Modifiable Prognostic Factors of Hepatocellular Carcinoma in Patients with Non-Surgical Treatment

305 Background: Many liver staging systems that include the tumor stage and the extent of liver function have been developed. However, Prognosis assessment for hepatocellular carcinoma (HCC) remains controversial. In this study, the performances of 7 staging systems were compared in a cohort of patients with HCC who underwent non-surgical treatment. Methods: A total of 196 consecutive patients with HCC who underwent non-surgical treatment seen between January 1, 2004, and December 31, 2007, were included. Performances of TNM sixth edition, Okuda, Barcelona Clinic Liver Cancer (BCLC), Cancer of the Liver Italian Program (CLIP), Chinese University Prognostic Index (CUPI), Japan Integrated Staging (JIS), and China integrated score (CIS) have been compared and ranked using concordance index (c-index). Predictors of survival were identified using univariate and multivariate Cox model analyses. Results: The median survival time for the cohort was 7.6 months (95% CI 5.6-9.7). The independent predictors of survival were performance status (P <.001), serum sodium (P <.001), alkaline phosphatase (P <.001), tumor diameter greater than 5 cm (P =.001), portal vein invasion (P <.001), lymph node metastasis (P =.025), distant metastasis (P =.004). CUPI staging system had the best independent predictive power for survival when compared with the other six prognostic systems. Performance status and serum sodium improved the discriminatory ability of CUPI. Conclusions: In our selected patient population whose main etiology is hepatitis B, CUPI was the most suitable staging systems in predicting survival in patients with unresectable HCC. BCLC was the second top-ranking staging system. CLIP, JIS, CIS, and TNM sixth edition were not helpful in predicting survival outcome, and their use is not supported by our data. Clinical trial information: 1103-10.

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Non-surgical treatment of hepatocellular carcinoma

Journal of Gastroenterology and Hepatology ◽

10.1111/j.1440-1746.1997.tb00516.x ◽

1997 ◽

Vol 12 (9-10) ◽

pp. S319-S328 ◽

Cited By ~ 94

Author(s):

DENG-YN LIN ◽

SHI-MING LIN ◽

YUN-FAN LIAW

Keyword(s):

Hepatocellular Carcinoma ◽

Surgical Treatment ◽

Non Surgical Treatment

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Effect of radiofrequency ablation for the local recurrent lesion of hepatocellular carcinoma after non-surgical treatment

Journal of Hepatology ◽

10.1016/s0168-8278(02)80769-3 ◽

2002 ◽

Vol 36 ◽

pp. 215

Author(s):

Koichi Haruyama ◽

Akiko Saito ◽

Hideki Nozawa ◽

Kenji Hanada ◽

Masami Kikuzato ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Surgical Treatment ◽

Radiofrequency Ablation ◽

Recurrent Lesion ◽

Non Surgical Treatment

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Hepatocellular carcinoma: Screening and non‐surgical treatment

Annals of the College of Surgeons Hong Kong ◽

10.1046/j.1442-2034.1999.00033.x ◽

1999 ◽

Vol 3 (4) ◽

pp. 107-111

Author(s):

Yuen Man‐Fung ◽

Lai Ching‐Lung

Keyword(s):

Hepatocellular Carcinoma ◽

Surgical Treatment ◽

Hepatocellular Carcinoma Screening ◽

Non Surgical Treatment

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Prognostic factors affecting the short-term efficacy of non-surgical treatment of chronic periodontitis: a multilevel modelling analysis

10.21203/rs.3.rs-27363/v2 ◽

2021 ◽

Author(s):

Hui-Jie Liu ◽

Bo Wang ◽

Ao-Chen Wang ◽

Dan-Hong Zhang ◽

Cui Mao ◽

...

Keyword(s):

Prognostic Factors ◽

Surgical Treatment ◽

Multilevel Modelling ◽

Short Term ◽

Clinical Attachment Loss ◽

Factors Affecting ◽

Term Efficacy ◽

Probing Depth ◽

Modelling Analysis ◽

Non Surgical Treatment

Abstract Background: This current study is aimed to analyze the prognostic factors affecting the short-term efficacy of non-surgical treatment of patients in periodontitis from stage Ⅱ to stage Ⅳ by the multilevel modelling analysis.Materials and Methods: A total of 58 patients with chronic periodontitis were included in this study. Patients were clinically explored before and 3 months after the treatment and the difference in probing depth was determined [ Reduction of probing depth (Δ PD) = baseline PD - finial probing depth (FPD)]. Three different levels were analyzed: patients, teeth and sites to construct a multi-layer linear model.Results: Probing depth (PD) improved significantly compared with that before treatment (p < 0.05), in which FPD was (3.90±1.39) mm, and the ΔPD was (1.79±0.97) mm. Compared with the mesial sites and distal sites of the multi-rooted teeth, the number of PD ≥ 5mm or PD < 5mm after the treatment was significantly different (P < 0.05), and the proportion of PD < 5mm was higher in mesial sites. The null model showed that Δ PD varied greatly between groups at various levels (P <0.001), with prediction variable of site level, tooth level, and patient level accounted for 66%, 18%, and 16% of the overall difference, respectively. The complete model showed that the Δ PD of smokers was significantly lower than that of non-smokers (P < 0.001). The Δ PD of the mesial and distal sites was larger than that of the buccolingual central site (P < 0.001). The Δ PD of single-rooted teeth was larger than that of multi-rooted teeth (P < 0.001). The baseline PD, tooth mobility (TM), bleeding index (BI), clinical attachment loss (CAL) were significantly negatively correlated with Δ PD (P < 0.001). Conclusions: Patients with periodontitis from stage Ⅱ to stage Ⅳ, who are non-smoking, have good compliance, good awareness of oral health, and low percentage sites with PD ≥ 5mm at baseline, single rooted teeth with hypomobility, less clinical attachment loss and lower bleeding index and sites of mesial or distal can obtain an ideal short-term efficacy of non-surgical treatment.

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