Rapid Evolution of Virulence and Drug Resistance in the Emerging Zoonotic Pathogen Streptococcus suis

Streptococcus suis is a zoonotic pathogen with worldwide distribution, responsible for more than 700 human cases globally reported. This infection affects mostly men, exposed to pig or pork, which leads to its usual classification as an occupational disease. We report a case of acute bacterial meningitis in a 44 years old male. According to his past medical history, the patient had alcohol consumption and worked in a restaurant as a piglet griller. Microbiological examination of blood and CSF revealed S. suis. After 14 days of ceftriaxone the patient fully recovered. The authors review the clinical reports previously described in Portugal. In all of them was possible to identify risk exposition to pork. We alert to this microorganism’s importance in Portugal where it is probably underdiagnosed.<br /><strong>Keywords:</strong> Occupational Diseases; Occupational Exposure; Meningitis, Bacterial; Streptococcal Infections; Streptococcus suis; Portugal.

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Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand

Pathogens ◽

10.3390/pathogens9010050 ◽

2020 ◽

Vol 9 (1) ◽

pp. 50 ◽

Cited By ~ 3

Author(s):

Anusak Kerdsin ◽

Dan Takeuchi ◽

Aniroot Nuangmek ◽

Yukihiro Akeda ◽

Marcelo Gottschalk ◽

...

Keyword(s):

Risk Factor ◽

Risk Group ◽

Streptococcus Suis ◽

Prevalence Rates ◽

Swine Industry ◽

Carriage Rate ◽

Zoonotic Pathogen ◽

Pork Products ◽

Economic Significance ◽

Sequence Types

Streptococcus suis is a zoonotic pathogen of economic significance to the swine industry. The number of infected cases is increasing in humans worldwide. In this study, we determined the prevalence and diversity of S. suis carriage in slaughterhouse pigs in Phayao province, Thailand, where an outbreak occurred in 2007. The overall S. suis carriage rate was 35.2% among slaughterhouse pigs. The prevalence rates of serotypes 2 and 14 (the major serotypes infected in humans) were 6.7% and 2.6%, respectively. In both serotypes, 70.4% of isolates of serotypes 2 and 14 revealed sequence types and pulsotypes identical to human isolates in Thailand. It is suggested that pathogenic strains of S. suis are a risk factor for occupational exposure to pigs or the consumption of raw pork products. Food safety, hygiene, and health education should be encouraged to reduce the risk group.

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Treating symptomatic infections and the co-evolution of virulence and drug resistance

10.24072/pcjournal.38 ◽

2021 ◽

Vol 1 ◽

pp. 1-None

Author(s):

Samuel Alizon

Keyword(s):

Drug Resistance ◽

Evolution Of Virulence

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ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE Xestospongia sp.

Indonesian Journal of Chemistry ◽

10.22146/ijc.21276 ◽

2013 ◽

Vol 13 (3) ◽

pp. 199-204 ◽

Cited By ~ 3

Author(s):

Murtihapsari Murtihapsari ◽

Apriani Sulu Parubak ◽

Bertha Mangallo ◽

Wiwied Ekasari ◽

Puji Budi Asih ◽

...

Keyword(s):

Drug Resistance ◽

Plasmodium Falciparum ◽

Secondary Metabolites ◽

Marine Sponge ◽

Spectrum Analysis ◽

Extraction Method ◽

Rapid Evolution ◽

Hexane Extraction ◽

Marine Life ◽

Plausible Structure

Plasmodium falciparum, the agent of malignant malaria, is one of mankind's most severe scourges, mainly in the tropic world. Efforts to develop preventive vaccines or remedial drugs are handicapped by the parasite's rapid evolution of drug resistance. Here, we presented an advance work on examination of antimalarial component from marine life of Xestospongia sp., the study is based on hexane extraction method. The premier result, we obtained five fractions. Among these five fractions, the fourth has the most potent inhibitory against the growth of P. falciparum 3D7 with an IC50: 7.13 µg/mL. A compiled spectrum analysis, FTIR, 1H-NMR and GC-MS, revealed that the fourth fraction consisted abundantly of two secondary metabolites such as flavonoids and triterpenoids. Finally, our results suggest a plausible structure rooted to the base of ibuprofen.

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