scholarly journals Platelet-to-Lymphocyte Ratio: A Novel Marker for Critical Limb Ischemia in Peripheral Arterial Occlusive Disease Patients

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e67688 ◽  
Author(s):  
Thomas Gary ◽  
Martin Pichler ◽  
Klara Belaj ◽  
Franz Hafner ◽  
Armin Gerger ◽  
...  
Keyword(s):  
Critical Limb Ischemia ◽  
Peripheral Arterial Occlusive Disease ◽  
Limb Ischemia ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Peripheral Arterial

scholarly journals Gender-related differences in critical limb ischemia due to peripheral arterial occlusive disease

2013 ◽  
Vol 12 (4) ◽  
pp. 278-283 ◽  
Author(s):  
Vanessa Prado dos Santos ◽  
Carlos Alberto Silveira Alves ◽  
Cicero Fidelis Lopes ◽  
Jose Siqueira de Araujo Filho
Keyword(s):  
Risk Factors ◽  
Critical Limb Ischemia ◽  
Peripheral Arterial Occlusive Disease ◽  
Clinical Characteristics ◽  
Limb Ischemia ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Male And Female ◽  
Female Patients ◽  
Peripheral Arterial

BACKGROUND: Mortality from cardiovascular disease has declined among men and increased among North American women. Recent studies have revealed differences between genders in the epidemiology of atherosclerotic disease. OBJECTIVE: To study possible differences between male and female patients with critical limb ischemia (CLI) according to risk factors of atherosclerosis and clinical characteristics of lower limbs with peripheral arterial occlusive disease (PAOD). METHODS: The study included 171 male and female patients treated for CLI due to infrainguinal PAOD and compared clinical characteristics (Rutherford category and PAOD territory), risk factors for atherosclerosis (diabetes, age, smoking and hypertension) and number of opacified arteries on digital angiograms of the leg. The EPI-INFO software was used for statistical analysis, and the level of significance was set at p<0.05. RESULTS: Mean age was 70 years, and 88 patients were men (52%). For most patients (both genders), Rutherford category was 5 (82 % of men and 70% of women; p=0.16). The group of women had higher mean age (73 vs. 67 years; p=0.0002) and greater prevalence of diabetes (66% vs. 45%; p=0.003) and hypertension (90% vs. 56%; p=0.0000001). Among men, the prevalence of smoking was higher (76% vs. 53%; p=0.0008). The analysis of digital angiograms revealed that opacification of only one artery in the leg was found for 74% of women (vs. 50% of men). CONCLUSION: The prevalence of risk factors for atherosclerosis and the characteristics of PAOD are different between male and female patients with CLI.

scholarly journals Demographic and Comorbidity Pattern of Patients with Critical Limb Ischemia

Folia Medica ◽  
2017 ◽  
Vol 59 (1) ◽  
pp. 14-22 ◽  
Author(s):  
Răzvan A. Ciocan ◽  
Sorana D. Bolboacă ◽  
Şerban Rădulescu ◽  
Bogdan Stancu ◽  
Andra Ciocan ◽  
...  
Keyword(s):  
Secondary Education ◽  
Critical Limb Ischemia ◽  
Peripheral Arterial Occlusive Disease ◽  
Limb Ischemia ◽  
High Serum ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Male Smoker ◽  
Arterial Blood ◽  
Peripheral Arterial

Abstract Aim: The present study aimed at identifying the pattern of patients with critical limb ischemia (CLI) compared with those with peripheral arterial occlusive disease (PAOD). Materials and methods: A four-year retrospective study was conducted with patients hospitalized in the Second Surgical Clinic at the Emergency County Hospital Cluj-Napoca. The medical charts of patients with PAOD (n=466) and CLI (n=223) were reviewed and data were collected. Results: The study included 689 patients; mean age 67 years for PAOD patients and 65 years for CLI patients. A significantly higher percentage of patients were male in both groups (79.25%, P < 0.0001). Most of the patients in both groups had received at least a secondary education (P < 0.0001). Most of the subjects in both groups were smokers (>71.30%) with no difference between groups (P = 0.566). No significant differences were found between the groups in comorbidities (diabetes, arterial blood hypertension, cardiac ischemia, rhythm disorders, P > 0.05). There were more CLI patients that were overweight than overweight patients with PAOD (P = 0.0004). High serum cholesterol (>200 mg/dL) and triglycerides (>150 mg/dL) levels were found in the CLI group (P < 0.05). Age was identified as a risk factors for amputation (OR = 1.03, 95%Cl [1.01−1.05], P = 0.0012). Conclusions: The profile of a patient with critical limb ischemia and peripheral arterial occlusive disease is a 65-67-year-old male smoker with at least a secondary education. The CLI patient is overweight with pathological serum levels of cholesterol and triglycerides.

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