scholarly journals SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals

PLoS ONE ◽  
2010 ◽  
Vol 5 (7) ◽  
pp. e11755 ◽  
Author(s):  
Sayaka Akieda-Asai ◽  
Nobuhiro Zaima ◽  
Koji Ikegami ◽  
Tomoaki Kahyo ◽  
Ikuko Yao ◽  
...  
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Hormone Release ◽  
Lysine Residues ◽  
Stimulating Hormone

Inappropriate thyroid-stimulating hormone release in the elderly?

1985 ◽  
Vol 15 (2) ◽  
Author(s):  
Antonio E. Pontiroli ◽  
Miriam Alberetto ◽  
Guido Pozza
Keyword(s):  
The Elderly ◽  
Thyroid Stimulating Hormone ◽  
Hormone Release ◽  
Stimulating Hormone

scholarly journals Immunochemical characterization of two thyroid-stimulating hormone β-subunit epitopes

1995 ◽  
Vol 308 (1) ◽  
pp. 203-210 ◽  
Author(s):  
W D Fairlie ◽  
P G Stanton ◽  
M T W Hearn
Keyword(s):  
Receptor Binding ◽  
Binding Sites ◽  
Thyroid Stimulating Hormone ◽  
Beta Subunit ◽  
Human Thyroid ◽  
Lysine Residues ◽  
Sequence Region ◽  
The Relationship ◽  
Stimulating Hormone

The epitopes of human thyroid-stimulating hormone (hTSH) recognized by two murine monoclonal antibodies (MAbs), designated MAb 279 and MAb 299, have been characterized. These MAbs are highly specific for the beta-subunit of TSH. The epitope recognized by MAb 279 appears to be completely conserved between bovine and human TSH and partially conserved in the porcine species. The TSH beta-subunit epitope recognized by MAb 299 is only partially conserved between the human, bovine and porcine species. Both MAbs are capable of inhibiting the binding of TSH to its receptor in a TSH radioreceptor assay, indicating that the epitopes either coincide or are located close to the TSH beta-subunit receptor-binding sites. The carbohydrate moieties of the TSH beta-subunit appear to play little or no role in the epitope recognition by MAb 279 or MAb 299 while the integrity of the disulphide bonds are essential. The epitopic recognition may also involve lysine residues, as determined by the immunoreactivity with both MAbs following citraconylation of TSH. In addition, the amino acid sequence region between residues bTSH beta 34-44 could be excised by trypsin digestion of bovine TSH beta (bTSH beta) without eliminating epitopic recognition by either MAb. These results provide further insight into the relationship between the structure of the TSH beta-subunit epitopes and location of the receptor-binding sites.

Thyroid Stimulating Hormone and Growth Hormone Responses to Thyrotropin Releasing Hormone in Anorexia Nervosa

1981 ◽  
Vol 10 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Mark S. Gold ◽  
A. L. C. Pottash ◽  
David M. Martin ◽  
Lawrence B. Finn ◽  
Robert K. Davies
Keyword(s):  
Growth Hormone ◽  
Anorexia Nervosa ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Hormone Response ◽  
Releasing Hormone ◽  
Hormone Responses ◽  
Stimulating Hormone

Ten female patients who satisfied objective criteria for the diagnosis of anorexia nervosa were given 500 ug of thyrotropin releasing hormone. Thyroid stimulating hormone and growth hormone responses were measured in duplicate by radioimmunoassay. These patients had a low normal Δ thyroid stimulating hormone but a delayed peak response. In addition, these patients had pathological growth hormone release in response to thyrotropin releasing hormone infusion. Both delayed peak thyroid stimulating hormone and growth hormone response to thyrotropin releasing hormone have been reported for patients with hypothalamic disorders.

scholarly journals Thyroid-Stimulating Hormone Stimulation Tests in the Bottlenose Dolphin (Tursiops truncatus)

2021 ◽  
Vol 2 (2) ◽  
pp. 265-272
Author(s):  
Dorian S. Houser ◽  
Cory Champagne ◽  
Daniel E. Crocker
Keyword(s):  
Tursiops Truncatus ◽  
Bottlenose Dolphins ◽  
Thyroid Stimulating Hormone ◽  
Hormone Release ◽  
Total Triiodothyronine ◽  
Stimulation Tests ◽  
Total Thyroxine ◽  
Recombinant Tsh ◽  
Tsh Stimulation ◽  
Stimulating Hormone

Stimulation of the thyroid with thyroid-stimulating hormone (TSH) is a potentially useful diagnostic of thyroid dysfunction, but little is known about the response of the thyroid to TSH stimulation in bottlenose dolphins (Tursiops truncatus). To better characterize the response of the dolphin thyroid to TSH stimulation, five adult dolphins participated in a TSH stimulation study. Dolphins voluntarily beached onto a padded mat and were given a 1.5 mg intramuscular injection of human recombinant TSH. Blood samples collected the day prior, at multiple intervals the day of, and daily for three days after the injection were analyzed via radioimmunoassay for free and total triiodothyronine (fT3 and tT3), and free and total thyroxine (fT4 and tT4). Significant increases in circulating fT3, fT4, and tT4 were observed with peaks occurring for all hormones the day after the TSH injection; maximal increases were 44%, 47%, and 23% for each hormone, respectively. Temporal patterns in the hormones potentially reflected feedback mechanisms countering the surge in fT3 following stimulation. Though recombinant human TSH was effective at stimulating hormone release, it is likely that use of dolphin or dolphin-derived TSH would enhance the clinical utility of the stimulation test, as would the development of antibodies specific to dolphin TSH.

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