scholarly journals Usefulness of postoperative surveillance MR for women after breast-conservation therapy: Focusing on MR features of early and late recurrent breast cancer

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252476
Author(s):  
Jeongmin Lee ◽  
Bong Joo Kang ◽  
Sung Hun Kim
Keyword(s):  
Breast Cancer ◽  
Breast Conservation ◽  
Breast Mri ◽  
Breast Conservation Therapy ◽  
Late Recurrence ◽  
Recurrent Breast Cancer ◽  
Early Recurrence ◽  
Dynamic Phase ◽  
Early And Late Recurrence ◽  
Recurrent Breast

Purpose To investigate the imaging characteristics of early and late recurrent breast cancer and the detectability of mammography, ultrasonography, and breast magnetic resonance imaging (MRI) in patients who underwent breast-conservation therapy (BCT). Materials and methods Total of 1312 women with 2026 surveillance breast MRI after BCT between January 2014 and September 2018 were studied. Early recurrence was defined as newly diagnosed breast cancer and/or axillary metastasis within 12 months of surgery. Late recurrence was defined as recurrence after 12months of surgery. We assessed the detectability of recurrent lesions in each postoperative imaging modality and evaluated characteristics of recurrent lesions on postoperative MRI by comparing early and late recurrence groups. Result Of the 2026 cases, 103 were confirmed as recurrent breast cancer by biopsy or surgery. Thirty-one cases were early recurrence, and 72 cases were late recurrence. MRI showed significantly higher detectability for recurrent lesions (102 cases, 99%) than mammography (59.4%, p < 0.001) or ultrasound (68.9%, p < 0.001), or both mammography and ultrasound (81.6%, p < 0.001). The recurrent lesions did not have typical malignant morphologic features, but variable features on MRI. However, early recurrent lesions showed fast enhancement in early dynamic phase regardless of the kinetic pattern of delayed dynamic phase; and late recurrence lesions showed early fast enhancement and delayed washout pattern. There were 19 cases which were not detected on mammography or ultrasound but could only be detected with MRI. Conclusion Postoperative breast MRI showed significantly higher detectability for recurrent lesions than mammography and ultrasound. Early fast enhancement is the most important feature of recurrent lesions on postoperative breast MRI for both early and late recurrence groups. Due to its high possibility of recurrence, further work-up should be considered regardless of their morphologic features.

scholarly journals The Risk Factors Influencing between the Early and Late Recurrence in Systemic Recurrent Breast Cancer

2012 ◽  
Vol 15 (2) ◽  
pp. 218 ◽  
Author(s):  
Won Jong Song ◽  
Kwan Il Kim ◽  
Sang Hyun Park ◽  
Mi Seon Kwon ◽  
Tae Hoon Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Late Recurrence ◽  
Recurrent Breast Cancer ◽  
Factors Influencing ◽  
Early And Late Recurrence ◽  
Recurrent Breast

Mammographic Appearance of Recurrent Breast Cancer after Breast Conservation Therapy

2008 ◽  
Vol 15 (2) ◽  
pp. 240-244 ◽  
Author(s):  
Susan P. Weinstein ◽  
Susan G. Orel ◽  
Niveditha Pinnamaneni ◽  
Julia Tchou ◽  
Brian Czerniecki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Conservation ◽  
Breast Conservation Therapy ◽  
Recurrent Breast Cancer ◽  
Recurrent Breast

scholarly journals MRI surveillance for women with a personal history of breast cancer: comparison between abbreviated and full diagnostic protocol

2020 ◽  
Vol 93 (1106) ◽  
pp. 20190733 ◽  
Author(s):  
Ko Woon Park ◽  
Sol Bee Han ◽  
Boo-Kyung Han ◽  
Eun Sook Ko ◽  
Ji Soo Choi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
Diagnostic Performance ◽  
Area Under The Curve ◽  
Breast Mri ◽  
Recurrent Breast Cancer ◽  
Personal History ◽  
History Of ◽  
Recurrent Breast

Objective: To compare the diagnostic performance of breast MRI with abbreviated protocol (AB-MRI) and full ddiagnostic protocol (FDP-MRI) for surveillance of females with a personal history of breast cancer Methods: In this retrospective study, we analyzed the outcomes of total 1312 post-operative screening breast MRI matched from 1045 AB-MRI and 677 FDP-MRI, which had histologic confirmation for suspicious MRI findings or 1 year negative follow-up images. This study was approved by the institutional review board and informed patient consent was waved. AB-MRI consists of T2 weighted scanning and dynamic contrast-enhanced imaging including one pre-contrast and two post-contrast scans. We compared the diagnostic performance for recurrent breast cancer in terms of sensitivity, specificity, positive-predictive value, negative-predictive value, and accuracy and area under the curve between the screening AB-MRI and FDP-MRI. Results: Overall, 13 recurrent tumors among 1312 post-operative cases screened with breast MRI (1.0%) were detected including 8 invasive cancer, 2 cases of in situ cancer, and 3 cases of metastatic lymph nodes. The sensitivity and negative predictive value were 70 vs 100 and 99.5% vs 100% in AB-MRI and FDP-MRI. Specificity, positive predictive value, accuracy, and area under the curve of AB-MRI and FDP-MRI were 98.0% vs 96.9%, 35.0% vs 23.1%, 97.6% vs 97.0%, and 0.840 vs 0.985, respectively. Conclusion: The performance of AB-MRI was comparable to that of FDP-MRI in detecting recurrent breast cancer and decreased false positive cases. Advances in knowledge: AB-MRI provides a reliable alternative with similar diagnostic performance and shorter MRI acquisition time.

Association of preoperative breast MRI features with locoregional recurrence after breast conservation therapy

2017 ◽  
Vol 59 (4) ◽  
pp. 409-417 ◽  
Author(s):  
Min Sun Bae ◽  
Jung Min Chang ◽  
Nariya Cho ◽  
Wonshik Han ◽  
Han Suk Ryu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Locoregional Recurrence ◽  
Breast Conservation ◽  
Breast Mri ◽  
Breast Conservation Therapy ◽  
Mri Features ◽  
Increased Risk ◽  
Preoperative Breast Mri ◽  
Multifocal Disease ◽  
And Control

Background Locoregional recurrence (LRR) following breast conservation therapy (BCT) is associated with an increased risk of distant metastasis and death in patients with breast cancer. Purpose To investigate whether preoperative breast magnetic resonance imaging (MRI) features are associated with the risk of LRR in patients undergoing BCT. Material and Methods A total of 3781 women with primary invasive breast cancer underwent preoperative MRI and BCT between 2003 and 2013. Forty-eight patients who developed LRR comprised the LRR cohort and one-to-one matching (age, tumor stage, grade, and axillary nodal status) of each patient to a control participant was performed in patients who did not develop recurrence. Three readers independently reviewed MR images of the index cancer and the presence of multifocal disease was assessed. Χ2 analysis was used to compare imaging and clinical features between LRR and control cohorts, with multivariate logistic regression analysis used to identify independent features. Results Significant differences were found in the proportion of multifocal disease ( P = 0.001), background parenchymal enhancement level ( P = 0.007), and breast cancer molecular subtype ( P = 0.01) between LRR and control cohorts. Multivariate analysis showed that multifocal disease (odds ratio [OR] = 11.9; 95% confidence interval [CI] = 1.4–102.5; P = 0.02) and human epidermal growth factor receptor 2-positive subtype (OR = 12.7; 95% CI = 1.3–127.6; P = 0.03) were both independently associated with LRR. Conclusion Multifocal disease on preoperative breast MRI may indicate an increased risk of LRR in patients treated with BCT.

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