scholarly journals Fcγ-receptor IIa-mediated Src Signaling Pathway Is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection

2016 ◽  
Vol 12 (12) ◽  
pp. e1006139 ◽  
Author(s):  
Wakako Furuyama ◽  
Andrea Marzi ◽  
Aaron B. Carmody ◽  
Junki Maruyama ◽  
Makoto Kuroda ◽  
...  
Keyword(s):  
Virus Infection ◽  
Signaling Pathway ◽  
Ebola Virus ◽  
Fcγ Receptor ◽  
Antibody Dependent Enhancement ◽  
Src Signaling ◽  
Ebola Virus Infection

scholarly journals Antibody-Dependent Enhancement of Ebola Virus Infection

2003 ◽  
Vol 77 (13) ◽  
pp. 7539-7544 ◽  
Author(s):  
Ayato Takada ◽  
Heinz Feldmann ◽  
Thomas G. Ksiazek ◽  
Yoshihiro Kawaoka
Keyword(s):  
Virus Infection ◽  
Ebola Virus ◽  
Human Populations ◽  
Hemorrhagic Disease ◽  
Viral Infectivity ◽  
Kidney Cells ◽  
Emerging Pathogens ◽  
Viral Glycoprotein ◽  
Antibody Dependent Enhancement ◽  
Ebola Virus Infection

ABSTRACT Most strains of Ebola virus cause a rapidly fatal hemorrhagic disease in humans, yet there are still no biologic explanations that adequately account for the extreme virulence of these emerging pathogens. Here we show that Ebola Zaire virus infection in humans induces antibodies that enhance viral infectivity. Plasma or serum from convalescing patients enhanced the infection of primate kidney cells by the Zaire virus, and this enhancement was mediated by antibodies to the viral glycoprotein and by complement component C1q. Our results suggest a novel mechanism of antibody-dependent enhancement of Ebola virus infection, one that would account for the dire outcome of Ebola outbreaks in human populations.

scholarly journals A complement component C1q-mediated mechanism of antibody-dependent enhancement of Ebola virus infection

2020 ◽  
Vol 14 (9) ◽  
pp. e0008602 ◽  
Author(s):  
Wakako Furuyama ◽  
Asuka Nanbo ◽  
Junki Maruyama ◽  
Andrea Marzi ◽  
Ayato Takada
Keyword(s):  
Virus Infection ◽  
Ebola Virus ◽  
Complement Component ◽  
Antibody Dependent Enhancement ◽  
Ebola Virus Infection

scholarly journals Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors

Cell Reports ◽  
2018 ◽  
Vol 24 (7) ◽  
pp. 1802-1815.e5 ◽  
Author(s):  
Natalia A. Kuzmina ◽  
Patrick Younan ◽  
Pavlo Gilchuk ◽  
Rodrigo I. Santos ◽  
Andrew I. Flyak ◽  
...  
Keyword(s):  
Virus Infection ◽  
Ebola Virus ◽  
Antibody Dependent Enhancement ◽  
Human Antibodies ◽  
Ebola Virus Infection

Epitopes Required for Antibody‐Dependent Enhancement of Ebola Virus Infection

2007 ◽  
Vol 196 (s2) ◽  
pp. S347-S356 ◽  
Author(s):  
Ayato Takada ◽  
Hideki Ebihara ◽  
Heinz Feldmann ◽  
Thomas W. Geisbert ◽  
Yoshihiro Kawaoka
Keyword(s):  
Virus Infection ◽  
Ebola Virus ◽  
Antibody Dependent Enhancement ◽  
Ebola Virus Infection

P.131 Peripartum management of a patient with previous Ebola virus infection

2021 ◽  
Vol 46 ◽  
pp. 103129
Author(s):  
V. Thwaites ◽  
T. Murphy ◽  
E.C. Thomson
Keyword(s):  
Virus Infection ◽  
Ebola Virus ◽  
Ebola Virus Infection

scholarly journals Loss of Interleukin 1 Receptor Antagonist Enhances Susceptibility to Ebola Virus Infection

2015 ◽  
Vol 212 (suppl 2) ◽  
pp. S329-S335 ◽  
Author(s):  
Lindsay Hill-Batorski ◽  
Peter Halfmann ◽  
Andrea Marzi ◽  
Tiago J. S. Lopes ◽  
Gabriele Neumann ◽  
...  
Keyword(s):  
Virus Infection ◽  
Receptor Antagonist ◽  
Ebola Virus ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Ebola Virus Infection
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