scholarly journals A Rapid Phase Transfer Catalyzed Heteroarylation by C-O Coupling and Ring Opening of Isopropylidene Glycerol in Synthesis of (Pyrazolopyrimidin-4-yloxy)propane-1,2-diols

2018 ◽  
Vol 30 (10) ◽  
pp. 2352-2356
Author(s):  
Vivek C. Ramani ◽  
Nirmal M. Shah ◽  
Rina D. Shah
Keyword(s):  
Ring Opening ◽  
Phase Transfer ◽  
Rapid Phase ◽  
Isopropylidene Glycerol

Phase Transfer Reagent Promoted Tandem Ring-Opening and Ring-Closing Reactions of Unique 3-(1-Alkynyl) Chromones

2015 ◽  
Vol 17 (9) ◽  
pp. 2134-2137 ◽  
Author(s):  
Yang Liu ◽  
Shiyu Jin ◽  
Liping Huang ◽  
Youhong Hu
Keyword(s):  
Ring Opening ◽  
Phase Transfer

scholarly journals Multiphase extraction: Rapid phase-transfer of [18F]fluoride ion for nucleophilic radiolabeling reactions

1988 ◽  
Vol 39 (11) ◽  
pp. 1109-1111 ◽  
Author(s):  
Douglas M. Jewett ◽  
Steven A. Toorongian ◽  
G.Keith Mulholland ◽  
G.Leonard Watkins ◽  
Michael R. Kilbourn
Keyword(s):  
Phase Transfer ◽  
Fluoride Ion ◽  
Rapid Phase ◽  
18F Fluoride ◽  
Multiphase Extraction

scholarly journals Epoxide Syntheses and Ring-Opening Reactions in Drug Development

Catalysts ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1117
Author(s):  
Fotini Moschona ◽  
Ioanna Savvopoulou ◽  
Maria Tsitopoulou ◽  
Despoina Tataraki ◽  
Gerasimos Rassias
Keyword(s):  
Ring Opening ◽  
Large Scale ◽  
Phase Transfer ◽  
Hiv Protease ◽  
Main Stream ◽  
Hiv Protease Inhibitors ◽  
Chiral Phase ◽  
Diverse Range ◽  
Ring Opening Reactions ◽  
Catalytic Asymmetric

This review concentrates on success stories from the synthesis of approved medicines and drug candidates using epoxide chemistry in the development of robust and efficient syntheses at large scale. The focus is on those parts of each synthesis related to the substrate-controlled/diastereoselective and catalytic asymmetric synthesis of epoxide intermediates and their subsequent ring-opening reactions with various nucleophiles. These are described in the form of case studies of high profile pharmaceuticals spanning a diverse range of indications and molecular scaffolds such as heterocycles, terpenes, steroids, peptidomimetics, alkaloids and main stream small molecules. Representative examples include, but are not limited to the antihypertensive diltiazem, the antidepressant reboxetine, the HIV protease inhibitors atazanavir and indinavir, efinaconazole and related triazole antifungals, tasimelteon for sleep disorders, the anticancer agent carfilzomib, the anticoagulant rivaroxaban the antibiotic linezolid and the antiviral oseltamivir. Emphasis is given on aspects of catalytic asymmetric epoxidation employing metals with chiral ligands particularly with the Sharpless and Jacobsen–Katsuki methods as well as organocatalysts such as the chiral ketones of Shi and Yang, Pages’s chiral iminium salts and typical chiral phase transfer agents.

Regio- and stereoselective ring opening of epoxides with sodium phenylselenide under phase transfer conditions

2008 ◽  
Vol 2008 (1) ◽  
pp. 22-25 ◽  
Author(s):  
Reginaldo Bezerra dos Santos ◽  
Valdemar Lacerda Junior ◽  
Paulo Roberto Zanotto ◽  
Timothy John Brocksom ◽  
Ursula Brocksom
Keyword(s):  
Ring Opening ◽  
Phase Transfer ◽  
Ring Opening Of Epoxides

A rapid phase transfer method for nanoparticles using alkylamine stabilizers

2010 ◽  
Vol 348 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Xinnan Wang ◽  
Shuping Xu ◽  
Ji Zhou ◽  
Weiqing Xu
Keyword(s):  
Phase Transfer ◽  
Rapid Phase ◽  
Transfer Method

Numerical Study on Boiling Mechanism and Rapid Phase Transfer Phenomenon of LNG Discharging on Water

2012 ◽  
Vol 516-517 ◽  
pp. 97-106 ◽  
Author(s):  
Bin Zhang ◽  
Wan Qing Wu ◽  
Jian Wei Zhang
Keyword(s):  
Mass Transfer ◽  
Transfer Rate ◽  
Water Surface ◽  
Phase Transfer ◽  
Numerical Study ◽  
Mass Transfer Rate ◽  
Initial Time ◽  
Rapid Phase ◽  
Boiling Mechanism ◽  
Superheat Limit

Abstract. Aiming at analyzing boiling mechanism and confirming rapid phase Abstract. Aiming at analyzing boiling mechanism and confirming rapid phase transfer (RPT) taking place conditions of LNG discharging on water. The models of pool spreading, heat and mass transfer rate and LNG’s property are coupled in this paper. The conditions of RPT has been confirmed, which included LNG directly contacting with water and the water temperature should higher than LNG’s superheat limit temperature, but the RPT would not take place if the LNG boils on ice. The model of LNG discharging on water has been established in this paper, which is used to simulate Boe and Burro-9 experiments. The results showed that the models can simulate evaporation and boiling rate well, and can be used in predicting the initial time of RPT happening when the discharging process is calm and the location of discharging is near the water surface.

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