scholarly journals Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132932 ◽  
Author(s):  
Benjamin A. King ◽  
Carlos Parra ◽  
Yimei Li ◽  
Kathleen J. Helton ◽  
Ibrahim Qaddoumi ◽  
...  
2018 ◽  
Vol 5 (3) ◽  
pp. 175-187 ◽  
Author(s):  
O. V. Gorovtsova ◽  
T. L. Ushakova ◽  
V. G. Polyakov

Retinoblastoma is one of highly curable diseases; today the total 5-year survival rate in patients with retinoblastoma exceeds 95%. The article summarizes the current world experience on treatment of patients with intraocular retinoblastoma. The treating skills of intraocular malignant tumor in children are a balance between the patient’s life and the preservation of an eye and its visual functions. The complex and challenging task is the treatment of common intraocular retinoblastoma groups «C», «D», «E» when the large size or localization of the tumor does not allow performing the local (focal) destruction of the tumor. As a rule, in such cases neoadjuvant chemotherapy (CT) is performed at the first stage in order to reduce the size of the tumor for further focal therapy. However, the analysed data on the effectiveness of neoadjuvant CT in combination with focal or radiotherapy demonstrated the limited possibilities of the proposed therapy. Local drug delivery in cancer therapy became a real breakthrough in the organ-preserving treatment of children with large intraocular retinoblastoma. The most widely used current methods of local drug delivery are intravitreal (IVitC) and selective intra-arterial chemotherapy (SIAC) as monotherapy or in combination with neoadjuvant CT and focal therapy which significantly increased the percentage of preserved eyes without radiotherapy administration or damage to the patient survival. The review discusses the different IVitC and SIAC techniques, chemotherapy schemes, dosages of chemotherapy, immediate and long-term complications of treatment.


Ecography ◽  
2020 ◽  
Vol 43 (4) ◽  
pp. 569-580 ◽  
Author(s):  
Andreas P. Wion ◽  
Peter J. Weisberg ◽  
Ian S. Pearse ◽  
Miranda D. Redmond

2021 ◽  
Vol 68 (5) ◽  
Author(s):  
Jesse L. Berry ◽  
Francis L. Munier ◽  
Brenda L. Gallie ◽  
Ashley Polski ◽  
Sona Shah ◽  
...  

Water ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 404
Author(s):  
Tong Heng ◽  
Xinlin He ◽  
Lili Yang ◽  
Jiawen Yu ◽  
Yulin Yang ◽  
...  

To reveal the spatiotemporal patterns of the asymmetry in the Tianshan mountains’ climatic warming, in this study, we analyzed climate and MODIS snow cover data (2001–2019). The change trends of asymmetrical warming, snow depth (SD), snow coverage percentage (SCP), snow cover days (SCD) and snow water equivalent (SWE) in the Tianshan mountains were quantitatively determined, and the influence of asymmetrical warming on the snow cover activity of the Tianshan mountains were discussed. The results showed that the nighttime warming rate (0.10 °C per decade) was greater than the daytime, and that the asymmetrical warming trend may accelerate in the future. The SCP of Tianshan mountain has reduced by 0.9%. This means that for each 0.1 °C increase in temperature, the area of snow cover will reduce by 5.9 km2. About 60% of the region’s daytime warming was positively related to SD and SWE, and about 48% of the region’s nighttime warming was negatively related to SD and SWE. Temperature increases were concentrated mainly in the Pamir Plateau southwest of Tianshan at high altitudes and in the Turpan and Hami basins in the east. In the future, the western and eastern mountainous areas of the Tianshan will continue to show a warming trend, while the central mountainous areas of the Tianshan mountains will mainly show a cooling trend.


Acta Tropica ◽  
2021 ◽  
Vol 217 ◽  
pp. 105861
Author(s):  
Ismail Zeb ◽  
Naveeda Akhter Qureshi ◽  
Nargis Shaheen ◽  
Mazhar Iqbal Zafar ◽  
Abid Ali ◽  
...  

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