The Effect of Aminophylline on Cerebral Blood Flow in Patients with Chronic Obstructive Pulmonary Disease

CHEST Journal ◽  
1987 ◽  
Vol 91 (6) ◽  
pp. 874-877 ◽  
Author(s):  
David L. Bowton ◽  
Peter T. Alford ◽  
Byron D. McLees ◽  
Donald S. Prough ◽  
David A. Stump
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Comparison of cerebral blood flow in subjects with and without chronic obstructive pulmonary disease from the population-based Rotterdam Study

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e053671
Author(s):  
Sara R A Wijnant ◽  
Daniel Bos ◽  
Guy Brusselle ◽  
Maxim Grymonprez ◽  
Ernst Rietzschel ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pulmonary Disease ◽  
Population Based ◽  
Chronic Obstructive ◽  
Rotterdam Study ◽  
Obstructive Pulmonary Disease ◽  
Cardiovascular Comorbidities ◽  
Cerebral Mri

ObjectivesPatients with chronic obstructive pulmonary disease (COPD) are at increased risk of cerebrovascular disease, which might be associated with decreases in cerebral blood flow. Since studies examining cerebral blood flow in COPD remain scarce and are limited by sample size, we aimed to study cerebral blood flow in participants with and without COPD.DesignObservational cohort study.SettingPopulation-based Rotterdam Study.Participants4177 participants (age 68.0±8.5 years; 53% females) with and without COPD.Predictor variableSpirometry and pulmonary diffusing capacity.Outcome measuresCerebral blood flow by two-dimensional phase-contrast cerebral MRI.ResultsCompared with subjects with normal spirometry (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ≥0.7 and FEV1 ≥80%), multivariable adjusted cerebral blood flow (mL/min) was preserved in subjects with COPD Global initiative for Chronic Obstructive Lung Disease (GOLD1) (FEV1/FVC <0.7 and FEV1 ≥80%), but significantly lower in subjects with COPD GOLD2-3 (FEV1/FVC <0.7 and FEV1 <80%), even after adjustment for cardiovascular comorbidities. In sex-stratified analyses, this difference in cerebral blood flow was statistically significant in women but not in men. Cerebral blood flow was lowest in subjects with FEV1, FVC and diffusion lung capacity for carbon monoxide % predicted values in the lowest quintile, even after adjustment for cardiovascular comorbidities and cardiac function.ConclusionWe observed a lowered cerebral blood flow in subjects with COPD GOLD2-3.

scholarly journals Effect of L-arginine on renal blood flow in normal subjects and patients with hypoxic chronic obstructive pulmonary disease.

Thorax ◽  
1996 ◽  
Vol 51 (5) ◽  
pp. 516-519 ◽  
Author(s):  
T. Q. Howes ◽  
S. E. Keilty ◽  
V. L. Maskrey ◽  
C. R. Deane ◽  
S. V. Baudouin ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Blood Flow ◽  
Renal Blood Flow ◽  
Pulmonary Disease ◽  
Normal Subjects ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Preserved muscle metaboreflex in chronic obstructive pulmonary disease

2011 ◽  
Vol 36 (6) ◽  
pp. 821-830 ◽  
Author(s):  
Megan F.B. Sherman ◽  
Jeremy D. Road ◽  
Donald C. McKenzie ◽  
A. William Sheel
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Heart Rate ◽  
Blood Flow ◽  
Pulmonary Disease ◽  
Exercise Capacity ◽  
Chronic Obstructive ◽  
Healthy Controls ◽  
Obstructive Pulmonary Disease ◽  
Muscle Metaboreflex ◽  
Severe Copd

The objective of this study was to measure the magnitude of the muscle metaboreflex in people with chronic obstructive pulmonary disease (COPD) compared with healthy controls and to assess the relationships between disease severity, exercise capacity, and the magnitude of the muscle metaboreflex. Nine people with mild-to-severe COPD and 11 age- and gender-matched healthy controls performed isometric handgrip exercise (IHG), followed by postexercise circulatory occlusion (PECO) while hemodynamic changes were measured. Continuous measures of heart rate, arterial pressure, leg blood flow, leg vascular resistance, and total peripheral resistance were obtained. Participants then performed a cycle test to exhaustion. Heart rate, blood pressure, and blood flow responses during IHG and PECO were similar between the COPD group and healthy controls (p > 0.05). There was no association between disease severity or exercise capacity and the magnitude of the muscle metaboreflex. We observed a preserved muscle metaboreflex in mild-to-severe COPD, suggesting the metaboreflex is not a contributing factor to the development of exercise intolerance in this population.

Pulmonary Function after Emergence on 100% Oxygen in Patients with Chronic Obstructive Pulmonary Disease

2014 ◽  
Vol 120 (5) ◽  
pp. 1146-1151 ◽  
Author(s):  
Axel T. Kleinsasser ◽  
Iris Pircher ◽  
Suzan Truebsbach ◽  
Hans Knotzer ◽  
Alexander Loeckinger ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Blood Flow ◽  
Partial Pressure ◽  
Pulmonary Disease ◽  
Pulmonary Blood Flow ◽  
Chronic Obstructive ◽  
Blood Gas ◽  
Obstructive Pulmonary Disease ◽  
Arterial Partial Pressure ◽  
Oxygen Breathing

Abstract Background: During emergence from anesthesia, breathing 100% oxygen is frequently used to provide a safety margin toward hypoxemia in case an airway problem occurs. Oxygen breathing has been shown to cause pulmonary gas exchange disorders in healthy individuals. This study investigates how oxygen breathing during emergence affects lung function specifically whether oxygen breathing causes added hypoxemia in patients with chronic obstructive pulmonary disease. Methods: This trial has been conducted in a parallel-arm, case-controlled, open-label manner. Fifty-three patients with chronic obstructive pulmonary disease were randomly allocated (computer-generated lists) to breathe either 100 or 30% oxygen balanced with nitrogen during emergence from anesthesia. Arterial blood gas measurements were taken before induction and at 5, 15, and 60 min after extubation. Results: All participants tolerated the study well. Patients treated with 100% oxygen had a higher alveolar–arterial oxygen pressure gradient (primary outcome) compared with patients treated with 30% oxygen (25 vs. 20 mmHg) and compared with their baseline at the 60-min measurement (25 vs. 17 mmHg). At the 60-min measurement, arterial partial pressure of oxygen was lower in the 100% group (62 vs. 67 mmHg). Arterial partial pressure of carbon dioxide and pH were not different between groups or measurements. Conclusions: In this experiment, the authors examined oxygen breathing during emergence—a widely practiced maneuver known to generate pulmonary blood flow heterogeneity. In the observed cohort of patients already presenting with pulmonary blood flow disturbances, emergence on oxygen resulted in deterioration of oxygen-related blood gas parameters. In the perioperative care of patients with chronic obstructive pulmonary disease, oxygen breathing during emergence from anesthesia may need reconsideration.

scholarly journals CARDIORENAL INTERRELATIONSHIPS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2018 ◽  
Vol 1 (68) ◽  
pp. 29-33
Author(s):  
Ираида Меньшикова ◽  
Iraida Men'shikova ◽  
Юлия Квасникова ◽  
Yuliya Kvasnikova ◽  
Елена Магаляс ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Blood Flow ◽  
Left Ventricle ◽  
Right Ventricle ◽  
Renal Blood Flow ◽  
Pulmonary Disease ◽  
The State ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Vessel Resistance

The aim is to study the interrelationships between the state of pulmonary, intracardiac hemodynamics and renal blood flow in patients with chronic obstructive pulmonary disease (COPD) complicated with the chronic cor pulmonale (CCP). 75 patients with COPD complicated with compensated CCP who had the study of pulmonary, intracardiac and renal hemodynamics with the method of ultrasound duplex scanning were examined. The patients were divided into 2 groups: the 1st group included 45 patients with COPD with pulmonary hypertension (PH) without clinical signs of right ventricle insufficiency; the 2nd group included 30 patients with COPD and PH complicated with right ventricle insufficiency. It was found out that the patients with COPD alongside with the progression of the disease and development of the heart insufficiency had an increase of renal vessel resistance (p<0.01) and a decrease of the velocity of renal blood flow (p<0.001). In the first group of patients there was found a consistent correlation between the increase of the vessel resistance in renal arteries and growth of general peripheral vessel resistance (p<0.001), of systolic pressure in the pulmonary artery (p<0.001) and diastolic dysfunction of the left ventricle (LV) (p<0.001), suggested the influence of these predictors on the velocity of the arterial blood flow in kidneys. In the 2nd group there was registered a strong correlation between the decrease of ejection fraction (EF) of LV and the increase of pulsation and resistive indices of arcuate arteries (r=0.69; p<0.01 and r=0.71; p<0.01, respectively), as well as the increase of end-diastolic volume, end-systolic volume of LV and speed parameters of the renal blood flow at all levels (r=0.67; p<0.01). The study of the relationship between the parameters of hemodynamics of the right ventricle (RV) and the state of the renal blood flow revealed a consistent correlation between the decrease of EF of RV and the decrease of diastolic rate at all levels of renal arteries (p<0.001), the increase of resistive (p<0.01) and pulsation indices (p<0.01) of the arterial system of kidneys. These correlations reflect a negative influence of both a left ventricle and right ventricle insufficiency on the state of the renal blood flow.

scholarly journals Features of cerebral blood flow in patients with chronic obstructive pulmonary disease associated with hypertension

2021 ◽  
Vol 26 (6) ◽  
pp. 676-687
Author(s):  
N. B. Poletaeva ◽  
O. V. Teplyakova ◽  
I. F. Grishina ◽  
A. A. Klepikova
Keyword(s):  
Blood Pressure ◽  
Chronic Obstructive Pulmonary Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carotid Artery ◽  
Blood Flow Velocity ◽  
Flow Index ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Blood Flow Index

Objective. The aim of the work was to study the features of cerebral blood flow in patients with chronic obstructive pulmonary disease (COPD) associated with hypertension (HTN). Design and methods. A crosssectional study was conducted, which included 90 males 40–60 years old. Of these, 30 patients with chronic COPD associated with HTN (COPD + HTN) were included in the study group, 30 individuals with isolated COPD were in the comparison group, 30 healthy volunteers were included in the control group. All participants underwent physical examination, spirography, 24-hour blood pressure monitoring and ultrasound examination of cerebral vessels. Results. Patients with COPD + HTN in comparison with the control showed an increase in the diameter (p = 0,018) and complex of the intima-media of the common carotid artery (p = 0,003) while the velocities, resistance index (RI) and pulsation index (PI) did not change. In the basin of the internal carotid artery an increase in RI values was noted (p = 0,018). At the intracranial level there was a decrease in the end-diastolic velocity (p = 0,03) and the time-averaged average blood flow velocity (TAV) (p = 0,033) without due changes RI and PI. At the same time no changes in speed indicators and indices were noted in the vertebral artery basin. Among the indicators of cerebral perfusion in patients with COPD + HTN, hydrodynamic resistance (p = 0,0015), intracranial pressure (ICP) (p = 0,0048) significantly increased, and the cerebral blood flow index was comparable with the control. Assessment of venous cerebral blood flow showed an increase in the diameter of the internal jugular vein (p = 0,021) with unchanged TAV together with an increase in ICP indicating the formation of venous dysfunction. It was shown that the body mass index, forced expiratory volume at the first second, systolic and diastolic blood pressure together determine the peak systolic blood flow velocity from the midbrain artery. Conclusions. The cerebral blood flow in patients with COPD + HTN is characterized by a change in arterial blood flow at the level of both intra- and extracranial vessels, while maintaining a normal cerebral blood flow index, as well as the formation of arteriovenous dyshemia against the background of remodeling of the cerebral vascular bed.

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