The non-benzodiazepine anxiolytic etifoxine limits mechanical allodynia and anxiety-like symptoms in a mouse model of streptozotocin-induced diabetic neuropathy

More than 450 million people worldwide suffer from diabetes, or 1 in 11 people. Chronic hyperglycemia degrades patients’ quality of life and the development of neuropathic pain contributes to the burden of this disease. In this study, we used the mouse model of streptozocin-induced diabetic type 1 neuropathy to assess the analgesic potential of etifoxine. Etifoxine is a prescribed anxiolytic that increases GABAAA receptor function through a direct positive allosteric modulation effect and, indirectly, by stimulating the production of endogenous GABAA receptor positive modulators such as allopregnanolone-type neurosteroids. We show that a post-symptomatic or preventive treatment strongly and durably reduces mechanical hyperalgesia and anxiety in diabetic neuropathic mice. This analgesic and neuroprotective effect on painful symptoms and emotional comorbidities is promising and should now be clinically evaluated.

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The non-benzodiazepine anxiolytic etifoxine limits the sensory-affective expression of pain following streptozotocin-induced diabetic neuropathy

10.1101/2021.02.22.432248 ◽

2021 ◽

Author(s):

Géraldine Gazzo ◽

Marlene Salgado Ferrer ◽

Pierrick Poisbeau

Keyword(s):

Neuroprotective Effect ◽

Preventive Treatment ◽

Allosteric Modulation ◽

Receptor Function ◽

Modulation Effect ◽

Diabetic Type ◽

Affective Expression ◽

Chronic Hyperglycemia

AbstractMore than 450 million people worldwide suffer from diabetes, or 1 in 11 people. Chronic hyperglycemia degrades patients’ quality of life and the development of neuropathic pain contributes to the burden of this disease. In this study, we used the mouse model of streptozocin-induced diabetic type 1 neuropathy to assess the analgesic potential of etifoxine. Etifoxine is a prescribed anxiolytic that increases GABAAA receptor function through a direct positive allosteric modulation effect and, indirectly, by stimulating the production of endogenous GABAA receptor positive modulators such as allopregnanolone-type neurosteroids. We show that a curative or preventive treatment strongly and durably reduces mechanical hyperalgesia and anxiety in diabetic neuropathic mice. This analgesic and neuroprotective effect on painful symptoms and emotional comorbidities is promising and should now be clinically evaluated.

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TAT-tagging of VIP exerts positive allosteric modulation of the PAC1 receptor and enhances VIP neuroprotective effect in the MPTP mouse model of Parkinson's disease

Biochimica et Biophysica Acta (BBA) - General Subjects ◽

10.1016/j.bbagen.2020.129626 ◽

2020 ◽

Vol 1864 (8) ◽

pp. 129626

Author(s):

Rongjie Yu ◽

Junfeng Li ◽

Zhuochao Lin ◽

Zehua Ouyang ◽

Xiaoling Huang ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Mouse Model ◽

Neuroprotective Effect ◽

Allosteric Modulation ◽

Pac1 Receptor

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Kinematic Analysis of the Musculoskeletal System Diabetic Type I

European Scientific Journal ESJ ◽

10.19044/esj.2018.v14n15p414 ◽

2018 ◽

Vol 14 (15) ◽

pp. 414

Author(s):

Khaled Atiyat ◽

Osama "Abdul Fattah" ◽

Ayed Ali Zureigat

Keyword(s):

Musculoskeletal System ◽

Kinematic Analysis ◽

Natural Extension ◽

Video Camera ◽

Type I ◽

Diabetic Type ◽

Type1 Diabetes ◽

Study Results

This study aimed to apply the principles of biomechanics science correctly, also to be is nested in the treatment of diabetics, and establish kinematic record for musculoskeletal diabetics. In order to improve the quality of life and care for diabetics. To achieve this, the researchers used the kinematic analysis of the musculoskeletal system for (8) mail patients with type1 diabetes, purposive selected and belonging to Jordanian team of Diabetes (age: 21±0.7years, height: 164± 4 cm, mas:58± 0.2 kg, the experience of the disease, 13.3±0.8 years). The study sample was filmed by using video camera (Sony HDR-CX220E) reached speed (50) frame/s. The study results showed that musculoskeletal system for Diabetic Type I differences in their shape of musculoskeletal the rest of the population, consequently people with Type 1 Diabetes have a swayback posture and a lower chest forward posture. and the average of sample study in the flexion spine(77)° and (15)°for extension spine. Where it formed 81% from natural flexion spine and 45% from natural extension spine. The researchers recommend: the necessity informed Diabetic Type I on kinematic analysis of the musculoskeletal system.

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