DNA methylation aging and transcriptomic studies in horses

Cytosine methylation patterns have not yet been thoroughly studied in horses. Here, we profile n = 333 samples from 42 horse tissue types at loci that are highly conserved between mammalian species using a custom array (HorvathMammalMethylChip40). Using the blood and liver tissues from horses, we develop five epigenetic aging clocks: a multi-tissue clock, a blood clock, a liver clock and two dual-species clocks that apply to both horses and humans. In addition, using blood methylation data from three additional equid species (plains zebra, Grevy’s zebras and Somali asses), we develop another clock that applies across all equid species. Castration does not significantly impact the epigenetic aging rate of blood or liver samples from horses. Methylation and RNA data from the same tissues define the relationship between methylation and RNA expression across horse tissues. We expect that the multi-tissue atlas will become a valuable resource.

Telesimulation and Academic Continuity of Health Professions Education

Telesimulation, specifically in health areas, is an educational technique that combines clinical simulation and communication technologies. This definition has been constantly modified, but today more than ever it represents a valuable resource to provide academic continuity. The purpose of this chapter is to present the basic concepts of this strategy while reviewing its antecedents/history in the pre-COVID era, the experience with this technique in health sciences, as well as the processes and resources essential to carry it out with an analysis of the potential limitations that may entail. Likewise, concrete examples of telesimulation in various subjects will be shared, leaving readers the challenge of constant innovation in this field.

A case of idiopathic nephrotic syndrome treated with the homeopathic therapeutic

Nephrotic syndrome is a chronic clinical condition and drugs used in its treatment may result in severe side-effects. Renal transplantation or renal ablation and subsequent chronic dialysis treatment may be the only feasible way to patients. The present article reports the case of a 23-years-old white woman that presented nephrotic syndrome and was successfully treated with homeopathic medicines. Six kind of homeopathic diagnoses were made to build the clinical homeopathic picture of the patient and to determine the appropriate medicines, according to the clinical protocol used. Apis mellifica was the main medicine used to treat the diathesis sycosis. The satisfactory treatment outcome shows that the judicious homeopathic therapeutic may be a valuable resource in the treatment of nephrotic syndrome. Keywords: Nephrotic syndrome; Clinical protocol; Diathesis; Sycosis; Homeopathy  Um caso de síndrome nefrótica idiopática tratada com terapéutica homeopática. Resumo A síndrome nefrótica é uma condição clínica crônica. Os fármacos utilizados em seu tratamento podem produzir severos efeitos colaterais. O transplante ou a ablação renal, com a necessidade posterior de diálise, as vezes é a única alternativa real de tratamento. Este artigo descreve o caso de um paciente de 23 anos de idade portador de síndrome nefrótica. Foram realizados 6 diagnósticos homeopáticos para construir um quadro clínico homeopático do paciente e determinar os medicamentos homeopáticos, bem como o protocolo terapéutico. Apis mellifica foi o principal medicamento utilizado para tratar a diástesis sicótica. Os resultados terapéuticos foram satisfatórios e indicam que uma terapéutica homeopática racional pode ser um valioso recurso no tratamento da síndrome nefrótica. Palavras-chave: Síndrome nefrótica; Protocolo clínico; Diatese; Sicose; Homeopatia.  Un caso de síndrome nefrotico idiopatico tratado con terapeutica homeopatica Resumen El síndrome nefrótico es una condición clínica crónica; los fármacos utilizados en su tratamiento pueden producir severos efectos colaterales. El trasplante o ablación renal, con la necesidad posterior de diálisis, a veces es la única alternativa real de tratamiento. Este artículo describe el caso de una paciente de 23 años de edad portadora de síndrome nefrótico; 6 diagnósticos homeopáticos fueron realizados para construir el cuadro clínico homeopático de la paciente y determinar los medicamentos homeopáticos, como prescripto por el protocolo terapéutico utilizado. Apis mellifica fue el principal medicamento utilizado para tratar la diátesis sicótica. Los resultados terapéuticos favorables muestran que una terapéutica homeopática racional puede ser un recurso valioso en el tratamiento del síndrome nefrótico. Palabras-clave: Síndrome nefrótico; Protocolo clínico; Diatese; Sicose; Homeopatia  Correspondence author: Luiz Figueira Pinto, [email protected] How to cite this article: Pinto LF. A case of idiopathic nephrotic syndrome treated with the homeopathic therapeutic. Int J High Dilution Res [online]. 2009 [cited YYYY Mmm dd]; 8(26):26-32. Available from: http://journal.giri-society.org/index.php/ijhdr/article/view/302/382. ÂÂÂ

CONCEPTUAL PRINCIPLES OF LEARNING ORGANIZATION

The main purpose of this study is to present conceptual principles of the learning organisation as a modern form of functioning of contemporary organisations and enterprises and the awareness of the dominant role of intangible resources. The most important factor that protects organizations from solidifying is knowledge. In an organization, knowledge is produced by people and these people learn. However, learning alone is not sufficient for the success of the organization. For a lasting and sustainable process, organizational learning is required. Knowledge, on the other hand, is inextricably linked to human capital, which is now the most valuable resource of the new forms of organisation.

Taking risks the safe way: risk management and insurance practices of Ontario's Voluntary Sector

Taking Risks the Safe Way was developed as a knowledge‐building tool and research reference for nonprofit organizations across Ontario. The contents of this document will also guide the work of government in supporting capacity‐building among voluntary and community organizations, and provide a valuable resource for the insurance industry in serving the nonprofit sector. Keywords: CVSS, Centre for Voluntary Sector Studies, Working Paper Series,TRSM, Ted Rogers School of Management Citation

Taking risks the safe way: risk management and insurance practices of Ontario's Voluntary Sector

Taking Risks the Safe Way was developed as a knowledge‐building tool and research reference for nonprofit organizations across Ontario. The contents of this document will also guide the work of government in supporting capacity‐building among voluntary and community organizations, and provide a valuable resource for the insurance industry in serving the nonprofit sector. Keywords: CVSS, Centre for Voluntary Sector Studies, Working Paper Series,TRSM, Ted Rogers School of Management Citation

The genome sequence of the lesser marbled fritillary, Brenthis ino, and evidence for a segregating neo-Z chromosome

The lesser marbled fritillary, Brenthis ino (Rottemburg, 1775), is a species of Palearctic butterfly. Male B. ino individuals have been reported to have between 12 and 14 pairs of chromosomes, a much reduced chromosome number than is typical in butterflies. Here we present a chromosome-level genome assembly for B. ino, as well as gene and transposable element annotations. The assembly is 411.8 Mb in span with contig and scaffold N50s of 9.6 and 29.5 Mb respectively. We also show evidence that the male individual from which we generated HiC data was heterozygous for a neo-Z chromosome, consistent with inheriting 14 chromosomes from one parent and 13 from the other. This genome assembly will be a valuable resource for studying chromosome evolution in Lepidoptera, as well as for comparative and population genomics more generally.

A Preference for Peers over Faculty in the Pandemic Era: Development and Evaluation of a Medical Student-led Virtual Physiology Exam Review

In the middle of the COVID-19 pandemic, students at the University of California, Irvine, reimagined their peer-led, small-group, tutorial sessions into an online format. The virtual sessions improved student-reported understanding of physiological principles and reduced exam anxiety. Peer-led review remains a valuable resource in the era of virtual medical education.

Understanding and Explaining How Staff Promote Quality for Older People Living in Long-Term Care Facilities

Little is known about how the workforce influences quality in long term care facilities for older people. Conceptually, quality is complex, often contested, and dynamic, has overlapping physical, social, psychological and emotional dimensions and can refer to both quality of life and quality of care. Assuming ‘more staff equates to better quality’ is intuitively appealing but research suggests that a more nuanced, non-linear, relationship exists. A programme of research in the UK is developing theoretical and empirical explanations of how staff promote quality for older people living in long-term care facilities. It shifts the debate from numbers of staff and their relationship to quality indicators toward recognising the ways in which staff more broadly influence quality. Our work will be useful for people and organisations making policy and delivering services on the best ways to deploy and support quality in long term care through the most valuable resource: its staff.

“What kind of cop are you?”: Disco Elysium’s Technologies of the Self within the Posthuman Multiverse

I suggest in this article, drawing upon Francesca Ferrando, Karen Barad and N Katherine Hayles, that Disco Elysium illustrates the human through the mode of a ‘posthuman multiverse’. Per Ferrando, humans and other beings act as nodes in a material multiverse while what we think, eat, our behaviours and relations, create part of a rhizomatic ecology that can be understood as who and what we are. This, I illustrate, overcomes a complicated tension in existing posthuman theory, particularly as it relates to game studies. Although theorists have detailed the entanglement of players and machines, and the new materialist nature of becoming, it is unclear to what extent human-machine assemblages can be said to be a singular ‘thing’. This is tackled in Disco Elysium as the seemingly mundane and often invisible actions the player takes, all play a role in constructing Harry Dubois and the world that is also endlessly producing him. Game actions, therefore, can be viewed as ‘technologies of the multiverse’, the ontological functions through which beings come to exist in a dimension. The game positions the player in a ‘relational intra-activity’ not only with the actions and outcomes of play, as discussed in previous scholarship, but also with the hypothetical outcomes of choices they have not made. When read through the lens of Ferrando’s philosophical posthuman multiverse, Disco Elysium represents a valuable resource for bridging gaps in contemporary posthuman scholarship.