scholarly journals Glutamate Carboxypeptidase II Inhibition Behaviorally and Physiologically Improves Pyridoxine-Induced Neuropathy in Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e102936 ◽  
Author(s):  
Michelle C. Potter ◽  
Krystyna M. Wozniak ◽  
Noelle Callizot ◽  
Barbara S. Slusher
2012 ◽  
Vol 55 (12) ◽  
pp. 5922-5932 ◽  
Author(s):  
Doris Stoermer ◽  
Dilrukshi Vitharana ◽  
Niyada Hin ◽  
Greg Delahanty ◽  
Bridget Duvall ◽  
...  

2013 ◽  
Vol 438 (4) ◽  
pp. 765-771 ◽  
Author(s):  
Suk Kyung Lee ◽  
Hyunyoung Kim ◽  
You-Hoon Cheong ◽  
Min-Ju Kim ◽  
Sangmee Ahn Jo ◽  
...  

2007 ◽  
Vol 50 (14) ◽  
pp. 3267-3273 ◽  
Author(s):  
Cyril Bařinka ◽  
Miroslava Rovenská ◽  
Petra Mlčochová ◽  
Klára Hlouchová ◽  
Anna Plechanovová ◽  
...  

2021 ◽  
Vol 13 ◽  
Author(s):  
Dibyadeep Datta ◽  
Shannon N. Leslie ◽  
Elizabeth Woo ◽  
Nishita Amancharla ◽  
Ayah Elmansy ◽  
...  

Glutamate carboxypeptidase II (GCPII) expression in brain is increased by inflammation, and reduces NAAG (N-acetyl aspartyl glutamate) stimulation of mGluR3 signaling. Genetic insults in this signaling cascade are increasingly linked to cognitive disorders in humans, where increased GCPII and or decreased NAAG-mGluR3 are associated with impaired prefrontal cortical (PFC) activation and cognitive impairment. As aging is associated with increased inflammation and PFC cognitive deficits, the current study examined GCPII and mGluR3 expression in the aging rat medial PFC, and tested whether GCPII inhibition with 2-(3-mercaptopropyl) pentanedioic acid (2-MPPA) would improve working memory performance. We found that GCPII protein was expressed on astrocytes and some microglia as expected from previous studies, but was also prominently expressed on neurons, and showed increased levels with advancing age. Systemic administration of the GCPII inhibitor, 2-MPPA, improved working memory performance in young and aged rats, and also improved performance after local infusion into the medial PFC. As GCPII inhibitors are well-tolerated, they may provide an important new direction for treatment of cognitive disorders associated with aging and/or inflammation.


2017 ◽  
Vol 234 (11) ◽  
pp. 1671-1681 ◽  
Author(s):  
Callum Hicks ◽  
Ryan A. Gregg ◽  
Sunil U. Nayak ◽  
Lee Anne Cannella ◽  
Giana J. Schena ◽  
...  

2011 ◽  
Vol 1371 ◽  
pp. 82-86 ◽  
Author(s):  
Yuto Takatsu ◽  
Yuko Fujita ◽  
Takashi Tsukamoto ◽  
Barbara S. Slusher ◽  
Kenji Hashimoto

Author(s):  
Ajit G. Thomas ◽  
Krystyna M. Wozniak ◽  
Takashi Tsukamoto ◽  
David Calvin ◽  
Ying Wu ◽  
...  

2018 ◽  
Vol 27 (9) ◽  
pp. 1575-1584 ◽  
Author(s):  
Jakub Ptacek ◽  
Jana Nedvedova ◽  
Michal Navratil ◽  
Barbora Havlinova ◽  
Jan Konvalinka ◽  
...  

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