epidemic keratoconjunctivitis
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2022 ◽  
Aynura Sariyeva Aydamirov ◽  
Ibrahim Inan Harbiyeli ◽  
Gokhan Ozturk ◽  
Fugen Yarkin ◽  
Elif Erdem ◽  

Abstract Purpose: To evaluate the in vitro efficacy of cidofovir, ganciclovir, povidone iodine, chlorhexidine, and cyclosporine A on adenovirus genotype 8 Methods: Conjunctival samples were collected from patients with adenoviral conjunctivitis and cultured in A549 cells. Adenovirus diagnosis was confirmed by RT-PCR. For each drug, the 50% cytotoxic concentration (CC₅₀) was determined. Subsequently, the antiviral activity was tested at concentrations below CC₅₀, and the 50% inhibitor concentration (IC₅₀) of drugs was determined.Results: While the IC₅₀ of cidofovir against adenovirus genotype 8 was 3.07 ± 0.8 µM, ganciclovir, povidone iodine, chlorhexidine, and cyclosporine A were not found to be effective against adenovirus genotype 8 at concentrations below the CC₅₀ value.Conclusions: Cidofovir was found effective and the IC₅₀ value was within the ranges in the literature. Ganciclovir and cyclosporine A were found to be ineffective at doses below the cytotoxic dose, povidone iodine and chlorhexidine were found to be highly cytotoxic.

Viruses ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2505
Jaya Rajaiya ◽  
Amrita Saha ◽  
Xiaohong Zhou ◽  
James Chodosh

Notable among the many communicable agents known to infect the human cornea is the human adenovirus, with less than ten adenoviruses having corneal tropism out of more than 100 known types. The syndrome of epidemic keratoconjunctivitis (EKC), caused principally by human adenovirus, presents acutely with epithelial keratitis, and later with stromal keratitis that can be chronic and recurrent. In this review, we discuss the current state of knowledge regarding the molecular biology of adenovirus infection of corneal stromal cells, among which the fibroblast-like keratocyte is the most predominant, in order to elucidate basic pathophysiologic mechanisms of stromal keratitis in the human patient with EKC.

Cristina Martin ◽  
Ursula Löw ◽  
Adrien Quintin ◽  
Gesine Schießl ◽  
Barbara Gärtner ◽  

Abstract Purpose Epidemic keratoconjunctivitis (EKC) is one of the most severe ocular viral infections. The aim of this interruptive time series study was to quantitatively evaluate the effectiveness of a hygienic EKC outbreak management concept developed in our ophthalmological department. Methods All patients with suspected EKC in the period from August to November 2018 were included in the study. Data were retrospectively collected from the patient’s medical documents and records. The disease was diagnosed clinically and confirmed by virus detection through polymerase chain reaction (PCR) from conjunctival swabs. With the beginning of the epidemic, an outbreak management plan was implemented to reduce the nosocomial spread. Results The outbreak lasted 77 days (20th August 2018 to 4th November 2018) and affected a total of 120 patients. This corresponds to a mean of 1.5 patients per outbreak day. The median age was 58 [1–92] years. Of all patients, 61 (50.8%) were female. Conjunctival swabs were collected in 100/120 (83.3%) cases, the adenovirus being detected in all positive smears (63/63, 100%). The implementation of our outbreak management plan reduced significantly the number of EKC cases per outbreak day and resulted in a reduction of the basic reproduction number by a factor of 2.2. Conclusion The detection of EKC together with the immediate implementation of hygienic outbreak measures can significantly reduce the spread of infection. The implementation of a strict outbreak management concept can significantly reduce the number of EKC cases, thus avoiding possible complications and therefore unnecessary health-related costs.

2021 ◽  
pp. 99-100
A.E. Babushkin ◽  
A.M. Tulyakova ◽  
E.M. Rakhimova ◽  
E.N. Matyukhina ◽  

This article describes a clinical case of a filmy form of adenoviral epidemic keratoconjunctivitis (EKC) in an adult patient. The given case is interesting in that the onset of EKC did not foreshadow a complicated, hyperergic course of the filmy form in an adult patient. That ultimately led to cicatricial changes in the conjunctiva in the form of a partial external symblepharon. Alertness of ophthalmologists in relation to this form of EKC, which requires differential diagnosis, first of all, with true toxic diphtheria lesion of the conjunctiva, is necessary. Adequate complex antiviral treatment of EKC with the use of corticosteroids, immunomodulatory and symptomatic therapy helps to stop the process. Key words: adenovirus conjunctivitis, epidemic keratoconjunctivitis, membranous form, complicated course, partial simblefaron, dry eye syndrome.

Cornea ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Siamak Khavandi ◽  
Elsa Tabibzadeh ◽  
Soheila Khavandi

2021 ◽  
Vol 33 (4) ◽  
pp. 408
Dhouha Gouider ◽  
Asma Khallouli ◽  
Afef Maalej ◽  
Sana Khochtali ◽  
Moncef Khairallah

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