scholarly journals Randomized double‐blinded clinical trial on acute transfusion reactions in dogs receiving leukoreduced versus nonleukoreduced packed red blood cells

2021 ◽  
Author(s):  
Sinziana Maria Radulescu ◽  
Ragnhild Skulberg ◽  
Charlotte McDonald ◽  
Daniel L. Chan ◽  
Karen Humm
Keyword(s):  
Clinical Trial ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Packed Red Blood Cells ◽  
Double Blinded ◽  
Transfusion Reactions

scholarly journals Transfusion of standard-issue packed red blood cells induces pulmonary vasoconstriction in critically ill patients after cardiac surgery—A randomized, double-blinded, clinical trial

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213000 ◽  
Author(s):  
Joanna Baron-Stefaniak ◽  
Gerda C. Leitner ◽  
Nina K. I. Küntzel ◽  
Elias L. Meyer ◽  
Michael J. Hiesmayr ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cardiac Surgery ◽  
Red Blood Cells ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Blood Cells ◽  
Packed Red Blood Cells ◽  
Pulmonary Vasoconstriction ◽  
Double Blinded

scholarly journals Effectiveness of buffy coat leucoreduced packed red blood cells in decreasing febrile non-hemolytic transfusion reactions in thalassemic patients

2017 ◽  
Vol 5 (5) ◽  
pp. 1756
Author(s):  
Neeti Dutt ◽  
Meena Sidhu ◽  
Sushil Sharma ◽  
Ravi Parihar ◽  
Dinesh Kumar
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Buffy Coat ◽  
Adverse Outcomes ◽  
Packed Red Blood Cells ◽  
Resource Limited ◽  
Clinical Records ◽  
A Prospective Study ◽  
Transfusion Complications ◽  
Transfusion Reactions

Background: Blood transfusions have always been associated with a number of adverse outcomes which have steadily decreased over years owing to new discoveries and technical advancements. Thalassemic patients are more prone to transfusions related complications owing to repeated transfusions. Study of these reactions and correlating them with the leucodepletion status of the transfused packed red blood cells (PRBCs) reduces transfusion complications due to the transfused leukocytes.Methods: This is a prospective study carried out on 1750 transfusions in 138 thalassemic patients at our institute between August 2015 and March 2016. The total transfusions were classified into four categories depending on the leucodepletion status of the PRBC’s. The clinical records and the reaction workup done to rule out the hemolytic reactions were recorded.Results: Reactions were recorded in 17 (0.97%) out of a total of 1750 transfusions. 14 (4.1%) reactions were recorded on transfusions of non-leukoreduced PRBCs whereas only 2 (0.16%) reactions were recorded in leucoreduced (buffy coat) PRBCs. 1 (0.8%) reaction was recorded on transfusion of leucodepleted PRBCs done by bedside filter. No reaction was documented when buffy coat leucoreduced PRBCs were used along bedside filter.Conclusions: Elimination of WBCs from donor packed cells results in reduction of adverse reactions following blood transfusion. Various methods of leucoreduction have been successfully employed in the past and shown to reduce transfusion reactions in multi transfused thalassemic patients. In resource limited settings, leukoreduction using the buffy-coat method is an effective intervention in reducing the transfusion reactions.

Do erythropoietin and a blood transfusion guideline reduce the amount of packed red blood cells transfused in a major teaching hospital?

CHEST Journal ◽  
2004 ◽  
Vol 126 (4) ◽  
pp. 871S
Author(s):  
Nam T. Ly ◽  
Brian Cuneo ◽  
William L. Jackson ◽  
Nagla Wahab ◽  
Linda Gery ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Red Blood Cells ◽  
Teaching Hospital ◽  
Blood Cells ◽  
Packed Red Blood Cells ◽  
Major Teaching Hospital ◽  
Major Teaching

The Plasma Fraction of Stored Packed Red Blood Cells Classically Activates Monocytes in Vitro

2014 ◽  
Vol 186 (2) ◽  
pp. 683
Author(s):  
J.A. Yi ◽  
K. Lo ◽  
C.C. Silliman ◽  
B.H. Edil ◽  
R.D. Schulick ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Packed Red Blood Cells ◽  
Plasma Fraction
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