scholarly journals CEACAM1 in Cervical Cancer and Precursor Lesions: Association With Human Papillomavirus Infection

2006 ◽  
Vol 54 (12) ◽  
pp. 1393-1399 ◽  
Author(s):  
Benibelks Albarran-Somoza ◽  
Ramon Franco-Topete ◽  
Vidal Delgado-Rizo ◽  
Felipe Cerda-Camacho ◽  
Lourdes Acosta-Jimenez ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Precursor Lesions ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection

scholarly journals Human papillomavirus infection and cervical cancer precursor lesions in women living by Amazon rivers: investigation of relations with markers of oxidative stress

2018 ◽  
Vol 16 (3) ◽  
Author(s):  
Bruna Emanuelle Sanches Borges ◽  
Elza Baia de Brito ◽  
Hellen Thais Fuzii ◽  
Cláudia Simone Baltazar ◽  
Aline Barreto Sá ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Low Grade ◽  
Oxidized Glutathione ◽  
Precursor Lesions ◽  
Total Glutathione ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Significant Difference

ABSTRACT Objective To investigate the relation between oxidative stress markers, human papillomavirus infection and cervical cancer precursor lesions. Methods The study comprised women aged 14 to 60 years living in communities located by Amazon rivers in the state of Pará (Itaituba, Limoeiro do Ajuru and Bragança, 126, 68 and 43 women respectively). Papanicolau smears and polymerase chain reaction tests for human papillomavirus DNA detection were performed. Blood samples were collected to test malondialdehyde, total and oxidized glutathione levels. Results Malondialdehyde, total and oxidized glutathione concentrations did not differ significantly (p>0.05) between women with and without low-grade squamous intraepithelial lesions across communities. Malondialdehyde levels (8.02nmols/mL) were almost five times higher in human papillomavirus-positive compared to human papillomavirus-negative women (1.70nmols/mL) living in Itaituba (statistically significant difference; p<0.05). Malondialdehyde levels did not differ significantly (p>0.05) between human papillomavirus-positive and human papillomavirus-negative women living in remaining communities. Significant (p<0.05) differences in total glutathione levels between human papillomavirus-positive and human papillomavirus-negative women (8.20μg/mL and 1.47μg/mL, respectively) were limited to those living in Bragança. Conclusion Malondialdehyde and total glutathione levels were significantly associated with human papillomavirus infection. However, lack of similar associations with squamous lesions suggest oxidative stress alone does not explain correlations with cervical carcinogenesis. Other factors may therefore be involved.

FOXP3 immunoregulatory gene variants are independent predictors of human papillomavirus infection and cervical cancer precursor lesions

2019 ◽  
Vol 145 (8) ◽  
pp. 2013-2025 ◽  
Author(s):  
Fernando Cezar-dos-Santos ◽  
Rodolfo Sanches Ferreira ◽  
Nádia Calvo Martins Okuyama ◽  
Kleber Paiva Trugilo ◽  
Michelle Mota Sena ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Gene Variants ◽  
Precursor Lesions ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection

Human Papillomavirus Infection of the Cervix

2021 ◽  
pp. 170-174
Author(s):  
Jacqueline M. Mills ◽  
Elizabeth A. Stier
Keyword(s):  
Cervical Cancer ◽  
At Risk ◽  
Human Papillomavirus ◽  
Hpv Vaccine ◽  
Cervical Neoplasia ◽  
Hpv 16 ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Hpv Genotypes ◽  
Prophylactic Hpv Vaccine

In 1992 Lorincz et al. were the first to evaluate the clinicopathologic correlation with 11 recently identified human papillomavirus (HPV) genotypes: 31, 33, 35, 42, 43, 44, 45, 51, 52, 56, and 58. Using cervical samples from 8 studies that included specimens from 2627 women, HPV genotypes were categorized by the likelihood of association with grades of cervical neoplasia (from normal to cancer). These findings were the basis of the determination that (a) HPV causes cervical cancer, (b) detection of the cancer associated HPV genotypes could identify women at risk for cervical pre-cancer and cancer, and (c) a prophylactic HPV vaccine should include protection against (at least) HPV 16 and 18.

Sign in / Sign up

Export Citation Format

Share Document