scholarly journals Synthesis and Performance of Ferrocene-Bonded Chiral Stationary Phase for RP-HPLC

2014 ◽  
Vol 26 (14) ◽  
pp. 4465-4468 ◽  
Author(s):  
Hui-Jing Li ◽  
Zhi-Fang Song ◽  
Junqiang Yu ◽  
Yang Li ◽  
Ling Feng ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Rp Hplc ◽  
And Performance

scholarly journals Chromatographic and spectroscopic studies on β-cyclodextrin functionalized ionic liquid as chiral stationary phase: Enantioseparation of NSAIDs

2017 ◽  
Vol 36 (1-2) ◽  
pp. 130-148 ◽  
Author(s):  
Nurul Yani Rahim ◽  
Kheng Soo Tay ◽  
Sharifah Mohamad
Keyword(s):  
Ionic Liquid ◽  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Stationary Phases ◽  
Spectroscopic Studies ◽  
Inclusion Complex Formation ◽  
H Nmr ◽  
Inflammatory Drugs ◽  
And Performance ◽  
Multiple Interactions

Recently, we reported a new chiral stationary phase prepared using β-cyclodextrin functionalized with aromatic ionic liquid which is aimed to enhance the performance of enantioseparation of flavonoids and β-blockers. In this paper, the characteristics and performance of previously prepared chiral stationary phase denoted as β-CD-BIMOTs were compared with the newly synthesized chiral stationary phase denoted as β-CD-DIMOTs. β-CD-DIMOTs were prepared by functionalization of β-cyclodextrin with aliphatic ionic liquid. The obtained β-CD-BIMOTs and β-CD-DIMOTs stationary phases were compared with native β-CD stationary phase for the enantioseparation of non-steroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, indoprofen, ketoprofen and fenoprofen). The β-CD-BIMOTs stationary phase showed greater chiral resolution capabilities rather than β-CD-DIMOTs and native β-CD stationary phases. Further, in order to understand the interaction of enantioseparation, the inclusion complex formation between NSAIDs and β-CD-BIMOTs was studied using 1H NMR, NOESY and UV/Vis. The enantioseparated NSAIDs were found to form multiple interactions with β-CD-BIMOTs-CSP.

Evaluation and Comparison of a 3,5-Dimethylphenyl Isocyanate Teicoplanin with Phenyl Isocyanate Teicoplanin Chiral Stationary Phase Using RP-HPLC

2012 ◽  
Vol 30 (1) ◽  
pp. 157-162 ◽  
Author(s):  
Baochun Shen ◽  
Datong Zhang ◽  
Xiaoyan Yu ◽  
Wei Guo ◽  
Yaqiong Han ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Phenyl Isocyanate ◽  
Rp Hplc

Separation of 2-arylpropionic acids on a cellulose based chiral stationary phase by RP-HPLC

1994 ◽  
Vol 12 (7) ◽  
pp. 901-909 ◽  
Author(s):  
A. Van Overbeke ◽  
W. Baeyens ◽  
W. Van Den Bossche ◽  
C. Dewaele
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Rp Hplc

Chiral drugs separation by a new antibiotics-based chiral stationary phase

2014 ◽  
Author(s):  
Chunye Liu ◽  
Yanqing Miao ◽  
Yihui Guo ◽  
Yinjuan An ◽  
Yunfang Li ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Chiral Drugs ◽  
New Antibiotics

Advances in polymer materials as chiral stationary phase

2016 ◽  
Vol 34 (1) ◽  
pp. 34 ◽  
Author(s):  
Rongji DAI ◽  
Huiting WANG ◽  
Weiwei SUN ◽  
Yulin DENG ◽  
Fang LV ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Polymer Materials

scholarly journals Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3527
Author(s):  
Ali Fouad ◽  
Adel A. Marzouk ◽  
Montaser Sh. A. Shaykoon ◽  
Samy M. Ibrahim ◽  
Sobhy M. El-Adl ◽  
...  
Keyword(s):  
Glycidyl Methacrylate ◽  
Chiral Stationary Phase ◽  
Reversed Phase ◽  
Chiral Selector ◽  
Antifungal Drugs ◽  
Organic Polymer ◽  
Rp Hplc ◽  
Macrocyclic Antibiotic ◽  
Adrenergic Blockers ◽  
H1 Blockers

Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC.

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