Label-free Measurement of DNA Oligomer Binding Using a Highly-sensitive Photonic Crystal Biosensor

2010 ◽  
Author(s):  
Yunbo Guo ◽  
Jing Yong Ye ◽  
Thommey P. Thomas ◽  
James R. Baker ◽  
Theodore B. Norris
Keyword(s):  
Photonic Crystal ◽  
Label Free ◽  
Highly Sensitive

Hierarchical optical antenna: Gold nanoparticle-modified photonic crystal for highly-sensitive label-free DNA detection

2012 ◽  
Vol 22 (16) ◽  
pp. 8127 ◽  
Author(s):  
Weizhi Shen ◽  
Mingzhu Li ◽  
Benli Wang ◽  
Jian Liu ◽  
Zhiyuan Li ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Gold Nanoparticle ◽  
Dna Detection ◽  
Optical Antenna ◽  
Label Free ◽  
Free Dna ◽  
Highly Sensitive

Resonant Microcavities Coupled to a Photonic Crystal Waveguide for Multi-channel Biodetection

2009 ◽  
Vol 1191 ◽  
Author(s):  
Elisa Guillermain ◽  
Philippe M. Fauchet
Keyword(s):  
Photonic Crystal ◽  
Food Safety ◽  
Transmission Spectrum ◽  
Channel Structure ◽  
Photonic Crystal Waveguide ◽  
Label Free ◽  
Highly Sensitive ◽  
Fabrication And Characterization ◽  
Double Channel

AbstractMiniaturized and highly sensitive bio-sensors are attractive in various applications, such as medicine or food safety. Photonic crystal (PhC) microcavities present multiple advantages for rapid and accurate label-free optical detection. But their principle of operation (i.e. observation of a peak in transmission) makes their integration in serial arrays difficult. We present in this paper a multi-channel sensor consisting of several resonant PhC microcavities coupled to the same waveguide. The transmission spectrum shows as many dips as there are cavities, and each of the microcavities can act as an independent sensor. Preliminary results show the fabrication and characterization of a double-channel structure with small defects used as a solvent sensor.

scholarly journals Multiparametric detection of bacterial contamination based on the photonic crystal surface mode detection

2018 ◽  
pp. 19-24
Author(s):  
I. O. Petrova ◽  
V. N. Konopsky ◽  
A. V. Sukhanova ◽  
I. R. Nabiev
Keyword(s):  
Photonic Crystal ◽  
Crystal Surface ◽  
Surface Mode ◽  
Label Free ◽  
Water Quality Control ◽  
Analytical Technique ◽  
Mode Detection ◽  
Highly Sensitive ◽  
Cell Affinity ◽  
Detection Of Biomarkers

Conventional techniques for food and water quality control and environmental monitoring in general have a number of drawbacks. Below we propose a label-free highly accurate analytical technique for multiplex detection of biomarkers based on the analysis of propagation of Bloch waves on the surface of a photonic crystal. The technique can be used to measure molecular and cell affinity interactions in real time by recording critical and excitation angles of the surface wave on the surface of a photonic crystal. Based on the analysis of photonic crystal surface modes, we elaborated a protocol for the detection of the exotoxin A of Pseudomonas aeruginosa and the heat-labile toxin LT of Escherichia coli. The protocol exploits detection of affinity interactions between antigens pumped through a microfluidic cell and detector antibodies conjugated to the chemically activated silica chip. The proposed technique is highly sensitive, cheap and less time-consuming in comparison with surface plasmon resonance.

scholarly journals Photonic Crystal Nanobeam Cavities for Nanoscale Optical Sensing: A Review

Micromachines ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 72 ◽  
Author(s):  
Da-Quan Yang ◽  
Bing Duan ◽  
Xiao Liu ◽  
Ai-Qiang Wang ◽  
Xiao-Gang Li ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Optical Waveguides ◽  
Optical Sensing ◽  
Early Stage ◽  
Disease Diagnosis ◽  
Label Free ◽  
Quality Factors ◽  
Integrated Sensor ◽  
Early Stage Disease ◽  
Wide Range

The ability to detect nanoscale objects is particular crucial for a wide range of applications, such as environmental protection, early-stage disease diagnosis and drug discovery. Photonic crystal nanobeam cavity (PCNC) sensors have attracted great attention due to high-quality factors and small-mode volumes (Q/V) and good on-chip integrability with optical waveguides/circuits. In this review, we focus on nanoscale optical sensing based on PCNC sensors, including ultrahigh figure of merit (FOM) sensing, single nanoparticle trapping, label-free molecule detection and an integrated sensor array for multiplexed sensing. We believe that the PCNC sensors featuring ultracompact footprint, high monolithic integration capability, fast response and ultrahigh sensitivity sensing ability, etc., will provide a promising platform for further developing lab-on-a-chip devices for biosensing and other functionalities.

scholarly journals Optical Monitoring of the Production Quality of Si-Nanoribbon Chips Intended for the Detection of ASD-Associated Oligonucleotides

Micromachines ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 147
Author(s):  
Kristina A. Malsagova ◽  
Tatyana O. Pleshakova ◽  
Vladimir P. Popov ◽  
Igor N. Kupriyanov ◽  
Rafael A. Galiullin ◽  
...  
Keyword(s):  
Production Quality ◽  
Autism Spectrum ◽  
Covalent Immobilization ◽  
Biological Macromolecules ◽  
Label Free ◽  
Raman Scattering Spectroscopy ◽  
Dna Oligonucleotides ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

Gas-phase etching and optical lithography were employed for the fabrication of a silicon nanoribbon chip (Si-NR chip). The quality of the so-fabricated silicon nanoribbons (Si-NRs) was monitored by optical Raman scattering spectroscopy. It was demonstrated that the structures of the Si-NRs were virtually defect-free, meaning they could be used for highly sensitive detection of biological macromolecules. The Si-NR chips were then used for the highly sensitive nanoelectronics detection of DNA oligonucleotides (oDNAs), which represent synthetic analogs of 106a-5p microRNA (miR-106a-5p), associated with the development of autism spectrum disorders in children. The specificity of the analysis was attained by the sensitization of the Si-NR chip sur-face by covalent immobilization of oDNA probes, whose nucleotide sequence was complementary to the known sequence of miR-106a-5p. The use of the Si-NR chip was demonstrated to al-low for the rapid label-free real-time detection of oDNA at ultra-low (~10−17 M) concentrations.

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