term weight loss from young adulthood through the middle ages with the subsequent 10-year risk of hospitalized fracture and calcaneus bone mineral density (BMD). Methods China Kadoorie Biobank (CKB) was established during 2004–2008 in ten areas across China. Weight at age 25 years was self-reported at baseline, and weight at baseline and resurvey was measured by the calibrated equipment. Outcomes were hospitalized fracture during follow-up and calcaneus BMD measured at resurvey. Analysis for fracture risk included 411,812 participants who were free of fracture in the last 5 years before baseline, cancer, or stroke at any time before baseline. Analysis for BMD included 21,453 participants who participated in the resurvey of 2013–2014 with the same exclusion criteria as above. Results The mean age was 50.8 at baseline and 58.4 at resurvey. Median weight change from age 25 to baseline was 4.4 kg, with 20.7% losing weight and 58.5% gaining weight. During a median follow-up of 10.1 years, we documented 13,065 cases of first diagnosed fracture hospitalizations, including 1222 hip fracture. Compared with participants whose weight was stable (± 2.4 kg), the adjusted hazard ratios (95% CIs) for those with weight loss of ≥ 5.0 kg from age 25 to baseline was 1.39 (1.17 to 1.66) for hip fracture. Weight loss was not associated with fracture risk at other sites. Those with weight loss from age 25 to resurvey had the lowest BMD measures, with β (95% CIs) of − 4.52 (− 5.08 to − 3.96) for broadband ultrasound attenuation (BUA), − 4.83 (− 6.98, − 2.67) for speed of sound (SOS), and − 4.36 (− 5.22, − 3.49) for stiffness index (SI). Conclusions Weight loss from early adulthood to midlife was associated with a higher risk of hip fracture and lower BMD in later life.

scholarly journals Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women

2000 ◽  
Vol 71 (5) ◽  
pp. 1201-1208 ◽  
Author(s):  
Sarah L Booth ◽  
Katherine L Tucker ◽  
Honglei Chen ◽  
Marian T Hannan ◽  
David R Gagnon ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Hip Fracture ◽  
Bone Mineral ◽  
Vitamin K ◽  
Dietary Vitamin ◽  
Mineral Density ◽  
Elderly Men ◽  
Men And Women

scholarly journals POS1106 FRAX AND THE EFFECT OF TERIPARATIDE ON BONE MINERAL DENSITY IN SECONDARY OSTEOPOROSIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 833.2-834
Author(s):  
S. Garcia ◽  
B. M. Fernandes ◽  
M. Rato ◽  
F. Oliveira Pinheiro ◽  
D. Fonseca ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Hip Fracture ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Fracture Probability ◽  
Mineral Density ◽  
T Score

Background:Teriparatide has been shown to increase spine and hip bone mineral density (BMD) and to reduce vertebral and non-vertebral fractures. (1) It is currently not clear whether the effect of teriparatide is dependent on the baseline risk of fracture or osteoporosis (OP) type, a finding that could have an impact on our therapeutic decision.Objectives:Investigate if there is a relationship between teriparatide effect in BMD and baseline 10-year fracture probability, assessed using FRAX®, in primary and secondary OP patients.Methods:This is a longitudinal, retrospective study including consecutive patients with the diagnosis of OP treated with teriparatide for 24 months, with a ten-year follow-up period, at our rheumatology department. Demographic, clinical, laboratorial, BMD and occurrence of fracture data were collected. The 10-year risk of osteoporotic fracture was estimated using the fracture risk assessment tool (FRAX) v 4.1 with the Portuguese population reference. Statistical analysis was performed using the software SPSS 23.0. Correlations between continuous variables were evaluated with spearman coefficient. p<0.05 was considered statistically significant.Results:Eighty patients (88.8% female, median age 65.00 (59; 75)) were included. Forty-nine patients (61.3%) has secondary OP, mainly of cortisonic etiology (61.2%, n=30). Before treatment, median lumbar spine BMD was 0.870 [0.767, 0.964] g/cm2, median T-score of -2.60 (-3.30, -1.90); median total femur BMD was 0.742 [0.667, 0.863] g/cm2, median T-score of -2.10 (-2.80, -1.30); median femoral neck BMD was 0.671 [0.611, 0.787] g/cm2, median T-score of -2.50 [-3.20, -1.85]. Regarding fracture risk, median FRAX-based 10-year major fracture risk (with BMD) at baseline was 16% [10.0; 23], and median hip fracture risk was 7.2% [3.4; 13.8].The median variation of BMD, after finishing teriparatide treatment, in the spine was 0.107 [0.029; 0.228]; median BMD variation in total femur was 0.013 [-0.013; 0.068] and median BMD femoral neck was 0.046 [-0.002; 0.109]. We observed a numerically superior effect, albeit without any statistical significance, of teriparatide on bone mineral density gain in secondary OP (versus primary OP) at lumbar spine, total femur and femoral neck.Most patients continued anti-osteoporotic treatment with a bisphosphonate (81.2%, n=65) and, during follow-up, 17 patients had an incident fracture (8 hip fractures and 6 vertebral fractures), median of 5 [1.75, 8.25] years after ending teriparatide.We found a discrete correlation between FRAX-based hip fracture probability and the variation of bone mineral density in total femur (Spearman’s coefficient 0.248, p = 0.04). There was no correlation between FRAX-based major fracture probability and and the variation of bone mineral density in the spine or femur. When we separately analyze the relationship between the variation in total hip BMD and the FRAX-based fracture risk, depending on whether it is a secondary or primary OP, we find that the correlation is stronger and only remains in secondary OP (Spearman’s coefficient 0.348, p = 0.03).Conclusion:Our data suggest that teriparatide could be an important weapon in the treatment of secondary cause OP, particularly cortisonic, and in patients at high fracture risk, although further larger studies are needed to confirm these findings.References:[1]Kendler DL, Marin F, Zerbini CAF, Russo LA, Greenspan SL, Zikan V, Bagur A, Malouf-Sierra J, Lakatos P, Fahrleitner-Pammer A, Lespessailles E, Minisola S, Body JJ, Geusens P, Möricke R, López-Romero P. Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet. 2018 Jan 20;391(10117):230-240. doi: 10.1016/S0140-6736(17)32137-2.Disclosure of Interests:None declared.

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