scholarly journals Role of Muscarinic Acetylcholine Receptors in Serial Feature-Positive Discrimination Task during Eyeblink Conditioning in Mice

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147572
Author(s):  
Md. Ashrafur Rahman ◽  
Norifumi Tanaka ◽  
Koji Usui ◽  
Shigenori Kawahara
Keyword(s):  
Acetylcholine Receptors ◽  
Discrimination Task ◽  
Eyeblink Conditioning ◽  
Muscarinic Acetylcholine Receptors ◽  
Muscarinic Acetylcholine ◽  
Positive Discrimination ◽  
Feature Positive

scholarly journals Blockade of the M1 muscarinic acetylcholine receptors impairs eyeblink serial feature-positive discrimination learning in mice

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237451
Author(s):  
Md Ashrafur Rahman ◽  
Norifumi Tanaka ◽  
Md. Nuruzzaman ◽  
Shandhya DebNath ◽  
Shigenori Kawahara
Keyword(s):  
Discrimination Learning ◽  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptors ◽  
Muscarinic Acetylcholine ◽  
Positive Discrimination ◽  
M1 Muscarinic ◽  
Feature Positive

scholarly journals The Role of Spinal Muscarinic Acetylcholine Receptors in Clonidine-Induced Anti-nociceptive Effects in Rats

2003 ◽  
Vol 26 (8) ◽  
pp. 1178-1180 ◽  
Author(s):  
Kenji Honda ◽  
Namiko Murao ◽  
Takae Ibuki ◽  
Hiro-o Kamiya ◽  
Yukio Takano
Keyword(s):  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptors ◽  
Muscarinic Acetylcholine

scholarly journals Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice

2011 ◽  
Vol 300 (5) ◽  
pp. H1602-H1608 ◽  
Author(s):  
Adrian Gericke ◽  
Jan J. Sniatecki ◽  
Veronique G. A. Mayer ◽  
Evgeny Goloborodko ◽  
Andreas Patzak ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscarinic Receptor ◽  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptors ◽  
Receptor Subtypes ◽  
Wild Type ◽  
Luminal Diameter ◽  
Small Arteries ◽  
Muscarinic Acetylcholine

Acetylcholine regulates perfusion of numerous organs via changes in local blood flow involving muscarinic receptor-induced release of vasorelaxing agents from the endothelium. The purpose of the present study was to determine the role of M1, M3, and M5 muscarinic acetylcholine receptors in vasodilation of small arteries using gene-targeted mice deficient in either of the three receptor subtypes (M1R−/−, M3R−/−, or M5R−/− mice, respectively). Muscarinic receptor gene expression was determined in murine cutaneous, skeletal muscle, and renal interlobar arteries using real-time PCR. Moreover, respective arteries from M1R−/−, M3R−/−, M5R−/−, and wild-type mice were isolated, cannulated with micropipettes, and pressurized. Luminal diameter was measured using video microscopy. mRNA for all five muscarinic receptor subtypes was detected in all three vascular preparations from wild-type mice. However, M3 receptor mRNA was found to be most abundant. Acetylcholine produced dose-dependent dilation in all three vascular preparations from M1R−/−, M5R−/−, and wild-type mice. In contrast, cholinergic dilation was virtually abolished in arteries from M3R−/− mice. Deletion of either M1, M3, or M5 receptor genes did not affect responses to nonmuscarinic vasodilators, such as substance P and nitroprusside. These findings provide the first direct evidence that M3 receptors mediate cholinergic vasodilation in cutaneous, skeletal muscle, and renal interlobar arteries. In contrast, neither M1 nor M5 receptors appear to be involved in cholinergic responses of the three vascular preparations tested.

scholarly journals Different role of muscarinic acetylcholine receptors (mAChR) in the urethral smooth muscle of male rabbit

1997 ◽  
Vol 73 ◽  
pp. 281
Author(s):  
Katsushi Nagahama ◽  
Toshihiko Tsujii ◽  
Hiroshi Azuma ◽  
Takashi Morita ◽  
Hiroyuki Oshima
Keyword(s):  
Smooth Muscle ◽  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptors ◽  
Male Rabbit ◽  
Muscarinic Acetylcholine ◽  
Urethral Smooth Muscle

scholarly journals Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors

2008 ◽  
Vol 3 ◽  
pp. 20 ◽  
Author(s):  
Valerie A Mosser ◽  
Kymry T Jones ◽  
Katie M Hoffman ◽  
Nael A McCarty ◽  
Darrell A Jackson
Keyword(s):  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptors ◽  
Down Regulation ◽  
Muscarinic Acetylcholine

scholarly journals Choline Produces Cytoprotective Effects Against Ischemic Myocardial Injuries: Evidence for the Role of Cardiac M3 Subtype Muscarinic Acetylcholine Receptors

2005 ◽  
Vol 16 (4-6) ◽  
pp. 163-174 ◽  
Author(s):  
Baofeng Yang ◽  
Huixian Lin ◽  
Chaoqian Xu ◽  
Yan Liu ◽  
Huizhen Wang ◽  
...  
Keyword(s):  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptors ◽  
Muscarinic Acetylcholine ◽  
Myocardial Injuries

Effect of low dose metronomic therapy on MCF-7 tumor cells growth and angiogenesis. Role of muscarinic acetylcholine receptors

2020 ◽  
Vol 84 ◽  
pp. 106514
Author(s):  
A.R. Salem ◽  
P. Martínez Pulido ◽  
F. Sanchez ◽  
Y. Sanchez ◽  
A.J. Español ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Acetylcholine Receptors ◽  
Low Dose ◽  
Muscarinic Acetylcholine Receptors ◽  
Muscarinic Acetylcholine ◽  
Metronomic Therapy ◽  
Mcf 7
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