scholarly journals The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262257
Author(s):  
Massimiliano Lia ◽  
Lars-Christian Horn ◽  
Paulina Sodeikat ◽  
Michael Höckel ◽  
Bahriye Aktas ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cervical Carcinoma ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Clinical Decision Making ◽  
Tumor Grade ◽  
Diagnostic Value ◽  
Tumor Type ◽  
Histological Subtype ◽  
Core Needle

Cervical carcinoma is a major cause of morbidity and mortality among women worldwide. Histological subtype, lymphovascular space invasion and tumor grade could have a prognostic and predictive value for patients’ outcome and the knowledge of these histologic characteristics may influence clinical decision making. However, studies evaluating the diagnostic value of various biopsy techniques regarding these parameters of cervical cancer are scarce. We reviewed 318 cases of cervical carcinoma with available pathology reports from preoperative core needle biopsy (CNB) assessment and from final postoperative evaluation of the hysterectomy specimen. Setting the postoperative comprehensive pathological evaluation as reference, we analysed CNB assessment of histological tumor characteristics. In addition, we performed multivariable logistic regression to identify factors influencing the accuracy in identifying LVSI and tumor grade. CNB was highly accurate in discriminating histological subtype. Sensitivity and specificity were 98.8% and 89% for squamous cell carcinoma, 92.9% and 96.6% for adenocarcinoma, 33.3% and 100% in adenosquamous carcinoma respectively. Neuroendocrine carcinoma was always recognized correctly. The accuracy of the prediction of LVSI was 61.9% and was positively influenced by tumor size in preoperative magnetic resonance imaging and negatively influenced by strong peritumoral inflammation. High tumor grade (G3) was diagnosed accurately in 73.9% of cases and was influenced by histological tumor type. In conclusion, CNB is an accurate sampling technique for histological classification of cervical cancer and represents a reasonable alternative to other biopsy techniques.

The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e17512-e17512
Author(s):  
Massimiliano Lia ◽  
Lars-Christian Horn ◽  
Paulina Sodeikat ◽  
Michael Höckel ◽  
Bahriye Aktas ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Core Needle Biopsy ◽  
Tumor Size ◽  
Needle Biopsy ◽  
Sampling Technique ◽  
Tumor Grade ◽  
Tumor Type ◽  
Predictive Values ◽  
Core Needle ◽  
Lymphovascular Space Invasion

e17512 Background: The aim of this retrospective study was to evaluate the accuracy, sensitivity, specificity, and predictive values of preoperative core needle biopsy (CNB) assessment of histological characteristics in primary cervical cancer. Methods: We reviewed 318 cases of primary cervical carcinoma with available pathology reports from preoperative CNB assessment and from final postoperative evaluation of the hysterectomy specimen. Setting the postoperative comprehensive pathological evaluation as reference, we analysed CNB assessment of histological tumor characteristics. In addition, we performed multivariable logistic regression to identify factors influencing the accuracy in identifying lymphovascular space invasion (LVSI) and tumor grade. Results: CNB was highly accurate in discriminating histological subtype. Sensitivity and specificity were 98.8% and 89% for squamous cell carcinoma (SCC), 92.9% and 96.6% for adenocarcinoma (AC), 33.3% and 100% in adenosquamous carcinoma respectively. Neuroendocrine carcinoma was always recognized correctly. The accuracy of the prediction of lymphovascular space invasion (LVSI) was 61.9% and was positively influenced by tumor size in preoperative MRI and negatively influenced by strong peritumoral inflammation. High tumor grade was diagnosed accurately in 73.9% of cases and was influenced by histological tumor type. Conclusions: CNB is an accurate sampling technique for histological classification of cervical cancer and represents a reasonable alternative to other biopsy techniques. Factors such as peritumoral inflammation, tumor size or tumor subtype may influence the accuracy of histologic Evaluation and should be taken into account when interpreting the results.

Diagnostic value of core needle biopsy and fine-needle aspiration in salivary gland lesions

Head & Neck ◽  
2015 ◽  
Vol 38 (S1) ◽  
pp. E346-E352 ◽  
Author(s):  
Eva Novoa ◽  
Nicolas Gürtler ◽  
André Arnoux ◽  
Marcel Kraft
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Diagnostic Value ◽  
Needle Aspiration ◽  
Core Needle ◽  
Fine Needle

scholarly journals Diagnostic value and complication rate of ultrasound-guided transthoracic core needle biopsy in mediastinal lesions

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0231523 ◽  
Author(s):  
Rosen Petkov ◽  
Tzvetan Minchev ◽  
Yordanka Yamakova ◽  
Evgeni Mekov ◽  
Georgi Yankov ◽  
...  
Keyword(s):  
Complication Rate ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Diagnostic Value ◽  
Ultrasound Guided ◽  
Core Needle

Diagnostic value of ultrasound guided transthoracic core needle biopsy in mediastinal lesions

2015 ◽  
Author(s):  
Rosen Petkov ◽  
Tzvetan Minchev ◽  
Yordanka Yamakova ◽  
Danail Petrov ◽  
Emilia Petkova
Keyword(s):  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Diagnostic Value ◽  
Ultrasound Guided ◽  
Core Needle

Ultrasonography-Guided Core Needle Biopsy Diagnostic Value in Breast Lump Assessment: An Experience From the Middle East

2020 ◽  
Vol 37 (1) ◽  
pp. 5-11
Author(s):  
Ahmed Hussein Al-Ismaeel ◽  
Ahmed Nugud ◽  
Assmaa Nugud ◽  
Shomous Nugud
Keyword(s):  
Sensitivity And Specificity ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Ductal Carcinoma ◽  
Diagnostic Value ◽  
Management Plan ◽  
Detection Methods ◽  
Predictive Values ◽  
Core Needle ◽  
Tertiary Center

Objective: Breast cancer is a leading cause of mortality in industrialized and developing countries. Mammography and a core needle biopsy are among the detection methods that are used to diagnose and confirm tumor subtypes. Methods: A retrospective, noninterventional observational study was conducted in a tertiary center between January 2009 and December 2014. A total of 265 patients underwent ultrasonography (US)–guided core needle biopsy (CNB). A cohort of 147 patients met the inclusion criteria and data were subsequently extracted from their medical records. Results: From this cohort, US-CNB detected malignant lesions in 109 patients, with a total sensitivity and specificity for malignancy at 96.33% and 75.10%, respectively. The most frequent malignant tumor diagnosed with US-CNB was invasive ductal carcinoma. The most common benign masses detected were 38 (32.1%) fibroadenomas and fat necrosis. The positive and negative predictive values for US-CNB were 92.4% and 87.5%, respectively. Conclusion: The findings would suggest that the use of US-CNB could play a major role in the identification and management of the breast lesions. It could also redeem any biopsy errors or operator inexperience. Sensitivity and specificity in detecting tumors, malignant or benign, using US-CNB could aid in efforts to provide an appropriate medical management plan.

Role of contrast-enhanced ultrasound guidance in core-needle biopsy for diagnosis of cervical tuberculous lymphadenitis

2020 ◽  
pp. 1-9
Author(s):  
Dan Zhao ◽  
Ya-Qin Shao ◽  
Jun Hu ◽  
Dan Liu ◽  
Wei Tang ◽  
...  
Keyword(s):  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Diagnostic Value ◽  
Size Group ◽  
Medium Size ◽  
Tuberculous Lymphadenitis ◽  
Contrast Enhanced Ultrasound ◽  
Diagnostic Efficacy ◽  
Core Needle ◽  
Contrast Enhanced

OBJECTIVE: To investigate the diagnostic value of core-needle biopsy (CNB) guided by contrast-enhanced ultrasound (CEUS) in cervical tuberculous lymphadenitis (CTL). METHODS: 178 patients with pathological confirmation of CTL were retrospectively enrolled. All of them had undergone CNB prior to the final surgery. According to the different ways of puncture guidance, they were divided into two groups: conventional ultrasound (US) group (n = 81) and CEUS group (n = 97). The comparison of diagnostic efficacy between two groups was compared and analyzed. RESULTS: Among the 178 patients, 146 were directly diagnosed as CTL by CNB, including 59 patients in CEUS group and 87 patients in US group. The diagnostic accuracy were 89.7% (87/97) and 72.8% (59/81), respectively (P <  0.01). For subgroup analyses, differences among diagnostic efficacy ascribed to the different guiding methods were significant in medium size group (>2.0 cm and ≤3.0 cm) and large size group (>3.0 cm), 91.7% for CEUS group vs. 69.0% for US group (P <  0.05) and 84.4% for CEUS group vs. 57.7% for US group (P <  0.05), respectively. CONCLUSIONS: In the diagnosis of CTL, compared with the US-guided CNB, CEUS-guided CNB have certain advantages, especially for larger lymph nodes.

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