scholarly journals Effect of age on the gap-prepulse inhibition of the cortical N1-P2 complex in humans as a step towards an objective measure of tinnitus

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241136
Author(s):  
Yunseo Ku ◽  
Do Youn Kim ◽  
Chiheon Kwon ◽  
Tae Soo Noh ◽  
Moo Kyun Park ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
Animal Studies ◽  
Evoked Potential ◽  
Human Subjects ◽  
Acoustic Startle ◽  
Objective Measure ◽  
Acoustic Startle Reflex ◽  
Behavioral Method ◽  
The Difference ◽  
Effect Of Age

The gap-prepulse inhibition of the acoustic startle reflex has been widely used as a behavioral method for tinnitus screening in animal studies. The cortical-evoked potential gap-induced inhibition has also been investigated in animals as well as in human subjects. The present study aimed to investigate the effect of age on the cortical N1-P2 complex in the gap-prepulse inhibition paradigm. Fifty-seven subjects, aged 20 to 68 years, without continuous tinnitus, were tested with two effective gap conditions (embedded gap of 50- or 20-ms duration). Retest sessions were performed within one month. A significant gap-induced inhibition of the N1-P2 complex was found in both gap durations. Age differently affected the inhibition, depending on gap duration. With a 50-ms gap, the inhibition decreased significantly with the increase in age. This age-inhibition relationship was not found when using a 20-ms gap. The results were reproducible in the retest session. Our findings suggest that the interaction between age and gap duration should be considered when applying the gap-induced inhibition of the cortical-evoked potential as an objective measure of tinnitus in human subjects. Further studies with tinnitus patients are warranted to identify gap duration that would minimize the effects of age and maximize the difference in the inhibition between those with and without tinnitus.

Roles of the glutamate receptor ε2 and δ2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex

2001 ◽  
Vol 14 (1) ◽  
pp. 153-160 ◽  
Author(s):  
Tomonori Takeuchi ◽  
Yuji Kiyama ◽  
Kazuhiro Nakamura ◽  
Mika Tsujita ◽  
Ikuo Matsuda ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
Glutamate Receptor ◽  
Acoustic Startle ◽  
Startle Reflex ◽  
Acoustic Startle Reflex

scholarly journals Prepulse Inhibition of the Acoustic Startle Reflex in High Functioning Autism

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92372 ◽  
Author(s):  
Sina Kohl ◽  
Carolin Wolters ◽  
Theo O. J. Gruendler ◽  
Kai Vogeley ◽  
Joachim Klosterkötter ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
High Functioning Autism ◽  
Acoustic Startle ◽  
Startle Reflex ◽  
Acoustic Startle Reflex ◽  
High Functioning

Prepulse inhibition of the acoustic startle reflex in pigs and its disruption by d-amphetamine

2004 ◽  
Vol 155 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Nanna M. Lind ◽  
Sidse M. Arnfred ◽  
Ralf P. Hemmingsen ◽  
Axel K. Hansen
Keyword(s):  
Prepulse Inhibition ◽  
Acoustic Startle ◽  
Startle Reflex ◽  
Acoustic Startle Reflex

scholarly journals  Life-Course Contribution of Prenatal Stress in Regulating the Neural Modulation Network Underlying the Prepulse Inhibition of the Acoustic Startle Reflex in Male Alzheimer’s Disease Mice

2019 ◽  
Vol 30 (1) ◽  
pp. 311-325 ◽  
Author(s):  
Zahra Jafari ◽  
Bryan E Kolb ◽  
Majid H Mohajerani
Keyword(s):  
Prepulse Inhibition ◽  
Hpa Axis ◽  
Prenatal Stress ◽  
Acoustic Startle ◽  
Sensorimotor Gating ◽  
Startle Reflex ◽  
Underlying Mechanism ◽  
Acoustic Startle Reflex ◽  
Abnormal Development ◽  
Brain Areas

Abstract The prepulse inhibition (PPI) of the acoustic startle reflex (ASR), as an index of sensorimotor gating, is one of the most extensively used paradigms in the field of neuropsychiatric disorders. Few studies have examined how prenatal stress (PS) regulates the sensorimotor gating during the lifespan and how PS modifies the development of amyloid-beta (Aβ) pathology in brain areas underlying the PPI formation. We followed alternations in corticosterone levels, learning and memory, and the PPI of the ASR measures in APPNL-G-F/NL-G-F offspring of dams exposed to gestational noise stress. In-depth quantifications of the Aβ plaque accumulation were also performed at 6 months. The results indicated an age-dependent deterioration of sensorimotor gating, long-lasting PS-induced abnormalities in PPI magnitudes, as well as deficits in spatial memory. The PS also resulted in a higher Aβ aggregation predominantly in brain areas associated with the PPI modulation network. The findings suggest the contribution of a PS-induced hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in regulating the PPI modulation substrates leading to the abnormal development of the neural protection system in response to disruptive stimuli. The long-lasting HPA axis dysregulation appears to be the major underlying mechanism in precipitating the Aβ deposition, especially in brain areas contributed to the PPI modulation network.

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