scholarly journals Transfusion of standard-issue packed red blood cells induces pulmonary vasoconstriction in critically ill patients after cardiac surgery—A randomized, double-blinded, clinical trial

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213000 ◽  
Author(s):  
Joanna Baron-Stefaniak ◽  
Gerda C. Leitner ◽  
Nina K. I. Küntzel ◽  
Elias L. Meyer ◽  
Michael J. Hiesmayr ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cardiac Surgery ◽  
Red Blood Cells ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Blood Cells ◽  
Packed Red Blood Cells ◽  
Pulmonary Vasoconstriction ◽  
Double Blinded

Packed Red Blood Cell Transfusion in the Intensive Care Unit: Limitations and Consequences

2007 ◽  
Vol 16 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Suzanne Gould ◽  
Mary Jo Cimino ◽  
David R. Gerber
Keyword(s):  
Blood Cell ◽  
Red Blood Cells ◽  
Critically Ill ◽  
Red Blood Cell ◽  
Critically Ill Patients ◽  
Blood Cells ◽  
Case Series ◽  
Red Blood Cell Transfusion ◽  
Packed Red Blood Cells ◽  
Pubmed Database

• Objective To review the literature on the limitations and consequences of packed red blood cell transfusions, with particular attention to critically ill patients. • Methods The PubMed database of the National Library of Medicine was searched to find published articles on the indications, clinical utility, limitations, and consequences of red blood cell transfusion, especially in critically ill patients. • Results Several dozen papers were reviewed, including case series, meta-analyses, and retrospective and prospective studies evaluating the physiological effects, clinical efficacy, and consequences and complications of transfusion of packed red blood cells. Most available data indicate that packed red blood cells have a very limited ability to augment oxygen delivery to tissues. In addition, the overwhelming preponderance of data accumulated in the past decade indicate that patients receiving such transfusions have significantly poorer outcomes than do patients not receiving such transfusions, as measured by a variety of parameters including, but not limited to, death and infection. • Conclusions According to the available data, transfusion of packed red blood cells should be reserved only for situations in which clear physiological indicators for transfusion are present.

scholarly journals Mild Acquired Factor XIII Deficiency and Clinical Relevance at the ICU—A Retrospective Analysis

2021 ◽  
Vol 27 ◽  
pp. 107602962110247
Author(s):  
Felix Carl Fabian Schmitt ◽  
Maik von der Forst ◽  
Wolfgang Miesbach ◽  
Sebastian Casu ◽  
Markus Alexander Weigand ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Blood Cells ◽  
Clinical Relevance ◽  
Fresh Frozen Plasma ◽  
Early Management ◽  
Packed Red Blood Cells ◽  
Fxiii Activity ◽  
Fxiii Deficiency

Acquired FXIII deficiency is a relevant complication in the perioperative setting; however, we still have little evidence about the incidence and management of this rarely isolated coagulopathy. This study aims to help find the right value for the substitution of patients with an acquired mild FXIII deficiency. In this retrospective single-center cohort study, we enrolled critically ill patients with mild acquired FXIII deficiency (>5% and ≤70%) and compared clinical and laboratory parameters, as well as pro-coagulatory treatments. The results of the present analysis of 104 patients support the clinical relevance of FXIII activity out of the normal range. Patients with lower FXIII levels, beginning at <60%, had lower minimum and maximum hemoglobin values, corresponding to the finding that patients with a minimum FXIII activity of <50% needed significantly more packed red blood cells. FXIII activity correlated significantly with general coagulation markers such as prothrombin time, activated partial thromboplastin time, and fibrinogen. Nevertheless, comparing the groups with a cut-off of 50%, the amount of fresh frozen plasma, thrombocytes, PPSB, AT-III, and fibrinogen given did not differ. These results indicate that a mild FXIII deficiency occurring at any point of intensive care unit stay is also probably relevant for the total need of packed red blood cells, independent of pro-coagulatory management. In alignment with the ESAIC guidelines, the measurement of FXIII in critically ill patients with the risk of bleeding and early management, with the substitution of FXIII at levels <50%-60%, could be suggested.

Transcutaneous oxygen tension monitoring in critically ill patients receiving packed red blood cells

2014 ◽  
Vol 29 (6) ◽  
pp. 1057-1062 ◽  
Author(s):  
Oliver Schlager ◽  
Michael E. Gschwandtner ◽  
Andrea Willfort-Ehringer ◽  
Martin Kurz ◽  
Markus Mueller ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Critically Ill ◽  
Oxygen Tension ◽  
Critically Ill Patients ◽  
Blood Cells ◽  
Transcutaneous Oxygen Tension ◽  
Transcutaneous Oxygen ◽  
Packed Red Blood Cells

Duration of red blood cells storage and outcome in critically ill patients

2014 ◽  
Vol 29 (3) ◽  
pp. 476.e1-476.e8 ◽  
Author(s):  
Cecile Aubron ◽  
Michael Bailey ◽  
Zoe McQuilten ◽  
David Pilcher ◽  
Colin Hegarty ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Blood Cells

A pilot feasibility trial of allocation of freshest available red blood cells versus standard care in critically ill patients

Transfusion ◽  
2011 ◽  
Vol 52 (6) ◽  
pp. 1196-1202 ◽  
Author(s):  
Cecile Aubron ◽  
Gillian Syres ◽  
Alistair Nichol ◽  
Michael Bailey ◽  
Jasmin Board ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Blood Cells ◽  
Standard Care ◽  
Feasibility Trial

scholarly journals Age of red blood cells and transfusion in critically ill patients

2013 ◽  
Vol 3 (1) ◽  
pp. 2 ◽  
Author(s):  
Cécile Aubron ◽  
Alistair Nichol ◽  
D Jamie Cooper ◽  
Rinaldo Bellomo
Keyword(s):  
Red Blood Cells ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Blood Cells
Sign in / Sign up

Export Citation Format

Share Document