Label-free biosensors based on athermal silicon-on-insulator waveguides and a harmonic dithering technique

2012 ◽  
Author(s):  
Kangbaek Kim ◽  
Robert M. Pafchek ◽  
Thomas L. Koch
Keyword(s):  
Silicon On Insulator ◽  
Label Free

Sensitive label-free and compact biosensor based on concentric silicon-on-insulator microring resonators

2009 ◽  
Vol 48 (25) ◽  
pp. F90 ◽  
Author(s):  
Xiaohui Li ◽  
Ziyang Zhang ◽  
Shenying Qin ◽  
Tao Wang ◽  
Fangfei Liu ◽  
...  
Keyword(s):  
Silicon On Insulator ◽  
Microring Resonators ◽  
Label Free

scholarly journals Compact Inner-Wall Grating Slot Microring Resonator for Label-Free Sensing

Sensors ◽  
2019 ◽  
Vol 19 (22) ◽  
pp. 5038 ◽  
Author(s):  
Hongjun Gu ◽  
He Gong ◽  
Chunxue Wang ◽  
Xiaoqiang Sun ◽  
Xibin Wang ◽  
...  
Keyword(s):  
Refractive Index ◽  
Sodium Chloride ◽  
High Sensitivity ◽  
Microring Resonator ◽  
Silicon On Insulator ◽  
Label Free ◽  
Detection Range ◽  
Sodium Chloride Solutions ◽  
Sensing Application ◽  
Index Unit

In this paper, we present and analyze a compact inner-wall grating slot microring resonator (IG-SMRR) with the footprint of less than 13 μm × 13 μm on the silicon-on-insulator (SOI) platform for label-free sensing, which comprises a slot microring resonator (SMRR) and inner-wall grating (IG). Its detection range is significantly enhanced without the limitation of the free spectral region (FSR) owing to the combination of SMRR and IG. The IG-SMRR has an ultra-large quasi-FSR of 84.5 nm as the detection range, and enlarged factor is up to over 3 compared with the conventional SMRR. The concentration sensitivities of sodium chloride solutions and D-glucose solutions are 996.91 pm/% and 968.05 pm/%, respectively, and the corresponding refractive index (RI) sensitivities are 559.5 nm/RIU (refractive index unit) and 558.3 nm/RIU, respectively. The investigation on the combination of SMRR and IG is a valuable exploration of label-free sensing application for ultra-large detection range and ultra-high sensitivity in future.

scholarly journals Label-free biosensors on silicon-on-insulator optical chips

2009 ◽  
Author(s):  
Katrien De Vos ◽  
Peter Debackere ◽  
Tom Claes ◽  
Jordi Girones ◽  
Wout De Cort ◽  
...  
Keyword(s):  
Silicon On Insulator ◽  
Label Free

Label-free Biosensor Based on Silicon-On-Insulator Concentric Micro-Ring Resonators

2008 ◽  
Author(s):  
Xiaohui Li ◽  
Yikai Su ◽  
Ziyang Zhang ◽  
Min Qiu ◽  
Shengying Qin
Keyword(s):  
Silicon On Insulator ◽  
Ring Resonators ◽  
Label Free

A SOI-nanowire biosensor for the multiple detection of D-NFATc1 protein in the serum

2015 ◽  
Vol 7 (19) ◽  
pp. 8078-8085 ◽  
Author(s):  
Kristina A. Malsagova ◽  
Yuri D. Ivanov ◽  
Tatyana O. Pleshakova ◽  
Anna L. Kaysheva ◽  
Ivan D. Shumov ◽  
...  
Keyword(s):  
Real Time ◽  
Silicon On Insulator ◽  
Label Free ◽  
Cancer Marker ◽  
Multiple Detection

Aptamer-functionalized silicon-on-insulator nanowires were used for the label-free, real-time biospecific detection of the cancer marker D-NFATc1 protein in the serum.

scholarly journals Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach

2010 ◽  
Vol 35 (16) ◽  
pp. 2771 ◽  
Author(s):  
D.-X. Xu ◽  
M. Vachon ◽  
A. Densmore ◽  
R. Ma ◽  
A. Delâge ◽  
...  
Keyword(s):  
Silicon On Insulator ◽  
Ring Resonators ◽  
Label Free ◽  
Biosensor Array

scholarly journals SOI-nanowire biosensor for the detection of D-NFAT 1 protein

2015 ◽  
Vol 61 (4) ◽  
pp. 462-467 ◽  
Author(s):  
K.A. Malsagova ◽  
Yu.D. Ivanov ◽  
T.O. Pleshakova ◽  
A.F. Kozlov ◽  
N.V. Krohin ◽  
...  
Keyword(s):  
Real Time ◽  
Molecular Probes ◽  
Silicon On Insulator ◽  
Label Free ◽  
Immobilized Antibodies ◽  
Disease Diagnostics ◽  
Label Free Detection ◽  
Protein Molecules ◽  
Fast Acting

The nanowire (NW) detection is one of fast-acting and high-sensitive methods allowing to reveal potentially relevant protein molecules. A NW biosensor based on the silicon-on-insulator (SOI)-structures was used for biospecific label-free detection of NFAT 1 (D-NFAT 1) oncomarker in real time. For this purpose, SOI-nanowires (NWs) were modified with aptamers against NFAT 1 used as molecular probes. It was shown that using this biosensor it is possible to reach the sensitivity of ~10-15 M. This sensitivity was comparable with that of the NW biosensor with immobilized antibodies used as macromolecular probes. The results demonstrate promising approaches used to form the sensor elements for high-sensitive disease diagnostics

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