Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research

Mutations in MeCP2 result in a crippling neurological disease, but we lack a lucid picture of MeCP2s molecular role. Focusing on individual transcriptomic studies yields inconsistent differentially expressed genes. We have aggregated and homogeneously processed modern public MeCP2 transcriptome data, which we present in a web portal. With this big data, we discovered a commonly perturbed core set of genes that transcends the limitations of any individual study. We then found distinct consistently up and downregulated subsets within these genes. We observe enrichment for this mouse core in other species MeCP2 models and see overlap between this core and ASD models. Analysis of signal to noise finds that many studies lack enough biological replicates. By integrating and examining transcriptomic data at scale, we have generated a valuable resource and insight on MeCP2 function.

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Mapping Open Access Publishing Trends in Bangladesh: A Study with Reference to Open Access Journals and Repositories

Asian Journal of Information Science and Technology ◽

10.51983/ajist-2019.9.3.296 ◽

2019 ◽

Vol 9 (3) ◽

pp. 1-7

Author(s):

Rajesh Kumar Das

Keyword(s):

Higher Education ◽

Open Access ◽

Diarrhoeal Disease ◽

Open Access Publishing ◽

Policy Rules ◽

Disease Research ◽

Mass Consciousness ◽

Open Access Journals ◽

Present Trend ◽

Data Content

Open Access initiative in Bangladesh dates back to the opening of icddr, b Journal of Diarrhoeal Disease Research (JDDR) in 1997 by International Centre for Diarrhoeal Disease Research, Bangladesh. Since then considerable development of Open Access has occurred. The study also provided some recommendations for improvement of IR and open movement in Bangladesh. The paper analyzes current open access publishing trends in Bangladesh in the light of open access journals and repositories in Bangladesh. The data for the study were collected from BanglaJOL and OpenDOAR (Directory of Open Access Repositories) in August 2017.Thefindings of the study indicate that the trends towards the development of open access repositories are increasing among higher education and research institutions in Bangladesh. Through BanglaJOL nearly 97% of journals in Bangladesh are published open access. There are total 11 IR found in OpenDOAR and ROAR in Bangladesh. It is found in this study that among 11 repositories 8 repositories have specified policy rules with regards to metadata, data, content, submission, and preservation. But the scenario is different in terms of OAI-PMH compliance. Presently only 3 repositories are following the OAI-PMH protocols in Bangladesh. Moreover, this trend should be increased to a larger proportion and all toll-access publishing would be turned open in Bangladesh through mass consciousness and initiatives at broader level. This study recommends that present trend should be increased to a larger proportion and all toll-access publishing would be turned open in Bangladesh through mass consciousness and initiatives at broader level.

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