scholarly journals Clinical characteristics and prevalence of dihydropteroate synthase gene mutations in Pneumocystis jirovecii-infected AIDS patients from low endemic areas of China

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0238184
Author(s):  
Mingli Zhu ◽  
Ning Ye ◽  
Jiru Xu
Keyword(s):  
Clinical Characteristics ◽  
Gene Mutations ◽  
Pneumocystis Jirovecii ◽  
Aids Patients ◽  
Dihydropteroate Synthase ◽  
Endemic Areas

Absence of Pneumocystis jirovecii dihydropteroate synthase gene mutations among samples from a group of AIDS patients in China

2009 ◽  
Vol 41 (2) ◽  
pp. 152-154 ◽  
Author(s):  
Kai Li ◽  
Ai He ◽  
Wei Ping Cai ◽  
Xiao Ping Tang ◽  
Xiao Ying Zheng ◽  
...  
Keyword(s):  
Gene Mutations ◽  
Pneumocystis Jirovecii ◽  
Aids Patients ◽  
Dihydropteroate Synthase

Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations

AIDS ◽  
2005 ◽  
Vol 19 (8) ◽  
pp. 801-805 ◽  
Author(s):  
Kristina Crothers ◽  
Charles B Beard ◽  
Joan Turner ◽  
Gena Groner ◽  
Melissa Fox ◽  
...  
Keyword(s):  
Gene Mutations ◽  
Pneumocystis Pneumonia ◽  
Pneumocystis Jirovecii ◽  
Dihydropteroate Synthase

Absence of Dihydropteroate Synthase Mutations in Pneumocystis jirovecii from Brazilian AIDS Patients

2006 ◽  
Vol 53 (4) ◽  
pp. 305-307 ◽  
Author(s):  
GUSTAVO WISSMANN ◽  
MIRIAM J. ALVAREZ-MARTINEZ ◽  
STEVEN R. MESHNICK ◽  
ADA R. S. DIHEL ◽  
JOAO C. PROLLA
Keyword(s):  
Pneumocystis Jirovecii ◽  
Aids Patients ◽  
Dihydropteroate Synthase

scholarly journals Molecular Basis of In Vivo Resistance to Sulfadoxine-Pyrimethamine in African Adult Patients Infected withPlasmodium falciparum Malaria Parasites

1998 ◽  
Vol 42 (7) ◽  
pp. 1811-1814 ◽  
Author(s):  
Leonardo K. Basco ◽  
Rachida Tahar ◽  
Pascal Ringwald
Keyword(s):  
Dihydrofolate Reductase ◽  
Point Mutations ◽  
Gene Mutations ◽  
Adult Patients ◽  
Wild Type ◽  
Dihydropteroate Synthase ◽  
Reductase Gene ◽  
Parasite Populations

ABSTRACT In vitro sulfadoxine and pyrimethamine resistance has been associated with point mutations in the dihydropteroate synthase and dihydrofolate reductase domains, respectively, but the in vivo relevance of these point mutations has not been well established. To analyze the correlation between genotype and phenotype, 10 Cameroonian adult patients were treated with sulfadoxine-pyrimethamine and followed up for 28 days. After losses to follow-up (n = 1) or elimination of DNA samples due to mixed parasite populations with pyrimethamine-sensitive and pyrimethamine-resistant profiles (n = 3), parasite genomic DNA from day 0 blood samples of six patients were analyzed by DNA sequencing. Three patients who were cured had isolates characterized by a wild-type or mutant dihydrofolate reductase gene (with one or two mutations) and a wild-type dihydropteroate synthase gene. Three other patients who failed to respond to sulfadoxine-pyrimethamine treatment carried isolates with triple dihydrofolate reductase gene mutations and either a wild-type or a mutant dihydropteroate synthase gene. Three dihydrofolate reductase gene codons (51, 59, and 108) may be reliable genetic markers that can accurately predict the clinical outcome of sulfadoxine-pyrimethamine treatment in Africa.

scholarly journals Low Prevalence of Pneumocystis pneumonia (PCP) but High Prevalence of Pneumocystis dihydropteroate synthase (dhps) Gene Mutations in HIV-Infected Persons in Uganda

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49991 ◽  
Author(s):  
Steve M. Taylor ◽  
Steven R. Meshnick ◽  
William Worodria ◽  
Alfred Andama ◽  
Adithya Cattamanchi ◽  
...  
Keyword(s):  
Gene Mutations ◽  
Pneumocystis Pneumonia ◽  
Dihydropteroate Synthase ◽  
High Prevalence ◽  
Dhps Gene ◽  
Low Prevalence
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