scholarly journals Chronic Clomipramine Treatment Reverses Core Symptom of Depression in Subordinate Tree Shrews

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e80980 ◽  
Author(s):  
Jing Wang ◽  
Anping Chai ◽  
Qixin Zhou ◽  
Longbao Lv ◽  
Liping Wang ◽  
...  
Author(s):  
J. P. Brunschwig ◽  
R. M. McCombs ◽  
R. Mirkovic ◽  
M. Benyesh-Melnick

A new virus, established as a member of the herpesvirus group by electron microscopy, was isolated from spontaneously degenerating cell cultures derived from the kidneys and lungs of two normal tree shrews. The virus was found to replicate best in cells derived from the homologous species. The cells used were a tree shrew cell line, T-23, which was derived from a spontaneous soft tissue sarcoma. The virus did not multiply or did so poorly for a limited number of passages in human, monkey, rodent, rabbit or chick embryo cells. In the T-23 cells, the virus behaved as members of the subgroup B of herpesvirus, in that the virus remained primarily cell associated.


2021 ◽  
pp. 135910452110055
Author(s):  
Lucie Smith ◽  
Esther Crawley ◽  
Madeleine Riley ◽  
Megan McManus ◽  
Maria Elizabeth Loades

Background: Chronic Fatigue Syndrome (CFS/ME) may get in the way of enjoying activities. A substantial minority of adolescents with CFS/ME are depressed. Anhedonia is a core symptom of depression. Anhedonia in adolescents with CFS/ME has not been previously investigated. Method: One hundred and sixty-four adolescents, age 12 to 18, with CFS/ME completed a diagnostic interview (K-SADS) and questionnaires (HADS, RCADS). We used a mixed-methods approach to explore the experience of anhedonia and examine how common it is, comparing those with clinically significant anhedonia to those without. Results: Forty-two percent of adolescents with CFS/ME reported subclinical or clinical levels of anhedonia. Fifteen percent had clinically significant anhedonia. Thematic analysis generated two themes: (1) stopping activities that they previously enjoyed and (2) CFS/ME obstructs enjoyment. Most (72%) of those who reported clinically significant anhedonia met the depression diagnostic criteria. Those who were depressed used more negative language to describe their experience of activities than in those who were not depressed, although the themes were broadly similar. Conclusions: Experiencing pleasure from activities may be affected in CFS/ME, particularly in those who are depressed. Anhedonia may get in the way of behavioural strategies used within CFS/ME treatments.


1999 ◽  
Vol 14 (3) ◽  
pp. 181-184 ◽  
Author(s):  
T. Wada ◽  
S. Kawakatsu ◽  
T. Nadaoka ◽  
N. Okuyama ◽  
K. Otani

Primates ◽  
1974 ◽  
Vol 15 (2-3) ◽  
pp. 227-234 ◽  
Author(s):  
O. Elliot ◽  
N. A. Holtzman ◽  
V. A. McKusick
Keyword(s):  

2001 ◽  
Vol 115 (4) ◽  
pp. 344-350 ◽  
Author(s):  
Alessandro Bartolomucci ◽  
Gabriel de Biurrun ◽  
Eberhard Fuchs

2008 ◽  
Vol 18 ◽  
pp. S348 ◽  
Author(s):  
E. Fuchs ◽  
S. Corbach-Söhle ◽  
B. Schmelting ◽  
E. Mocaer ◽  
M.J. Millan ◽  
...  

2018 ◽  
Vol 1 (2) ◽  
pp. 152-161 ◽  
Author(s):  
Yu-Qiong Zhao ◽  
Ya-Qian Liu ◽  
Ji-Fang Yuan ◽  
Xin Dai ◽  
Miao-Miao Niu ◽  
...  
Keyword(s):  
Β Cells ◽  

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