scholarly journals Antitumor Effect of Malaria Parasite Infection in a Murine Lewis Lung Cancer Model through Induction of Innate and Adaptive Immunity

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e24407 ◽  
Author(s):  
Lili Chen ◽  
Zhengxiang He ◽  
Li Qin ◽  
Qinyan Li ◽  
Xibao Shi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Malaria Parasite ◽  
Antitumor Effect ◽  
Parasite Infection ◽  
Lewis Lung ◽  
Cancer Model ◽  
Lewis Lung Cancer ◽  
Innate And Adaptive Immunity ◽  
Malaria Parasite Infection ◽  
Lung Cancer Model

scholarly journals Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Zhuo Chen ◽  
Xiang Qian ◽  
Shasha Chen ◽  
Xiaoxuan Fu ◽  
Guanjun Ma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Therapeutic Efficacy ◽  
Combined Treatment ◽  
Receptor Interaction ◽  
Lewis Lung ◽  
Cancer Model ◽  
Lewis Lung Cancer ◽  
Antitumor Effects ◽  
Akkermansia Muciniphila ◽  
Lung Cancer Model

Recently, intestinal flora plays a vital role in the occurrence and development of tumors and there is link between cancer immunotherapy and Akkermansia muciniphila (Akk). However, the therapeutic efficacy of Akk in lung cancer remained unclear. Hence, our study is aimed at investigating the antitumor effects of cisplatin (CDDP) combined with Akk on lung cancer. Using the murine lung cancer model by subcutaneously inoculating Lewis lung cancer model, 50 mice were divided into five groups: normal, model, CDDP, CDDP+Akk, and CDDP+antibiotics. After treatment within 5 weeks, compared with the model group, the administered group improved the changes of tumor pathomorphology. Compared with the CDDP group, CDDP combining with Akk slowed down the growth of tumor volume, downregulated the levels of ki-67, p53, and factor-associated suicide (Fas) ligand proteins and upregulated Fas proteins, increased the levels of interferon-γ, interleukin-6, and tumor necrosis factor-α, and suppressed the expression of CD4+CD25+Foxp3+ Treg in mouse peripheral blood and spleen. In addition, transcriptome analysis indicated that Akk combining with CDDP increased obviously the levels of IFI27l2 and IGFBP7 and was related to those pathways including the cytokine-cytokine receptor interaction, Th17 cell differentiation, FOXO, JAK-STAT, and PI3K-Akt signaling pathways. These results suggested that the therapeutic efficacy of the combined treatment of Akk and CDDP was superior to the only CDDP treatment, which could enhance immune regulation and would be a promising strategy for the treatment of lung cancer.

scholarly journals Exosomes from Plasmodium-infected hosts inhibit tumor angiogenesis in a murine Lewis lung cancer model

Oncogenesis ◽  
2017 ◽  
Vol 6 (6) ◽  
pp. e351-e351 ◽  
Author(s):  
Y Yang ◽  
Q Liu ◽  
J Lu ◽  
D Adah ◽  
S Yu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Angiogenesis ◽  
Lewis Lung ◽  
Cancer Model ◽  
Lewis Lung Cancer ◽  
Lung Cancer Model

scholarly journals Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM

2011 ◽  
Vol 8 (4) ◽  
pp. 359-367 ◽  
Author(s):  
Yuchan Cai ◽  
Shudao Xiong ◽  
Yijie Zheng ◽  
Feifei Luo ◽  
Pei Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Immune Response ◽  
Lewis Lung ◽  
Cancer Model ◽  
Lewis Lung Cancer ◽  
Lung Cancer Model

Sustained delivery of endostatin improves the efficacy of therapy in Lewis lung cancer model

2009 ◽  
Vol 134 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Jinhui Wu ◽  
Dawei Ding ◽  
Guoyan Ren ◽  
Xiangyang Xu ◽  
Xiaojin Yin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Sustained Delivery ◽  
Lewis Lung ◽  
Cancer Model ◽  
Lewis Lung Cancer ◽  
Lung Cancer Model

Abstract 6648: Racotumomab and PD-1 blockade combination exhibits an additive antitumor effect in a non-small cell lung cancer model

2020 ◽  
Author(s):  
Valeria I. Segatori ◽  
Cynthia A. Gulino ◽  
Carla S. Capobianco ◽  
Selene Rojo ◽  
Gretel M. Ferreira ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Antitumor Effect ◽  
Small Cell ◽  
Cancer Model ◽  
Small Cell Lung ◽  
Lung Cancer Model
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