scholarly journals Interaction between the cellular E3 ubiquitin ligase SIAH-1 and the viral immediate-early protein ICP0 enables efficient replication of Herpes Simplex Virus type 2 in vivo

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0201880 ◽  
Author(s):  
Julia S. Czechowicz ◽  
Claus-Henning Nagel ◽  
Maike Voges ◽  
Michael Spohn ◽  
Martha M. Eibl ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
Early Protein ◽  
Efficient Replication ◽  
Protein Icp0 ◽  
Simplex Virus

scholarly journals Herpes Simplex Virus Tegument ICP0 Is Capsid Associated, and Its E3 Ubiquitin Ligase Domain Is Important for Incorporation into Virions

2009 ◽  
Vol 84 (3) ◽  
pp. 1637-1640 ◽  
Author(s):  
Mark G. Delboy ◽  
Carlos R. Siekavizza-Robles ◽  
Anthony V. Nicola
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Ubiquitin Ligase ◽  
E3 Ubiquitin Ligase ◽  
Ring Finger ◽  
Virion Assembly ◽  
Tegument Proteins ◽  
Ubiquitin Ligase Activity ◽  
Protein Icp0 ◽  
Simplex Virus

ABSTRACT Herpes simplex virus (HSV) immediate-early (IE) protein ICP0 is a multifunctional regulator of HSV infection. ICP0 that is present in the tegument layer has not been well characterized. Protein compositions of wild-type and ICP0 null virions were similar, suggesting that the absence of ICP0 does not grossly impair virion assembly. ICP0 has a RING finger domain with E3 ubiquitin ligase activity that is necessary for IE functions. Virions with mutations in this domain contained greatly reduced levels of tegument ICP0, suggesting that the domain influences the incorporation of ICP0. Virion ICP0 was resistant to removal by detergent and salt and was associated with capsids, features common to inner tegument proteins.

Construction of a US3 lacZ insertion mutant of herpes simplex virus type 2 and characterization of its phenotype in vitro and in vivo

Virology ◽  
1992 ◽  
Vol 190 (1) ◽  
pp. 256-268 ◽  
Author(s):  
Yukihiro Nishiyama ◽  
Yoshinari Yamada ◽  
Ryutaro Kurachi ◽  
Tohru Daikoku
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Insertion Mutant ◽  
Simplex Virus

Plant products as topical microbicide candidates: assessment of in vitro and in vivo activity against herpes simplex virus type 2

1999 ◽  
Vol 42 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Krystyn Z. Bourne ◽  
Nigel Bourne ◽  
Shirley F. Reising ◽  
Lawrence R. Stanberry
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Plant Products ◽  
Simplex Virus ◽  
Topical Microbicide

scholarly journals Alphaherpesvirus Proteins Related to Herpes Simplex Virus Type 1 ICP0 Induce the Formation of Colocalizing, Conjugated Ubiquitin

2001 ◽  
Vol 75 (11) ◽  
pp. 5357-5362 ◽  
Author(s):  
Jane Parkinson ◽  
Roger D. Everett
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Ubiquitin Ligase ◽  
Herpes Simplex Virus Type ◽  
E3 Ubiquitin Ligase ◽  
Ring Finger ◽  
Ring Finger Proteins ◽  
Simplex Virus

ABSTRACT Herpes simplex virus type 1 immediate early protein ICP0 influences virus infection by inducing the degradation of specific cellular proteins via a mechanism requiring its RING finger and the ubiquitin-proteasome pathway. Many RING finger proteins, by virtue of their RING finger domain, interact with E2 ubiquitin-conjugating enzymes and act as a component of an E3 ubiquitin ligase. We have recently shown that ICP0 induces the accumulation of colocalizing, conjugated ubiquitin, suggesting that ICP0 can act as or contribute to an E3 ubiquitin ligase. In this report we demonstrate that the ICP0-related RING finger proteins encoded by other alphaherpesviruses also induce colocalizing, conjugated ubiquitin, thereby suggesting that they act by similar biochemical mechanisms.

In Vivo Efficacy of Twice Daily Oral Treatment with N-MCT Against Herpes Simplex Virus Type 2 in Balb/C Mice

2010 ◽  
Vol 86 (1) ◽  
pp. A65 ◽  
Author(s):  
Debra Quenelle ◽  
Robert Glazer ◽  
Aquilur Rahman ◽  
Deborah Collins ◽  
Terri Rice
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Oral Treatment ◽  
In Vivo Efficacy ◽  
Simplex Virus
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