scholarly journals Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0185048 ◽  
Author(s):  
Zhenqiang Lei ◽  
Zhen Zhu ◽  
Bai ma ci wang ◽  
Hong mei ◽  
Hong Li ◽  
...  
Keyword(s):  
Human Adenovirus ◽  
Adenovirus Type ◽  
Epidemic Keratoconjunctivitis ◽  
Autonomous Region ◽  
Tibet Autonomous Region ◽  
The Tibet Autonomous Region

scholarly journals New records of Celaenorrhinus pyrrha de Nicéville, 1889 and C. munda (Moore, 1884) from China (Lepidoptera, Hesperiidae)

ZooKeys ◽  
2020 ◽  
Vol 985 ◽  
pp. 61-70
Author(s):  
Guo-Xi Xue ◽  
Yutaka Inayoshi ◽  
Meng Li ◽  
Fu-Ming Zhang ◽  
Da-Kun Lai ◽  
...  
Keyword(s):  
Gene Sequence ◽  
New Records ◽  
Morphological Characters ◽  
Coi Gene ◽  
Distribution Map ◽  
Male Specimen ◽  
Autonomous Region ◽  
Tibet Autonomous Region ◽  
First Time ◽  
The Tibet Autonomous Region

Celaenorrhinus pyrrha de Nicéville, 1889, a rare species of Hesperiidae previously known to be distributed from northeastern India to Indochina, is reported from southwestern Yunnan and southwestern Chongqing, China. A 658 bp COI gene sequence of this species is published for the first time. Although Chongqing is obviously isolated from the main distribution range, morphological characters of the specimens from this locality do not indicate a subspecies differentiation. Another rare taxon, C. munda munda (Moore, 1884), is also recorded from China for the first time based upon a male specimen from Cuona County in the Tibet Autonomous Region. This is the second specimen of C. munda from China, over 100 years after the holotype of C. munda joka Evans, 1949. The genitalia of both species are illustrated and described. Some taxonomic notes and a distribution map are provided as well.

scholarly journals Prevalence of Brick Tea-Type Fluorosis in the Tibet Autonomous Region

2016 ◽  
Vol 26 (2) ◽  
pp. 57-63 ◽  
Author(s):  
Zhipeng Fan ◽  
Yanhui Gao ◽  
Wei Wang ◽  
Hongqiang Gong ◽  
Min Guo ◽  
...  
Keyword(s):  
Autonomous Region ◽  
Tibet Autonomous Region ◽  
The Tibet Autonomous Region

Newly recognised languages in Chamdo

2019 ◽  
Vol 42 (1) ◽  
pp. 38-81 ◽  
Author(s):  
Tashi Nyima ◽  
Hiroyuki Suzuki
Keyword(s):  
Linguistic Analysis ◽  
Historical Narrative ◽  
Historical Background ◽  
Autonomous Region ◽  
Endangered Language ◽  
Tibet Autonomous Region ◽  
The Tibet Autonomous Region

Abstract This article presents information regarding newly recognised non-Tibetic Tibeto-Burman languages spoken in three counties, Dzogang, Markham, and Drag-yab, of Chamdo Municipality and the adjacent Dzayul County in the Tibet Autonomous Region. First, we introduce four languages – Lamo, Larong sMar, Drag-yab sMar, and gSerkhu – identifying the location of each language on the Chinese administrative map as well as the numbers of speakers of the languages. Second, we provide a brief historical background on these languages, which suggests a relationship between them and Qiangic groups. Third, we display lexical evidence that shows not only their non-Tibetic features but also their closeness to Qiangic languages. Finally, the article focuses on Lamo, an endangered language spoken in Dzogang County, and provides a linguistic analysis of an annotated Lamo historical narrative in the Appendix.

scholarly journals Decoy Receptor Interactions as Novel Drug Targets against EKC-Causing Human Adenovirus

Viruses ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 242 ◽  
Author(s):  
Naresh Chandra ◽  
Lars Frängsmyr ◽  
Niklas Arnberg
Keyword(s):  
Drug Targets ◽  
Antiviral Drug ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Antiviral Effect ◽  
Epidemic Keratoconjunctivitis ◽  
Virus Binding ◽  
Decoy Receptor ◽  
Decoy Receptors ◽  
Approved Drugs

Epidemic keratoconjunctivitis (EKC) is a severe ocular disease and can lead to visual impairment. Human adenovirus type-37 (HAdV-D37) is one of the major causative agents of EKC and uses sialic acid (SA)-containing glycans as cellular receptors. Currently, there are no approved antivirals available for the treatment of EKC. Recently, we have reported that sulfated glycosaminoglycans (GAGs) bind to HAdV-D37 via the fiber knob (FK) domain of the viral fiber protein and function as decoy receptors. Based on this finding, we speculated that GAG-mimetics may act as artificial decoy receptors and inhibit HAdV-D37 infection. Repurposing of approved drugs to identify new antivirals has drawn great attention in recent years. Here, we report the antiviral effect of suramin, a WHO-approved drug and a widely known GAG-mimetic, against HAdV-D37. Commercially available suramin analogs also show antiviral effects against HAdV-D37. We demonstrate that suramin exerts its antiviral activity by inhibiting the attachment of HAdV-D37 to cells. We also reveal that the antiviral effect of suramin is HAdV species-specific. Collectively, in this proof of concept study, we demonstrate for the first time that virus binding to a decoy receptor constitutes a novel and an unexplored target for antiviral drug development.

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