in silico Approach Towards Antiinflammation and Anticancer Studies on Phytoconstituents Derived from Cissus quadrangularis

Ethanobotanical and traditional uses of plant Cissus quadrangularis has initiated the phytochemical investigation of the plant. The stem of the plant was subjected for successive solvent extraction with petroleum ether, ethyl acetate, chloroform and ethanol. The crude extract were column choromatographed. Among 20 constituents isolated ascorbic acid, quercetin, phytol and luteol were identified. Later those phytochemicals were subjected for molecular docking in Autodock 4.2 to examine their pharmacological activity. The results obtained showed that these compounds can be further carry over for in vivo analysis.

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Recent advances on in vivo analysis of ascorbic acid in brain functions

TrAC Trends in Analytical Chemistry ◽

10.1016/j.trac.2018.10.017 ◽

2018 ◽

Vol 109 ◽

pp. 247-259 ◽

Cited By ~ 13

Author(s):

Hanjun Cheng ◽

Lijuan Li ◽

Meining Zhang ◽

Ying Jiang ◽

Ping Yu ◽

...

Keyword(s):

Ascorbic Acid ◽

Brain Functions ◽

Recent Advances ◽

In Vivo Analysis

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Bionanosensor based on N-doped graphene quantum dots coupled with CoOOH nanosheets and their application for in vivo analysis of ascorbic acid

Analytica Chimica Acta ◽

10.1016/j.aca.2019.11.008 ◽

2020 ◽

Vol 1100 ◽

pp. 191-199 ◽

Cited By ~ 1

Author(s):

Chunxia Wang ◽

Caiwen Pan ◽

Zitong Wei ◽

Xiaoran Wei ◽

Fan Yang ◽

...

Keyword(s):

Quantum Dots ◽

Ascorbic Acid ◽

Graphene Quantum Dots ◽

Doped Graphene ◽

In Vivo Analysis

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Meiotic CENP-C is a shepherd: bridging the space between the centromere and the kinetochore in time and space

Essays in Biochemistry ◽

10.1042/ebc20190080 ◽

2020 ◽

Vol 64 (2) ◽

pp. 251-261

Author(s):

Jessica E. Fellmeth ◽

Kim S. McKim

Keyword(s):

Chromosome Segregation ◽

New Technologies ◽

Early Prophase ◽

Unique Role ◽

Kinetochore Assembly ◽

M Phase ◽

In Vivo Analysis ◽

Meiosis I

Abstract While many of the proteins involved in the mitotic centromere and kinetochore are conserved in meiosis, they often gain a novel function due to the unique needs of homolog segregation during meiosis I (MI). CENP-C is a critical component of the centromere for kinetochore assembly in mitosis. Recent work, however, has highlighted the unique features of meiotic CENP-C. Centromere establishment and stability require CENP-C loading at the centromere for CENP-A function. Pre-meiotic loading of proteins necessary for homolog recombination as well as cohesion also rely on CENP-C, as do the main scaffolding components of the kinetochore. Much of this work relies on new technologies that enable in vivo analysis of meiosis like never before. Here, we strive to highlight the unique role of this highly conserved centromere protein that loads on to centromeres prior to M-phase onset, but continues to perform critical functions through chromosome segregation. CENP-C is not merely a structural link between the centromere and the kinetochore, but also a functional one joining the processes of early prophase homolog synapsis to late metaphase kinetochore assembly and signaling.

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