scholarly journals Guinea Pig Model for Evaluating the Potential Public Health Risk of Swine and Avian Influenza Viruses

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e15537 ◽  
Author(s):  
Yipeng Sun ◽  
Yuhai Bi ◽  
Juan Pu ◽  
Yanxin Hu ◽  
Jingjing Wang ◽  
...  
2005 ◽  
Vol 49 (3) ◽  
pp. 317-327 ◽  
Author(s):  
Michael L. Perdue ◽  
David E. Swayne

2013 ◽  
Vol 175 (2) ◽  
pp. 151-154 ◽  
Author(s):  
Maria Stincarelli ◽  
Rosaria Arvia ◽  
Maria Alessandra De Marco ◽  
Valeria Clausi ◽  
Fabiana Corcioli ◽  
...  

2018 ◽  
Vol 93 (4) ◽  
Author(s):  
Yasuha Arai ◽  
Madiha S. Ibrahim ◽  
Emad M. Elgendy ◽  
Tomo Daidoji ◽  
Takao Ono ◽  
...  

ABSTRACT The cocirculation of H5N1 and H9N2 avian influenza viruses in birds in Egypt provides reassortment opportunities between these two viruses. However, little is known about the emergence potential of reassortants derived from Egyptian H5N1 and H9N2 viruses and about the biological properties of such reassortants. To evaluate the potential public health risk of reassortants of these viruses, we used reverse genetics to generate the 63 possible reassortants derived from contemporary Egyptian H5N1 and H9N2 viruses, containing the H5N1 surface gene segments and combinations of the H5N1 and H9N2 internal gene segments, and analyzed their genetic compatibility, replication ability, and virulence in mice. Genes in the reassortants showed remarkably high compatibility. The replication of most reassortants was higher than the parental H5N1 virus in human cells. Six reassortants were thought to emerge in birds under neutral or positive selective pressure, and four of them had higher pathogenicity in vivo than the parental H5N1 and H9N2 viruses. Our results indicated that H5N1-H9N2 reassortants could be transmitted efficiently to mammals with significant public health risk if they emerge in Egypt, although the viruses might not emerge frequently in birds. IMPORTANCE Close interaction between avian influenza (AI) viruses and humans in Egypt appears to have resulted in many of the worldwide cases of human infections by both H5N1 and H9N2 AI viruses. Egypt is regarded as a hot spot of AI virus evolution. Although no natural reassortant of H5N1 and H9N2 AI viruses has been reported so far, their cocirculation in Egypt may allow emergence of reassortants that may present a significant public health risk. Using reverse genetics, we report here the first comprehensive data showing that H5N1-N9N2 reassortants have fairly high genetic compatibility and possibly higher pathogenicity in mammals, including humans, than the parental viruses. Our results provide insight into the emergence potential of avian H5N1-H9N2 reassortants that may pose a high public health risk.


PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12591 ◽  
Author(s):  
Yanlong Cong ◽  
Guangmei Wang ◽  
Zhenhong Guan ◽  
Shuang Chang ◽  
Quanpeng Zhang ◽  
...  

2006 ◽  
Vol 11 (15) ◽  
Author(s):  
Collective Influenza team (ECDC)

The natural reservoir of influenza viruses is generally considered to be wild waterbirds. In this animal group, many species of influenza viruses circulate without seeming to cause much disease, and are therefore known as ‘low pathogenic’ avian influenza viruses


2020 ◽  
Vol 3 (3) ◽  
pp. 58-61
Author(s):  
Shadrach Okhuebor ◽  
Osazee Izevbuwa

Suya originated in the northern parts of Nigeria is ready to eat grilled skewered meat products prepared in different forms spiced with locally sourced, commonly produced by the Hausas in Northern Nigeria. It has permeated Nigerian society, being affordable for all and available everywhere. It is produced from boneless meat hung on stick and spiced with peanut cake, salt, vegetable oil and other flavourings followed by roasting around a glowing charcoal fire. It’s generally made with skewered beef, ram, or chicken. Innards such as kidney, liver, and tripe are also used. Suya are of three main forms namely Tsire, Kilishi, and Balangu, and Tsire is the most commonly preferred. In Benin City, which is located in the southern part of Nigeria, Suya has become a very common street food delicacy scattered most major areas and are sold mostly in the evening time, only very few vendors will sell Suya in the day time. Concerns have been raised in many research regarding the public health risk of consuming suya, part of which is food poisoning, as a result microbial contamination such as Bacillus cereus, Staphylococcus aureus, aflatoxigenic molds,  Staphylococcus epidermidis, Proteus vulgaris, Klebseilla pneumoniae, Escherichia coli, Candida spp., Salmonella enteritica and Enterobacter spp. Trace metals such as zinc, lead, manganese, iron, and copper have been observed in suya in concentrations exceeding recommended tolerable upper intake levels which can consequently cause serious long term health issues. This study reviews the potential public health risk of consuming street grilled meat (Suya) in Benin City.


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