scholarly journals CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0156072 ◽  
Author(s):  
Bonnie Huang ◽  
Julio Gomez-Rodriguez ◽  
Silvia Preite ◽  
Lisa J. Garrett ◽  
Ursula L. Harper ◽  
...  
Keyword(s):  
2005 ◽  
Vol 201 (6) ◽  
pp. 833-836 ◽  
Author(s):  
Christine Borowski ◽  
Albert Bendelac

New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing NKT cell development. In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells.


2008 ◽  
Vol 38 (10) ◽  
pp. 2689-2696 ◽  
Author(s):  
Lauren A. Pitt ◽  
Francois-Xavier Hubert ◽  
Hamish S. Scott ◽  
Dale I. Godfrey ◽  
Stuart P. Berzins

2007 ◽  
Vol 7 (7) ◽  
pp. 505-518 ◽  
Author(s):  
Dale I. Godfrey ◽  
Stuart P. Berzins

Blood ◽  
2008 ◽  
Vol 112 (13) ◽  
pp. 4905-4914 ◽  
Author(s):  
Ryan D. Schulteis ◽  
Haiyan Chu ◽  
Xuezhi Dai ◽  
Yuhong Chen ◽  
Brandon Edwards ◽  
...  

Abstract The loss of Gimap5 (GTPase of the immune-associated protein 5) gene function is the underlying cause of lymphopenia and autoimmune diabetes in the BioBreeding (BB) rat. The in vivo function of murine gimap5 is largely unknown. We show that selective gene ablation of the mouse gimap5 gene impairs the final intrathymic maturation of CD8 and CD4 T cells and compromises the survival of postthymic CD4 and CD8 cells, replicating findings in the BB rat model. In addition, gimap5 deficiency imposes a block of natural killer (NK)- and NKT-cell differentiation. Development of NK/NKT cells is restored on transfer of gimap5−/− bone marrow into a wild-type environment. Mice lacking gimap5 have a median survival of 15 weeks, exhibit chronic hepatic hematopoiesis, and in later stages show pronounced hepatocyte apoptosis, leading to liver failure. This pathology persists in a Rag2-deficient background in the absence of mature B, T, or NK cells and cannot be adoptively transferred by transplanting gimap5−/− bone marrow into wild-type recipients. We conclude that mouse gimap5 is necessary for the survival of peripheral T cells, NK/NKT-cell development, and the maintenance of normal liver function. These functions involve cell-intrinsic as well as cell-extrinsic mechanisms.


2006 ◽  
Vol 203 (10) ◽  
pp. 2229-2232 ◽  
Author(s):  
Dale I. Godfrey ◽  
Malcolm J. McConville ◽  
Daniel G. Pellicci

Natural killer T cells (NKT cells) are selected in the thymus by self-glycolipid antigens presented by CD1d molecules. It is currently thought that one specific component of the lysosomal processing pathway, which leads to the production of isoglobotrihexosylceramide (iGb3), is essential for normal NKT cell development. New evidence now shows that NKT cell development can be disrupted by a diverse range of mutations that interfere with different elements of the lysosomal processing and degradation of glycolipids. This suggests that lysosomal storage diseases (LSDs) in general, rather than one specific defect, can disrupt CD1d antigen presentation, leading to impaired development of NKT cells.


2009 ◽  
Vol 8 (6) ◽  
pp. 2740-2751 ◽  
Author(s):  
Yunsen Li ◽  
Prakash Thapa ◽  
David Hawke ◽  
Yuji Kondo ◽  
Keiko Furukawa ◽  
...  

2010 ◽  
Vol 6 (5) ◽  
pp. e1000915 ◽  
Author(s):  
He Yuling ◽  
Xiao Ruijing ◽  
Ji Xiang ◽  
Li Li ◽  
Chen Lang ◽  
...  
Keyword(s):  

2010 ◽  
Vol 184 (12) ◽  
pp. 6822-6832 ◽  
Author(s):  
Amy M. Becker ◽  
Jon S. Blevins ◽  
Farol L. Tomson ◽  
Jennifer L. Eitson ◽  
Jennifer J. Medeiros ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document