scholarly journals B Cells Enhance Antigen-Specific CD4 T Cell Priming and Prevent Bacteria Dissemination following Chlamydia muridarum Genital Tract Infection

2013 ◽  
Vol 9 (10) ◽  
pp. e1003707 ◽  
Author(s):  
Lin-Xi Li ◽  
Stephen J. McSorley
Keyword(s):  
T Cell ◽  
B Cells ◽  
Tract Infection ◽  
Genital Tract ◽  
Cd4 T Cell ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum ◽  
T Cell Priming

scholarly journals CD43−, but not CD43+, IL-10-producing CD1dhiCD5+ B cells suppress type 1 immune responses during Chlamydia muridarum genital tract infection

2014 ◽  
Vol 8 (1) ◽  
pp. 94-106 ◽  
Author(s):  
J M Moore-Connors ◽  
H S Kim ◽  
J S Marshall ◽  
A W Stadnyk ◽  
S A Halperin ◽  
...  
Keyword(s):  
B Cells ◽  
Tract Infection ◽  
Immune Responses ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum

scholarly journals In Situ Analysis of the Evolution of the Primary Immune Response in Murine Chlamydia trachomatis Genital Tract Infection

2000 ◽  
Vol 68 (5) ◽  
pp. 2870-2879 ◽  
Author(s):  
Sandra G. Morrison ◽  
Richard P. Morrison
Keyword(s):  
T Cells ◽  
T Cell ◽  
B Cells ◽  
Chlamydia Trachomatis ◽  
Tract Infection ◽  
Inflammatory Response ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Tnf Α

ABSTRACT Adaptive immune responses contribute to the resolution ofChlamydia trachomatis genital tract infection and protect against reinfection, but our understanding of the mechanisms of those protective responses is incomplete. In this study, we analyzed by in situ immunohistochemistry the progression of the inflammatory and cytokine responses in the genital tracts of mice vaginally infected with C. trachomatis strain mouse pneumonitis. The cellular inflammatory response was characterized by an initial elevation in myeloid cells in the vagina (day 3) and uterine horns (day 7), followed by a marked rise in the number of T cells, predominantly CD4+ cells. CD8+ T cells and CD45R+B cells were also detected but were much less numerous. Perivascular clusters of CD4+ T cells, which resembled clusters of T cells seen in delayed-type hypersensitivity responses, were evident by 2 weeks postinfection. Following the resolution of infection, few CD8+ T cells and CD45R+ B cells remained, whereas numerous CD4+ T cells and perivascular clusters of CD4+ T cells persisted in genital tract tissues. Interleukin-12 (IL-12)- and tumor necrosis factor alpha (TNF-α)-producing cells were observed in vaginal tissue by day 3 of infection and in uterine tissues by day 7. Cells producing IL-4 or IL-10 were absent from vaginal tissues at day 3 of infection but were present in uterine tissues by day 7 and were consistently more numerous than IL-12- and TNF-α-producing cells. Thus, the evolution of the local inflammatory response was characterized by the accumulation of CD4+ T cells into perivascular clusters and the presence of cells secreting both Th1- and Th2-type cytokines. The persistence of CD4+-T-cell clusters long after infection had resolved (day 70) may provide for a readily mobilizable T-cell response by which previously infected animals can quickly respond to and control a secondary infectious challenge.

scholarly journals Histopathologic Changes Related to Fibrotic Oviduct Occlusion After Genital Tract Infection of Mice With Chlamydia muridarum

2005 ◽  
Vol 32 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Anita A. Shah ◽  
Justin H. Schripsema ◽  
Mohammad T. Imtiaz ◽  
Ira M. Sigar ◽  
John Kasimos ◽  
...  
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum ◽  
Histopathologic Changes

scholarly journals The Duration of Chlamydia muridarum Genital Tract Infection and Associated Chronic Pathological Changes Are Reduced in IL-17 Knockout Mice but Protection Is Not Increased Further by Immunization

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e76664 ◽  
Author(s):  
Dean W. Andrew ◽  
Melanie Cochrane ◽  
Justin H. Schripsema ◽  
Kyle H. Ramsey ◽  
Samantha J. Dando ◽  
...  
Keyword(s):  
Tract Infection ◽  
Knockout Mice ◽  
Genital Tract ◽  
Pathological Changes ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum

scholarly journals Toll-like receptor 3 (TLR3) promotes the resolution of Chlamydia muridarum genital tract infection in congenic C57BL/6N mice

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195165 ◽  
Author(s):  
Sebastian E. Carrasco ◽  
Sishun Hu ◽  
Denise M. Imai ◽  
Ramesh Kumar ◽  
George E. Sandusky ◽  
...  
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Toll Like Receptor ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum

scholarly journals B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection

2019 ◽  
Vol 217 (2) ◽  
Author(s):  
E. Nicole Arroyo ◽  
Marion Pepper
Keyword(s):  
T Cell ◽  
B Cells ◽  
Parasite Clearance ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Plasmodium Infection ◽  
B Cell Differentiation ◽  
Tfh Cells ◽  
Acute Response ◽  
T Cell Priming

CD4+ T follicular helper (Tfh) cells dominate the acute response to a blood-stage Plasmodium infection and provide signals to direct B cell differentiation and protective antibody expression. We studied antigen-specific CD4+ Tfh cells responding to Plasmodium infection in order to understand the generation and maintenance of the Tfh response. We discovered that a dominant, phenotypically stable, CXCR5+ Tfh population emerges within the first 4 d of infection and results in a CXCR5+ CCR7+ Tfh/central memory T cell response that persists well after parasite clearance. We also found that CD4+ T cell priming by B cells was both necessary and sufficient to generate this Tfh-dominant response, whereas priming by conventional dendritic cells was dispensable. This study provides important insights into the development of CD4+ Tfh cells during Plasmodium infection and highlights the heterogeneity of antigen-presenting cells involved in CD4+ T cell priming.

The role of an enzymatically inactive CPAF mutant vaccination in Chlamydia muridarum genital tract infection

2021 ◽  
pp. 105137
Author(s):  
Hui Chen ◽  
Bo Peng ◽  
Chunfen Yang ◽  
Lijuan Xie ◽  
Shufang Zhong ◽  
...  
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum

Male Rat Genital Tract Infection With Chlamydia Muridarum has No Significant Consequence on Male Fertility

2012 ◽  
Vol 187 (5) ◽  
pp. 1911-1917 ◽  
Author(s):  
Ruben Darío Motrich ◽  
Leonardo Sanchez ◽  
Mariana Maccioni ◽  
Juan Pablo Mackern-Oberti ◽  
Virginia Elena Rivero
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Male Fertility ◽  
Male Rat ◽  
Genital Tract Infection ◽  
Chlamydia Muridarum

scholarly journals Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 cell restimulation

1999 ◽  
Vol 29 (9) ◽  
pp. 2705-2714 ◽  
Author(s):  
Francesca Aloisi ◽  
Francesco Ria ◽  
Sandra Columba-Cabezas ◽  
Henry Hess ◽  
Giuseppe Penna ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
B Cells ◽  
Relative Efficiency ◽  
Cd4 T Cell ◽  
Th2 Cell ◽  
T Cell Priming
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